1,3-Dipolar cycloadditions of azomethine imines.

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Organic & Biomolecular Chemistry View Article Online

DOI: 10.1039/C5OB01086A

1,3-Dipolar Cycloadditions of azomethine imines

Published on 24 June 2015. Downloaded by University of North Dakota on 24/06/2015 17:35:40.

Carmen Nájera,* José M. Sansano and Miguel Yus

Azomethine imines are considered 1,3-dipoles of the aza-allyl type which are transient intermediates and should be generated in situ but can be also stable and isolable compounds. They react with electron-rich and electron-poor olefins as well as with acetylenic compounds and allenoates mainly by a [3+2] cycloaddition but they can also take part in [3+3], [4+3], [3+2+2] and [5+3] with different dipolarophiles. These 1,3-dipolar cycloadditions (1,3-DC) can be performed under thermal or microwave conditions but also using metallo- and organocatalytic systems. In recent years enantiocatalyzed 1,3-dipolar cycloadditions have been extensively considered and applied to the synthesis of a great variety of dinitrogenated heterocycles with biological activity. Acyclic azomethine imines derived from mono and disubstituted hydrazones could be generated by prototropy under heating or by means of Lewis or Brønsted acids to give, after [3+2] cycloadditions, pyrazolidines and pyrazolines. Cyclic azomethine imines, incorporating a C-N bond in a ring, such as isoquinolinium imides are the most widely used dipoles in normal and inverse-electron demand 1,3-DC allowing the synthesis of tetrahydro-, dihydro- and unsaturated pyrazolo[1,5-a]isoquinolines in racemic and in enantioenriched form with interesting biological activity. Pyridinium and quinolinium imides give the corresponding pyrazolopyridines and indazolo[3,2a]isoquinolines, respectively. In the case of cyclic azomethine imines with a N-N bond incorporated in a ring N-alkylidene-3-oxo-pyrazolidinium ylides are the most popular stable and isolated dipoles able to form dinitrogen-fused saturated and unsaturated pyrazolopyrazolones as racemic or enantiomerically enriched compounds present in many pharmaceuticals, agrochemicals and other useful chemicals.

Departamento de Química Orgánica, Facultad de Ciencias, and Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain

Organic & Biomolecular Chemistry Accepted Manuscript

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Azomethine imines are 1,3-dipoles of the allylic type, which present two type of resonance structures, iminium imide and diazonium ylide.1-4 They are readily accessible as stable compounds or as intermediates for the synthesis of diverse dinitrogenated heterocycles by means of 1,3-dipolar cycloadditions (1,3-DC) under thermal or catalyzed conditions.2-12 Numerous type of pharmaceuticals, agrochemicals and other biologically active compounds can be prepared by means of different type of [3+2] cycloadditions, mainly with alkenes and alkynes, but also high order cycloadditions, such as [3+3], [4+3] and [3+2+3] have been recently developed. The asymmetric processes have been performed using chiral substrates, chiral metal complexes or organocatalysts.13-15 In this review we summarized the diverse type of azomethine imines (Scheme 1) which have been used as 1,3-dipoles in the last ten year, not only in racemic, but also in asymmetric processes. They have been classified according to the Schantl’s review10 covering literature until 2003.

Scheme 1 Typical azomethine imines.

2 Acyclic azomethine imines These types of dipoles have been postulated as intermediates in [3+2] cycloaddition reactions and are derived from hydrazones and carbazates (Scheme 1) leading to pyrazolines and pyrazolidines, and their derivatives. The corresponding precursors can be prepared from monosubstituted and 1,2disubstituted hydrazines.



1 General introduction

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2.1 From monosubstituted hydrazines Azomethine imines derived from acyclic hydrazones are generated easily upon 1,2-prototropy either under heating by Lewis acid catalysis or by protonation, and can be trapped with different dipolarophiles to afford five-membered dinitrogenated heterocycles through inter- and intramolecular cycloadditions.16-18 Normally, electron-deficient dipolarophiles are used, but also simple alkenes in the case of intramolecular processes.10 A recent intramolecular process has been applied to the synthesis of androstenoarylpyrazolines 3 using BF3·OEt2 as Lewis acid, previously used for intermolecular cycloadditions (Scheme 2).20 The reaction takes place stereoselectively at 0 °C in high yields from the corresponding hydrazones 1 by a BF3-promoted formation of intermediate azomethine imines 2.

Scheme 2 Intramolecular BF3-catalyzed [3+2]-cycloaddition of hydrazones with alkenes.

Three-component or consecutive intermolecular 1,3-DC of azomethine imines with αoxoketenes 5 has been performed under thermal conditions. Both, hydrazones and dipolarophiles are generated in situ, affording the corresponding pyrazolidinones 6 in a stereoselective manner (Scheme 3).21a Intermediate dipolarophiles 5 are generated from 2-diazo-1,3-diones 4 under


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microwave heating. When isatins are used as carbonyl precursor the corresponding spirooxindoles 7 are obtained in a stereoselective manner (Scheme 3).

Scheme 3 1,3-DC of hydrazones with α-oxoketenes.

Recently, a microwave-assisted intramolecular 1,3-DC of azomethine imines, in situ generated from indole-2-carboxaldehydes 8 and phenylhydrazine has been described. This process takes place in the presence of HCl as additive in ethanol, providing [a]-annelated pyrazolopyrroloindoles 9 in a regio- and stereoselective manner (Scheme 4).21b The reaction in presence of other additives such as AcOH, BF3·OEt2 or iodine gave either lower yields or no reaction.


4

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Scheme 4 Synthesis of pyrazolopyrrolinodoles by intramolecular 1,3-DC.

The stereocontrolled synthesis of cis-cyclopentanopyrazolidines has been carried out from the α-methoxy-α,β-unsaturated ester 10 bearing an α-keto ester at the end of the chain (Scheme 5).22 In the case of using thiosemicarbazide the intermediate azomethine imine is generated under heating giving the tricyclic thiohydantion 11. N-Acyl or N-alkoxycarbonyl hydrazines gave under thermal conditions the corresponding cycloadducts 12 in good yields (Scheme 5). This approach was previously described by the same group to prepare potential precursors of palau’amine (Scheme 6).23

Scheme 5 Synthesis of cis-cyclopentanopyrazolidines by intramolecular 1,3-DC.



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Scheme 6 Synthesis of a precursor of palau’amine.

The high stereoselectivity observed in these cycloadditions can be explained by formation of a chairlike transition state 15, which favors the overlap between the π-orbitals of the dipole and dipolarophile (Scheme 7).

Scheme 7 Proposed mechanism for the formation of cycloadducts 12.

