Int Arch Occup Environ Health DOI 10.1007/s00420-014-0955-4
Original Article
1‑Hydroxypyrene and oxidative stress marker levels among painting workers and office workers at shipyard Younglim Kho · Eun‑Hee Lee · Hong Jae Chae · Kyungho Choi · Domyung Paek · Sangshin Park
Received: 20 February 2014 / Accepted: 22 June 2014 © Springer-Verlag Berlin Heidelberg 2014
Abstract Objectives The objective of this study was to assess the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and oxidative stress among shipyard workers. Methods We recruited 82 painting workers in a shipyard and age/sex matched 137 office workers from the same shipyard company. Urine samples were used to assess for 1-hydroxypyrene (1-OHP) as an exposure biomarker for PAHs and to assess for 8-iso-prostaglandin F2α (iPF) as a Y. Kho Department of Health, Environment and Safety, Eulji University, Seongnam 461‑713, Gyeonggi, Republic of Korea E.-H. Lee Department of Visual Optics and Health Science, Graduate School of Health Science, Far East University, Eumsung 369‑700, Chungbuk, Republic of Korea H. J. Chae Department of Occupational and Environmental Medicine, KS Hospital, 220 Wangbeodeul, Gwangsan, Gwangju 506‑304, Republic of Korea K. Choi · D. Paek Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul 151‑742, Republic of Korea S. Park Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA S. Park (*) Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA e-mail: [email protected]
biomarker for oxidative stress. Demographics, smoking, alcohol consumption, and working conditions information were obtained from a questionnaire survey. Results Geometric mean concentration (±standard deviation) of urinary 1-OHP among painting workers (587.9 ± 3.45 ng/g creatinine) was approximately 6.9 times higher than that among office workers (85.6 ± 2.09 ng/g creatinine; P value 0.20 was used for removal. Pearson’s correlation analyses were conducted to estimate the correlation between 1-OHP and iPF, with and without adjustments for age, smoking status, and alcohol consumption or not. Urinary 1-OHP and iPF levels were natural log-transformed for multiple linear regression and Pearson’s correlation analyses, because they were highly skewed with a long righthand tail. A P value
Original Article
1‑Hydroxypyrene and oxidative stress marker levels among painting workers and office workers at shipyard Younglim Kho · Eun‑Hee Lee · Hong Jae Chae · Kyungho Choi · Domyung Paek · Sangshin Park
Received: 20 February 2014 / Accepted: 22 June 2014 © Springer-Verlag Berlin Heidelberg 2014
Abstract Objectives The objective of this study was to assess the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and oxidative stress among shipyard workers. Methods We recruited 82 painting workers in a shipyard and age/sex matched 137 office workers from the same shipyard company. Urine samples were used to assess for 1-hydroxypyrene (1-OHP) as an exposure biomarker for PAHs and to assess for 8-iso-prostaglandin F2α (iPF) as a Y. Kho Department of Health, Environment and Safety, Eulji University, Seongnam 461‑713, Gyeonggi, Republic of Korea E.-H. Lee Department of Visual Optics and Health Science, Graduate School of Health Science, Far East University, Eumsung 369‑700, Chungbuk, Republic of Korea H. J. Chae Department of Occupational and Environmental Medicine, KS Hospital, 220 Wangbeodeul, Gwangsan, Gwangju 506‑304, Republic of Korea K. Choi · D. Paek Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul 151‑742, Republic of Korea S. Park Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA S. Park (*) Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA e-mail: [email protected]
biomarker for oxidative stress. Demographics, smoking, alcohol consumption, and working conditions information were obtained from a questionnaire survey. Results Geometric mean concentration (±standard deviation) of urinary 1-OHP among painting workers (587.9 ± 3.45 ng/g creatinine) was approximately 6.9 times higher than that among office workers (85.6 ± 2.09 ng/g creatinine; P value 0.20 was used for removal. Pearson’s correlation analyses were conducted to estimate the correlation between 1-OHP and iPF, with and without adjustments for age, smoking status, and alcohol consumption or not. Urinary 1-OHP and iPF levels were natural log-transformed for multiple linear regression and Pearson’s correlation analyses, because they were highly skewed with a long righthand tail. A P value