Alternatively, it was possible to prepare the corresponding hydrazones 16 from 10 using a catalytic amount of HCl in ethanol at room temperature, and then the 1,3-DC takes place at ambient temperature in the presence of one equivalent of FeCl3 in dichloromethane, giving products 12 in good yields (Scheme 8).22

Scheme 8 FeCl3-Promoted 1,3-DC of hydrazones 16.



6

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The first example of a catalytic asymmetric intramolecular [3+2] cycloaddition of hydrazones with olefins was performed in the presence of a chiral zirconium catalyst.24 Different 4nitrobenzoylhydrazones 17 gave trans-pyrazolidines 18 with high diastereo- and enantioselectivity in the presence of Zr(Oi-Pr)4 (10 mol%) and the Binol derivative 19 at room temperature in dichloromethane (Scheme 9).

Scheme 9 Asymmetric intramolecular 1,3-DC of hydrazones 17 using a chiral Zr-Binol catalyst.

The same chiral catalyst formed by Zr(Oi-Pr)4 and Binol 19 has been used in the intermolecular [3+2] cycloaddition of benzoylhydrazones 20 and electron-rich alkenes like the ketene dimethyl dithioacetal 21. The corresponding 3,5-disubstituted pyrazolidines 22 were obtained in good yields and enantioselectivities (Scheme 10).25 In the case of vinyl ethers or thioethers 23 compounds 24 were obtained in low to moderate diastereoselectivity and high enantioselectivity. Samarium diiodide reduction of 24 afforded the corresponding 1,3-diamines, whereas LiAlH4 gave pyrazolidines.


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Scheme 10 Asymmetric intermolecular 1,3-DC of benzoylhydrazones 20.

A chiral silicon Lewis acid has been used in the intermolecular 1,3-DC of benzoylhydrazones 20 with vinyl ethers 23 (Scheme 11).26 The process needs 1.5 equivalents of compound 25, derived from pseudoephedrine, to take place giving the corresponding pyrazolidines 24 at room temperature in high trans-diastereoselectivity and excellent ee. The intermediacy of the complex 26, isolated and characterized by X-ray crystallography,27 explain the approach of the ether by the Si face of the hydrazone (27). Samarium diiodide reduction of pyrazolidines 22 gave the corresponding anti-1,3-diamines.



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9

N R1

Ph

O Ph

NH H

HN N +

25 (1.5 equiv) PhMe, rt

R1

23

20


OR2

24 (66-84%) dr = 95:5-97:3 ee = 90-98% Ph

O Si N Me

Ph Cl

25 R1 N H N Ph Ph Si O _ O +H Cl N Ph Me Me 26

OR2

H R1

H R O H H N N Ph Si O Ph _ O +H Cl N Ph Me Me 2

27

Scheme 11 Chiral silicon Lewis acid mediated 1,3-DC of benzoylhydrazones 20.

Hydrazones derived from ethyl glyoxylate and aliphatic or aromatic aldehydes react with cyclopentadiene (28) at room temperature in the presence of TMSOTf (10 mol%) as catalyst. The enantiocatalytic process was next assayed with an in situ generated Binol-phosphate derived silicon Lewis acid from 30 and Ph2SiCl2 (Scheme 12).28 Cycloadduct 29 was obtained in high syn/anti diastereomeric ratio (95:5) and up to 89% ee, but in a low yield (13%).


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10

N


Et

NO2

H N H

O

O 30 (15 mol%) Ph2SiCl2 (10 mol%) PhMe, -20 ºC, MS

+

20 (R1 = Et; Ar = 4-NO2C6H4)

H N

HN Et

28

H

29 (13%)

O P O

O OH

30

Scheme 12 First catalytic asymmetric 1,3-DC of hydrazones 20 with cyclopentadiene.

The asymmetric Brønsted acid catalyzed 1,3-DC of benzoylhydrazones 20 could be efficiently performed with cyclopentadiene (28) and α-methylstyrenes 31 as dipolarophiles (Scheme 13).29 Different Binol-derived phosphoric acids (pKa 13-14 in acetonitrile) were initially assayed as organocatalysts giving very low yields. However, the more acidic [H8]-Binol-based Ntrifluorophosphoramides 33 (pKa 6-7 in acetonitrile) gave pyrazolidines 29 and 32, respectively, in high yields and enantioselectivities. Cycloadducts 29 were isolated mainly as cis-diastereomers, whereas α-methylstyrene adducts 32 were obtained as single diastereomers. The cycloaddition product 29 with R = t-Bu was transformed by SmI2 reduction into a 1,3-diamine with a core structure similar to the influenza drug peramivir.30 By oxidation of cycloadduct 32 (R = t-Bu) with copper(II) chloride the corresponding pyrazoline was obtained maintaining the ee value.


NO2

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Scheme 13 Chiral N-triflylphosphoramide-catalyzed 1,3-DC of N-benzoylhydrazones 20.

However, for the [3+2] cycloaddition of N-benzoylhydrazones 20 with ethyl vinyl ether 23 (R = Et) the [H8]-Binol derived N-triflylphosphoramide 34 was the optimized catalyst. The corresponding cis-pyrazolidines 24 (XR2 = OEt) were obtained in good yields and enantioselectivities (Scheme 14).31 However, for the cycloaddition with ethyl vinyl thioether 23 (XR2 = SEt) the Spinol-derived N-triflylphosphoramide 35 was the best organocatalyst affording pyrazolidines 24 (XR2 = SEt) in good yields, diastereo- and enantioselectivities. 2



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Scheme 14 N-Triflylphosphoramides as chiral organocatalysts in the intermolecular 1,3-DC of benzoylhydrazones 20.

The mechanism of N-triflylphosphoramide-catalyzed asymmetric [3+2] cycloadditions was explored with DFT (MO6-2X) calculations.31 Protonation of hydrazones 20 by these Brønsted acids produces ion-pair complexes, which are more reactive than those formed from azomethine imines by 1,2-prototropy of the hydrazone through the transition state I (Scheme 15). These ionpairs hydrazonium-phosphoramide anions are reactive in [3++2] cycloadditions and only small distortion32 of them are required in the transition state II giving in this case the cis-pyrazolidines 24. The origin of enantioselectivities was also explained.



12

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Scheme 15 Uncatalyzed and catalyzed 1,3-DC of hydrazones and olefins.

2.2 From 1,2-disubstituted hydrazines The condensation of 1,2-disubstituted hydrazines and N-substituted carbazates or hydrazides with carbonyl compounds generates in situ directly the corresponding acyclic azomethine imines,33 which can be trapped in situ by dipolarophiles through an inter- or intramolecular [3+2] cycloaddition.10 In this case, they react preferentially with electron-deficient dipolarophiles under thermal conditions. Intermolecular 1,3-DC of azomethine imines 37, generated in situ from aldehydes and N1alkyl-N2-acyl hydrazines 36, takes place with electron-deficient dipolarophiles under refluxing toluene using a Dean-Stark trap (Scheme 16).34 The corresponding 3,4-disubstituted pyrazolidines 38-40, derived from benzaldehyde were obtained as a mixture of cis/trans diastereomers in low yields.



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Scheme 16 Thermal intramolecular 1,3-DC of azomethine imines derived from hydrazine 36.

The first and the only example of an enantiocatalytic three-component 1,3-DC of aldehydes, hydrazides and alkynes was performed using a PyBox 45/Cu(I) complex as catalyst and a chiral binaphthyl dicarboxylic acid 46 as cocatalyst (Scheme 17).35 N1-Benzylbenzoylhydrazide 41 was used for the generation of the corresponding azomethine imine intermediates 42, which react with terminal alkynes affording pyrazolines 43 in a chemoselective manner (>95:5), only small amounts of compounds 44 resulting from the nucleophilic addition of copper acetylide to 42 were also obtained. Aromatic and aliphatic aldehydes can be used in the presence of 4Å MS to eliminate the water formed during the condensation step. Moreover, aromatic and aliphatic alkynes can be used as well affording the corresponding pyrazolines 43 in high enantioselectivities (Scheme 17).



14

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Scheme 17 Three-component enantiocatalytic 1,3-DC of hydrazide 41 with aldehydes and acetylenes.

A representative 3,4-disubstituted pyrazoline 43a (with R1 = R2 = Ph) was further transformed into different heterocyclic compounds 47 and 48, as well as the diamine 49 by reduction of the last one with samarium diiodide (Scheme 18).



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Scheme 18 Synthetic applications of pyrazoline 43a.

3 Cyclic azomethine imines incorporating C-N in the ring Several types of heterocyclic systems with C-N double bond incorporated in a ring are a subclass of azomethine imines (Scheme 1).10 These types of dipoles have been extensively studied allowing the synthesis of different ring-fused pyrazolidines, pyrazolines, and pyrazoles. 3.1 Heterocyclic hydrazones derived azomethine imines Few examples have been describes using heterocyclic azomethine imines mainly in intramolecular processes. Heterocyclic azomethine imines of the type 51 can be prepared from the corresponding aldehydes 50 bearing a halogen atom at the γ- or δ-position. A cascade cyclization and 1,3-DC gave all-cis tricyclic compounds 52 in high yields (Scheme 19).36

H _

CHO Cl ( )n 50 [n = 1,2]

RNHNH 2 PhMe, reflux

+ N N R ( )n 51

N R N H ( )n 52 (75-98%)

Scheme 19 Cascade cyclization and 1,3-DC of hydrazones derived from 50.



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Azomethine imines 54 can be prepared by MW heating of benzoylhydrazides 53 bearing an alkyne in the chain through an intramolecular hydroamination reaction (Scheme 20).37 The reactivity of one example 54a with methyl acetylenedicarboxylate gave the fused pyrazoline 55 in moderate yield.

O F 3C

O

NH HN F 3C

_

F 3C R1

N

110-160 ºC, MW PhCF3

R2

( )n

R2

54 (44-93%)

O

O F 3C

_

N + N

+ ( )n N

F3C

53 [n = 1,2]

F3C

R1

MeO2C

CO2Me N N

CO2Me

CO2Me

PhMe, reflux F 3C

F 3C 54a

55 (45%)

Scheme 20 Synthesis of azomethine imines by intramolecular hydroamination.

3.2 Isoquinolinium-N-aryl imides N-Iminoisoquinolin-2-ium ylides 57 are the most recently used cyclic azomethine imines bearing a C-N bond in the ring.10 They have been mainly used in metal-catalyzed [3+2] cycloadditions not only with electron-deficient dipolarophiles but also with electron-rich alkenes. In addition, organocatalyzed processes, including asymmetric ones, have also been studied. A direct access to this type of intermediates is the cascade cyclization reaction of the aldehyde 56 with hydrazines to afford azomethine imines 57,38 which can be trapped in situ with N-phenylmaleimide (NPM) (Scheme 21).36 Cycloadducts 58 were obtained as mixture of endo:exo diastereomers (2:1-3:1). The reaction of the aldehyde 56 with benzylhydrazine in the presence of dimethyl maleate gave the cycloadduct 59 with all-cis relative configuration. The same 3:1 mixture of cycloadducts 60 was obtained by reaction of the aldehyde 56 with hydrazine hydrate in the presence of dimethyl maleate or fumarate. In the case of dimethyl acetylenedicarboxylate a 5:1 mixture of diastereomeric fused pyrazolines 61 were isolated under toluene reflux (Scheme 21).


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Scheme 21 Cascade cyclization 1,3-DC of hydrazines derived from 56.

Already prepared C,N-cyclic azomethine imines 57 (with R = Bz) were used for the first time as dipole in enantiocatalyzed [3+2] cycloadditions using enals 62 as dipolarophiles and titanium binolate complexes as catalysts (Scheme 22).38 The 2:1 (S)-Binol/Ti(Oi-Pr)4 complex gave at 0 ºC the corresponding exo-cycloadducts 63 in high yields, diastereo-, and enantioselectivities. Structurally related C,N-cyclic azomethine imines 65 were prepared in situ from 64 under basic conditions using 2,6-di-tert-butyl-4-methylpyridine (DTMP) as base compatible with the Lewis acid as catalyst. The resulting cycloadducts 66 were obtained mainly as exo-adducts with βsubstituted enals (62, R2 = H), whereas β-unsubstituted enals (62, R3 = H) gave mainly endocycloadducts 67 (Scheme 22).



18

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Scheme 22 Enantiocatalyzed 1,3-DC of C,N-cyclic azomethine imines with enals.

Samarium diiodide-mediated N-N cleavage of the adduct 66a (with R1 = R2 = H, R3 = Me) gave the tetrahydroisoquinoline 68 (Scheme 23).38

Scheme 23 Reductive N-N bond cleavage of compound 66a.

The same type of metal-catalyzed 1,3-DC of the azomethine imine 57 with unsaturated nitriles 69 was performed using a dicationic nickel(II) complex containing bis{(R)-1-[(SP)-2(diphenylphosphino)ferrocenyl]ethyl}cyclohexylphosphine [(R,SP)-Pigiphos] 71 as catalyst (Scheme 24).39 The [3+2] cycloaddition gave compounds 70 mainly as the endo-diastereomer in good yields and enantioselectivities.



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Scheme 24 Ni-Pigiphos-catalyzed 1,3-DC of C,N-cyclic azomethine imines 57 with unsaturated nitriles.

Asymmetric inverse-electron-demand 1,3-DC of C,N-cyclic azomethine imines 57 with tertbutyl vinyl ether could be performed firstly with the chiral dicarboxylic acid 74 as Brøsted acid (Scheme 25).40 The corresponding adducts 72 were obtained with different regioselectivity by interaction of the LUMO of the dipole with the HOMO of the alkene. Moreover, exo-cycloadducts 72 were obtained in high yields and enantioselectivities. Vinilogous aza-enamines gave mainly exocycloadducts 73 in high yields and good enantioselectivities. The hydrazone unit of compound 73 (with R1 = Br, R2 = H) was transformed into the corresponding cyano group by magnesium monoperoxyphthalate in 80% yield.



20

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Scheme 25 Organocatalyzed asymmetric 1,3-DC of cyclic azomethine imine 57 with electron-rich alkenes.

The thermal [3+2] cycloaddition reaction of azomethine imines 57 with α-substituted allenoates 75 occurs under mild reaction conditions to provide adducts 76 as a mixture of diastereomers in high regioselective manner (Scheme 26).41 The major endo-diastereomer could be separated and isolated by flash chromatography or by recrystallization. In the case of γ-substituted allenoates 77 the 1,3-DC takes place in lower yields giving mainly exo-cycloadducts 78.



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Scheme 26 Thermal [3+2] cycloaddition of azomethine imines 57 with allenoates.

When the same 1,3-DC was carried out in the presence of a trialkyl phosphine as catalyst (20 mol%) two different reaction pathways, [3+2] and [4+3] cyclizations depending on the phosphine and the allenoate were observed. In the case of α-alkyl substituted allenoates only [3+2] cycloaddition products 79 were obtained independently of the phosphine used (Scheme 27).42 However, α-benzyl substituted allenoates gave mainly the diazepine derivatives 80 through a [4+3] cycloaddition.



22

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R33P (20 mol%) 2

[R = alkyl] + N _ NBz

R1 Published on 24 June 2015. Downloaded by University of North Dakota on 24/06/2015 17:35:40.

N R1

57 + R2 C

NBz

H

R2

EtO2C 79 (60-93%) CH2Cl2 rt

CO2Et 75

n-Bu3P (20 mol%) 2

[R = aryl]

N R

1

H

NBz R2 CO2Et

80 (42-93%)

Scheme 27 Phosphine-catalyzed [3+2] versus [4+3] cycloadditions of azomethine imines 57 with allenoates 75.

However, when γ-substituted allenoates 77 are used as dipolarophiles the phosphinecatalyzed 1,3-DC with azomethine imines 57 gave the [3+2] cycloaddition. This process has been carried out with the ferrocenyl diphosphine 82 as chiral catalyst affording tetrahydroisoquinoline derivatives 81 in good yields, high exo-diastereoselectivities and moderate to high enantioselectivities (Scheme 28).43


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Scheme 28 Enantiocatalyzed [3+2] cycloaddition of azomethine imines 57 with γ-substituted allenoates 77 by the chiral phosphine 82.

Based on previous experiments about the formation of phosphonium-inner salts by reaction of allenoates with phosphines,44-46 the zwiterionic intermediates 83 and 84 were proposed. Intermediate 84 underwent δ-addition to the azomethine imine 57 to give 85 (Scheme 29).43 Intramolecular Michael addition gave 86, which after [1,2] proton transfer afforded intermediate 87. Final elimination of the phosphine catalyst yielded the cycloadduct 81.

Scheme 29 Mechanism of the phosphine-catalyzed [3+2] cycloaddition of 57 with 77.

Triflyl alkynes 88 gave 1,3-DC by reaction with azomethine imines 57 at room temperature, and after oxidative aromatization, pyrazoleisoquinoline triflones 89 were regioselectively obtained (Scheme 30).47


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A [4+3] cycloaddition has been observed when 1,2-diaza-1,3-dienes 91, generated in situ from the corresponding α-halo hydrazones 90, are allowed to react with C,N-cyclic azomethine imines 57 (Scheme 31).48 These 1,2-diaza-1,3-dienes 91 behave differently than azaenamines, which gave [3+2] cycloaddition with 57 (Scheme 25).40 In this case, an unprecedent [4+3] cycloaddition afforded highly functionalized 1,2,4,5-tetrazepine derivatives 92, which were obtained under mild reaction conditions.

Scheme 31 [4+3] Cycloaddition of azomethine imines 57 with diazadienes 91.

In the case of isocyanides 93 these azomethine imines 57 experimented a [5+1] cycloaddition at room temperature leading to the corresponding imino-1,3,4-oxadiazin-6-one derivatives 94 in high yields (Scheme 32).49 Related C,N-cyclic azomethine imine 64 not fused to the aromatic ring also gave this [5+1] cycloaddition with tert-butyl isocyanide in the presence of DTBMP as a base affording product 95 (Scheme 32).49

+ + CNR2 N _ NCOAr

R1 57

[R2 = t-Bu]

N 1

R

R2N

93

+ + CNt-Bu N _ NBz 93 64

CH2Cl2, rt

N

O

94 (34-99%)

N

CH2Cl2, rt DTBMP

t-BuN

N

O

95 (81%)

Ph

Ar



Scheme 30 [3+2] Cycloaddition of 57 with triflyl alkynes 88.



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Amine-catalyzed enantioselective [3+2] cycloadditions of aldehydes with azomethine imines 57 lead to the formation of adducts 97 (Scheme 33).50 Intermediate enamines formed with the chiral prolinol silyl ether 99 gave intermediate products 96, which after water attack afforded compounds 97. These hemiaminals were reduced in situ with sodium borohydride to 1-substituted tetrahydroisoquinolines 98 in high diastereo- and enantioselectivities.

Scheme 33 [3+2] Cycloaddition of azomethine imines 57 and aldehydes organocatalyzed by the chiral silylated prolinol 99.

The same group performed an enantioselective 1,3-DC using an intermediate dienamine 57 and enals (R2 = aryl), and a silylated prolinol 102 as organocatalyst. By subsequent reduction of the aldehyde functionality the corresponding alcohols 100 were isolated in good yields, diastereo- and enantioselectivities (Scheme 34).51 However, when aliphatic enals (R2 = alkyl) were used, regioisomeric derivatives 101 were obtained according to the formation of α,β-unsaturated iminium ion as intermediates. Similar iminium-dienamine reactivity has been reported independently with prolinols 99 and 102 by Alemán and Fraile.52



Scheme 32 [5+1] Cycloaddition of compounds 57 with isocyanides.

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Scheme 34 [3+2] Cycloaddition of compound 57 with enals organocatalyzed by the chiral silylated prolinol 102.

A new type of 1,3-DC has been recently performed with azomethine imines 57 and Nacyliminium ions 105 affording cycloadducts 103 (Scheme 35).53 The chiral Lewis base 104 acted as organocatalyst forming the corresponding activated intermediates 105 by reaction with mixed anhydrides.



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O Ar

1. BzCl, DIPEA, CH2Cl2 OH

2. 57, 104 (10 mol%)

N R1

H


Ar

NBz O

103 (59-95%) dr = 91:9->98:2 ee = 76-99% _

Ar S

N Ph

N

104

ArCH2COOCOPh

O + N

Ph

S N

105

Scheme 35 1,3-DC of compounds 57 with mixed anhydrides catalyzed by a chiral Lewis base 104.

Another family of isoquinolinium ylides are the corresponding unsaturated systems which should be prepared in situ in a two- or three-component reactions. Thus, N’-(2alkynylbenzylidene)hydrazides 106 react with bromine and α,β-unsaturated ketones via a threecomponent reaction to afford either 6-bromo-4H-pyrazolo[5,1-a]isoquinolines 108 in NMP at 70 ºC in the presence of DABCO as base, or 6-bromo-1,2,3-10b-tetrahydropyrazolo[5,1-a]isoquinolines 109 in DMAc at room temperature in the presence of potassium phosphate as base (Scheme 36).54 These processes took place by a bromine-promoted 6-endo-cyclization to give the isoquinolinium2-yl amide 107 followed by a [3+2] cycloaddition with the α,β-unsaturated carbonyl compound followed by aromatization. The same group has shown that H-pyrazolo[5,1-a]isoquinolines present promising activity as protein tyrosine phosphatase inhibitor.


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Scheme 36 Three-component reaction of hydrazides 106 with bromine and enones.

When the former process was carried out with 2-alkynyl benzaldehydes 110, ptoluenesulfonyl hydrazide and unsaturated carbonyl compounds in the presence of bromine or iodine, the multicomponent reaction afforded isoquinolines 108 with alkyl groups at the 1 and 5 positons.55 A similar process has been performed using AgOTf as catalyst, which after a 6-endo-dig cyclization produced the isoquinolinium-2-yl imide 111. The three-component reaction between 2alkynyl benzaldehydes 110, tosyl hydrazide and α,β-unsaturated carbonyl compounds gave functionalized H-pyrazolo[5,1-a]isoquinoline-1-carboxylates 112 (Scheme 37).56



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30

R4 + TsNHNH 2

1

R

OR3

R2 110


+

O

AgOTf (5 mol%) DCE/DMAc, 60 ºC _

+ NTs N R2

R1 111

R4

R3O2C

N N R1

R2

112 (50-90%)

Scheme 37 Silver triflate-catalyzed three-component reaction of 2-alkynyl benzaldehydes 110, tosyl hydrazide and α,β-unsaturated esters.

When an acetylenic dipolarophile is used, only a halogen or silver triflate promotes the [3+2] cycloaddition. Thus, N’-(2-alkynylbenzylidene)hydrazides 106 react with acetylenes either catalyzed by silver triflate or promoted by bromine or iodine in the presence of NaOAc. In the case of dimethyl acetylenedicarboxylate (DMAD) either in the presence of AgOTf or bromine the fused dihydroisoquinolines undergo a rearrangement involving a N-N homolysis to give compounds 113 or 114, respectively (Scheme 38).57 However, in the presence of iodine the fused 1,2dihydroisoquinolines 115 are obtained.


CHO

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Scheme 38 Reaction of hydrazones 106 with dimethyl acetylenedicarboxylate.

The same process in the presence of terminal acetylenes gave the H-pyrazolo[5,1a]isoquinolines 116 (X = H)58a in the case of AgOTf or 116 (X = Br, I)58b first by a bromine or iodine promoted cyclization followed by a silver-catalyzed nucleophilic addition of the acetylide to give the isoquinolinium-2-yl imide of the type 117 (Scheme 39). However, when this process is carried out in the presence of tosyl azide with silver triflate and copper(I) bromide, as cocatalyst, 5sulfonylamine-substituted isoquinolines 117 were obtained (Scheme 39).59



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32

N-Allyl ynamides reacted with N’-(2-alkynylbenzylidene)hydrazides 106 in a process catalyzed by silver triflate and palladium acetate generating 2-amino-H-pyrazolo[5,1a]isoquinolines 118 in good yields (Scheme 40).60 In this case, the [3+2] cycloaddition takes place, after the silver-promoted cyclization to give azomethine imines 111, with ynamido-palladium πallyl complexes 119 affording intermediates 120. Subsequently, an intramolecular [3,3]-sigmatropic rearrangement produces compound 121, which undergoes aromatization releasing a tosyl group.

Scheme 40 Synthesis of compounds 118 by AgOTf and Pd(OAc)2 catalyzed cascade reaction of hydrazides 106 with N-allyl ynamides.

An alternative route to pyrazoloisoquinolines 116 (X = H) used brooalkynes as dipolarophiles. In this case, the alkynylation of 111, formed by the silver-catalyzed cyclization of 106, takes place by a C-H activation. The bromoalkyne is activated via oxidative addition to CuI, which through a concerted metallation-deprotonation process would give intermediates 122. After reductive elimination, intermediates 123 undergo a 5-endo-dig-cyclization to give 124, followed by subsequent aromatization to form the final H-pyrazolo[5,1-a]isoquinolines 116 (Scheme 41).61



Scheme 39 Reaction of hydrazides 106 with alkynes.

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Scheme 41 Reaction of N-iminoisoquinolinium ylides 111 with bromoalkynes.

2-Trifluoromethylpyrazolo[5,1-a]isoquinolines 125 can be prepared from N’-(2alkynylbenzylidene)hydrazides 106 and ethyl 4,4,4-trifluorobut-2-ynoate by means of the tandem silver triflate catalyzed cyclization and [3+2] cycloaddition of the corresponding Niminoisoquinolinium ylides 111 (Scheme 42).62

Scheme 42 Synthesis of compounds 125 by a [3+2] cycloaddition of N-iminoisoquinolinium ylides 111.



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In the case of the silver triflate-catalyzed cyclization of compounds 106 in the presence of the in situ generated pyridyne 127 from 126, the corresponding regioisomeric H-pyrazolo[5,1a]isoquinolines 128 and 129 were prepared in modest yields (Scheme 43).63a Polyfluoroarenes react with N’-(2-alkynylbenzylidine) hydrazide 106 catalyzed by silver triflate in the presence of cesium carbonate leading to polyfluoroaryl-fused H-pyrazolo[5,1-a]isoquinolines in good yields.63b Recently, it has been described the three-component reaction of aldehydes 110, sulfonyl hydrazide and benzyne affording the corresponding H-pyrazolo[5,1-a]isoquinolines in very good yields (8398%).63c

Scheme 43 Reaction of compound 106 with pyridyne 127.

Propargyl amines give [3+2] cycloadditions with N-iminoisoquinolinium ylides 111 generated in situ from hydrazides 106, to give the corresponding H-pyrazolo[5,1-a]isoquinolines 130 bearing an aminomethyl substituent at the 5-position (Scheme 44).64

Scheme 44 Synthesis of compounds 130 from propargyl amines.

Silyl enol ethers have been used as dipolarophiles with N-iminoisoquinolinium ylides 111, generated in situ from hydrazides 106. Thus, the tandem process affords the 5,6-disubstituted Hpyrazolo[5,1-a]isoquinolines 131 in good yields (Scheme 45).65



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Scheme 45 Reaction of hydrazides with silyl enol ethers.

The multicomponent reaction of 2-alkynyl benzaldehydes 110, tosyl hydrazide, methanol and α,β-unsaturated aldehydes catalyzed by silver triflate gave H-pyrazolo[5,1-a]isoquinolines 132 with excellent regioselectivity (Scheme 46).66 Preliminary biological assays of these compounds show promising activity as CDC25B, TC-PTP, and PTP1B inhibitors.

Scheme 46 Synthesis of compounds 132 from 2-alkynyl benzaldehydes 110.

Similarly, the bromine-promoted cyclization of hydrazides 106 afforded the brominated Niminoisoquinolinium ylides 107, which also react with α,β-unsaturated aldehydes in the presence of methanol to give the fused brominated isoquinolines 133 (Scheme 47).67



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Scheme 47 Bromine promoted cyclization of hydrazides 106 and [3+2] cycloaddition with α,βunsaturated aldehydes.

Based on the former methods for the in situ generation of isoquinolinium-2-yl imides 134, these azomethine imines have been recently prepared and isolated by the one-pot reaction of 2alkynyl benzaldehydes 110, hydrazides and final silver triflate catalyzed cyclization (Scheme 48).68

Scheme 48 Synthesis of isoquinolinium-2-yl imides 134.

A silver-catalyzed process involving 2-alkynyl benzaldehydes 110, tosyl hydrazide and carbonyl compounds is a simple and direct strategy for the synthesis of H-pyrazolo[5,1a]isoquinolines 131 (Scheme 49).69

Scheme 49 One-pot tandem reaction of 2-alkynyl benzaldehydes, tosylhydrazide and carbonyl compounds.



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Alternatively, by using primary alcohols and hydrazides 106 instead of aldehydes 110, the presence of the Dess-Martin reagent (DMP) as oxidant is compulsory to afford 6-monosubstituted H-pyrazolo[5,1-a]isoquinolines 135 (Scheme 50).70a,b

Scheme 50 Tandem reaction of hydrazides 106 with alcohols.

The same transformation can be performed by a silver triflate-palladium chloride cooperative catalysis. The presence of oxygen promotes the palladium-catalyzed oxidation of the alcohol to the corresponding aldehyde or ketone. The in situ generated enolate attacks the isoquinolinium-2-yl imide followed by condensation and aromatization to afford products 135 in 47-90% yield.70c Silver triflate-copper(II) acetate cooperative catalysis has been used for the cyclization/[3+2] cycloaddition of N’-(2-alkynylbenzylidene) hydrazides 106 with allenoates 77 in the presence of dioxygen to afford H-pyrazolo[5,1-a]isoquinolines 136 (Scheme 51).71a The proposed mechanism involves a peroxy-copper(III) intermediate 138, which evolves to 139 and, after elimination of Cu(II)-OH generates a carbonyl compound 140. Final aromatization yielded products 136 in moderate to good yields. When this reaction was performed with Ph3P as catalyst the corresponding isoquinolines 136 were obtained with a R3CH2 group instead of the ketone functionality.71b


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Scheme 51 Reaction of hydrazides 106 with allenoates 77 in the presence of dioxygen cocatalyzed by silver triflate and copper(II) acetate.

Silver-rhodium(I) cooperative catalysis has been used for the reaction of hydrazides 106 with cycloprop-2-ene-1,1-dicarboxylate72 or with 2-vinyloxirane73 for the synthesis of the corresponding H-pyrazolo[5,1-a]isoquinolines 141 or 142, respectively (Scheme 52). The use of the Wilkinson catalyst is crucial for the [3+2] cycloaddition.



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Scheme 52 Silver-rhodium(I) cooperative catalysis in the reaction of 106 with cycloprop-ene-1,1dicarboxylate or 2-vinyloxirane.

When silver triflate and copper(II) chloride are used as cooperative catalysts it is possible to prepare H-pyrazole[5,1-a]isoquinolines 135 through a three-component process. Thus, 2-alkynyl benzaldehydes, tosyl hydrazide and tertiary amines in air gave products 135 by a silver-catalyzed cyclization and copper(II)-catalyzed oxidation of an aliphatic C-H bond of the tertiary amine in air (Scheme 53).74 A related process using palladium dibromide as cocatalyst gave isoquinolines 131, which has been performed starting from the hydrazides 106 instead of aldehydes 110 (Scheme 53).75a The same transformation has been previously performed using Fe2(CO)9 as cocatalyst (5 mol%) and tert-butyl hydroperoxide (3 equiv) affording products 135 in 46-83% yields.75b



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40

Methylene indolinones have been used as dipolarophiles for the diastereoselective construction of fused H-pyrazolo[3,2-a]isoquinolines 143 as a mixture of diastereomers (Scheme 54).76 In this case, the Wu et al.56 methodology was applied to a process starting from N’(alkylnylbenzylidene) hydrazides 106 under silver-catalyzed 6-endo cyclization to generate the Niminoisoquinolinium ylide 111.

Scheme 54 Preparation of fused spirooxindoles 143.

In general, these unsaturated isoquinolinium imideshave been mainly used in [3+2] cycloaddition with acetylenic dipolarophiles. The only example of a [3+3] cycloaddition of azomethine imines 144 has been described using cyclopropane diesters and a Ni(ClO4)2 complex with a trisoxazoline derivatives 146 as chiral ligand.77 This process allows the preparation of 6,6,6tricyclic dihydroisoquinoline derivatives 145, in general with high diastereo- and enantioselectivities (Scheme 55). This reaction is based on the non-asymmetric example described previously by Charette et al.78 with N-benzoyliminoisoquinolinium ylide and methyl 2phenylcyclopropane-1,1-dicarboxylate catalyzed by Ni(ClO4)2 in modest yield (21%).



Scheme 53 Amines as reagents for the synthesis of compounds 131 and 135.

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Scheme 55 Enantiocatalyzed [3+3] cycloaddition of azomethine imines 144 and cyclopropane diesters.

3.3 Pyridinium- and quinolinium imides Pyridinium imides 147, also called N-iminopyridinium ylides or pyridin-N-imines, are masked cyclic azomethine imines incorporating C-N in the ring, which react mainly with acetylenic dipolarophiles.10 They are unstable and have to be generated in situ from N-aminopyridinium halides and since the aromaticity of pyridine is broken after the cycloaddition, they have to be oxidized to give the desired product. A greater stability can be achieved by introducing an electronwithdrawing group such as acyl, alkoxycarbonyl, or sulfonyl to afford ylides 148. NBenzoyliminopyridinium ylides 150 have been the most used imines of this family. They can be prepared by benzoylation of the corresponding N-aminopyridinium salts 149 (Scheme 56) easily accessible by direct N-amination of pyridine using hydroxylamine-O-sulfonic acid.79-81 Alternatively, N-aminopyridinium salts 147 can be prepared using different electrophilic amination reagents, especially efficient being O-(2,4-dinitrophenyl) hydroxylamine, which gave good yields with several types of substituted pyridines, quinolines and isoquinolines.82



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Scheme 56 Synthesis of N-benzoyliminopyridinium ylides 150.

By using alkynes as dipolarophiles pyrazolopyridines can be prepared83 which exhibit a wide range of biological activities including dopamine D3 receptor antagonist and partial agonist,84 dopamine D4 antagonist,85 as well as adenosine A1 receptor antagonist,86 and antiherpetic87 and antiallergenic88 properties. Consequently, they are applicable in the treatment of neurological disorders such as schizophrenia, attention-deficit disorder, and Parkinson’s disease. Polystyrene-bound alkenes 152 have been used for the solid-phase synthesis of pyrazolopyridines 153 by in situ generation of pyridinium imides 147 from N-aminopyridinium salts 151 followed by TFA cleavage (Scheme 57). Alternatively, by using NaOMe in THF/MeOH the corresponding methyl esters can be isolated.89

Scheme 57 Solid-phase synthesis of pyrazolopyridines 153 by a [3+2] cycloaddition of pyridinium imides with polymer-bound propiolates 152.



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In the case of using arynes as dipolarophiles and pyridinium imides 148 with different electron-withdrawing groups on the imide nitrogen, it was found that the pyrido[1,2-b]indazoles 155 are obtained in high yields (Scheme 58) using the tosyl derivatives 154, whereas the benzoyl, pivaloyl, benzyloxycarbonyl, and tert-butyloxycarbonyl ones gave lower results.90 This methodology has been also used with N-tosylisoquinolinium imides to afford indazolo[3,2a]isoquinolines.

Scheme 58 Synthesis of pyrido[1,2-b]indazoles 155 by aryne [3+2] cycloaddition with N-tosyl pyridinium imides.

The thermal [3+2] cycloaddition of N-benzoylquinolinium imide 156 with allenoates 75 provides products 157 in good yields, albeit with poor diastereoselectivity (Scheme 59).91 This cycloaddition has been carried out with N-benzoylisoquinolinium imides with similar results, concerning yield and diastereoselectivity.

R + N_ N 156

+

C

CO2Et

H N N

PhMe 90 ºC Bz

COPh 75

CO2Et R

157 (65-96%) drtrans:cis = 41:59-74:26

Scheme 59 Thermal [3+2] cycloaddition of N-benzoylquinolinium imide 156 with allenoates.

A formal [3+2] cycloaddition catalyzed by a gold complex 159 between Nbenzoyliminopyridinium ylides 158 and N-alkynylsulfonamides gave 2,4,5-trisubstituted oxazoles 160 in high yields (Scheme 60).92


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Scheme 60 Gold-catalyzed formal [3+2] cycloaddition of N-benzoyliminopyridinium ylides 158 with N-alkynyl sulfonamides.

The benzocondensed azomethine imines 156 have been employed in [3+3] cycloadditions. Thus, the nickel-catalyzed [3+3] cycloaddition of N-benzoylquinolinium imide 156 with 1,1cyclopropane diesters provided products 161 in modest to good yields and moderate diastereoselectivity (Scheme 61).78 This cycloaddition has been also performed with the Nbenzoylisoquinolinium ylide with modest yield (21%).

Scheme 61 Ni-catalyzed formal [3+3] cycloaddition of quinolinium imides and 1,1-cyclopropane diesters.

An enantioselective formal [3+3] cycloaddition has been performed also with Nbenzoylpyridinium ylides 158 and silylated enol diazoacetates 162 using the rhodium catalysts 164. Bicyclic dearomatized 1,2,3,6-tetrahydropyridazine derivatives 163 were obtained in high yields and enantioselectivities (Scheme 62).93 The reaction is triggered by Rh(II)-catalyzed dinitrogen extrusion with formation of a rhodium carbenoid intermediate followed by addition of the pyridinium ylide.



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Scheme 62 Rh-catalyzed formal [3+3] cycloaddition of N-acylpyridinium ylides 158 with silylated enol diazoacetates 162.

4 Cyclic azomethine imines incorporating a N-N bond in a ring The most studied cyclic azomethine imines incorporating a N-N bond in a ring are N-alkylidene-3oxopyrazolidinium imides 166, which are stable and readily accessible. They have been employed as 1,3-dipoles in thermal and metallo- or organo-catalyzed cycloadditions not only [3+2] but also [3+3], [4+3] and [3+2+3] ones. These annulations reactions gave rise to dinitrogen-fused heterocycles including tetrahydropyrazolo-pyrazolones, -pyridazinones, -diazepinones, and – diazocinones, which are important products or intermediates for the preparation of useful chemicals and diverse bioactive molecules.

4.1 N-Alkylidene-3-oxopyrazolidin-1-ium-2-ides Azomethine imines 166, derived from pyrazolidin-3-ones 165, are usually prepared by condensation with carbonyl compounds.10 They can be isolated, especially in the case of aromatic aldehydes, by heating in anhydrous methanol catalyzed by means of trifluoroacetic acid (Scheme 63).10,94

Scheme 63 Synthesis of azomethine imines 166 from pyrazolidin-3-ones 165.



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A recent new route to azomethine imines has been described using hydrazones derived from ketones and N-alkoxycarbonylhydrazines 167 and alkenes (Scheme 64).95 Under microwave assisted heating at 150 ºC the intermediate isocyanate is formed and through a concerted alkene aminocarbonylation pathway the corresponding azomethine imines 168 are produced in good yields. Several type of acyclic and cyclic alkenes can be used including vinyl ethers and enamides. With terminal alkenes (R4 = H) a total regioselectivity was observed.

Scheme 64 Synthesis of azomethine imines 168 from hydrazones 167 and alkenes.

4.1.1 Thermal cycloadditions A common reaction of azomethine imines 169 with dipolarophiles such as methyl propiolate or dimethyl acetylenedicarboxylate gave the corresponding cycloadducts 2,3-dihydro-1H,5Hpyrazolo[1,2-a]pyrazol-1-ones 170 (Scheme 65).94

Scheme 65 [3+2] Cycloaddition of azomethine imines 169 with alkynes.

Stereoselective synthesis of fused pyrazolones have been studied with racemic pyrazolidin3-one 171, which after reaction with benzaldehydes and followed by [3+2] cycloadditions of the generated azomethine imines 172 with electron-deficient dipolarophiles such as methyl acrylate, dimethyl acetylene dicarboxylate and dimethyl maleate, pyrazolopyrazolone derivatives 173-175 were obtained with high stereocontrol (Scheme 66).96,97 The stereoselective cycloaddition of azomethine imines 172 with maleimides provided cycloadducts 176 when the aldehydes has not substituents at the ortho-position. However, with ortho-substituted aldehydes diastereomeric adducts 177 were formed.98,99 Similarly, butyraldehyde and acetone react with pyrazolidinone 171 under acid-catalyzed process to afford the corresponding azomethine imines, which react under



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thermal conditions with dimethyl acetylenedicarboxylate, methyl acrylate, methyl maleate or fumarate and N-phenylmaleimide to give the corresponding cycloadducts.100

NHCOPh


Ph

O

ArCHO

+

HN NH 171 TFA cat. EtOH reflux NHCOPh Ph

O + _ N N

H Ar 172

CO2Me

MeO2C

MeO2C

O N N

Ar

MeO2C NHCOPh

Ph

MeO2C

O N N

MeO2C Ar

MeO2C

CO2Me

Ar

Ph

O

RN N N Ar

Ph

O

O

O

NHCOPh

175 (49-68%)

174: Ar = Ph (86%)

173 (68-88%)

O N N

MeO2C

NHCOPh

CO2Me

NHCOPh Ph

176 (48-75%)

O

RN N N

O Ar

NHCOPh Ph

177 (18-89%)

Scheme 66 Diastereoselective [3+2] cycloaddition of azomethine imines 172 with dipolarophiles.

In the case of the Cu(I)-catalyzed [3+2] cycloaddition of azomethine imines 172 (Ar = Ph) it takes place at room temperature in acetonitrile using the Hünig’s base with methyl propiolate giving the product 178 (Scheme 67).101 When the chiral ynone 179 was allowed to react with 172 a mixture of diastereomeric cycloadducts 180 was obtained.


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Scheme 67 Diastereoselective Cu(I)-catalyzed [3+2] cycloaddition of azomethine imine 172 with acetylenic dipolarophiles.

Azomethine imines 166 and 172 derived from unsubstituted 165 and substituted 171 pyrazolidin-3-ones, respectively, have been used as dipoles in the reaction with α(trifluoromethyl)acrylates affording the corresponding adducts with moderate diastereoselectivity.102 In the case of alkynyl Fischer carbene complexes a regioselective [3+2] cycloaddition takes place giving, after oxidative demetallation, the corresponding functionalized pyrazolopyrazolone derivatives 182 (Scheme 68).103

Scheme 68 [3+2] Cycloaddition of azomethine imines 166 with alkynyl Fischer carbene complexes.



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Several pyrazolidin-3-ones bearing a chiral chain have been applied as precursors of chiral azomethine imines in diastereoselective [3+3] cycloadditions. Thus, 5-substituted pyrazolidin-3ones 183 derived from 2,3-unsaturated sugar 1,5-lactones, react at room temperature with acetone and then with dimethyl acetylenedicarboxylate (DMAD) to provide either the cycloadduct 184 or with two equivalents of DMAD, under camphorsulfonic acid (CSA) catalysis, to give mainly the cycloadduct 185 (Scheme 69).104

Scheme 69 Diastereoselective [3+2] cycloaddition of 183 with DMAD.

The intramolecular [3+2] cycloaddition of azomethine imine 187 derived from pyrazolidin3-one 165 (R1 = R2 = R3 = R4 = H) and the glucose-derived aldehyde 186, gave the diazatriquinane 188 (Scheme 70).105 This methodology has been studied with different sugar-derived hexen-5-als giving the corresponding diazatriquinanes in high yields and total stereocontrol, which were used for biological screening.

Scheme 70 Synthesis of polyoxygenated diazatriquinane 188 via intramolecular diastereoselective [3+2] cycloaddition.



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Different type of dipolarophiles have been investigated under thermal conditions with azomethine imines 166 derived from unsubstituted 165, among them, acetylenic sulfones,106 arynes,107 β-nitrostyrenes,108 cyclic vinyl sulfones,109 and trifluoroethylidene malonates.110 In the case of using azlactones 189 as dipolarophiles, a [3+2] cycloaddition, followed by a rearrangement at room temperature, gave the pyrazolopirazolone derivatives 190 (Scheme 71).111 The cycloadduct intermediates 191 are unstable and rearranged giving 190 with high diastereoselectivity (>20:1).

Scheme 71 [3+2] Cycloaddition of azomethine imines 166 with azlactones 189.

4.1.2 Copper-catalyzed cycloadditions In 2003 Fu et al. described for the first time that CuI (5 mol%) catalyzed the cycloaddition of the azomethine imine 166 (R1 = Ph) with ethyl acrylate at room temperature in the presence of 0.5 equivalents of Cy2NMe in dichloromethane giving regioselectively the corresponding cycloadduct in 88% yield. After establishing these reaction conditions, different chiral ligands were assayed, the phosphaferrocene oxazoline 193 giving the highest enantioselectivity for cycloadducts 192 in the reaction with terminal alkynes (Scheme 72).112 The same reaction conditions have been applied to the kinetic resolution of racemic substituted azomethine imines 166 (Scheme 73).113


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Scheme 72 Enantioselective copper-catalyzed [3+2] cycloaddition of azomethine imines ylides 166 with terminal alkynes.

Scheme 73 Kinetic resolution of azomethine imines via a copper-catalyzed [3+2] cycloaddition.

The [3+2] cycloaddition of azomethine imines 169 with the N-acryloylpyrazolidinone 194 catalyzed by the chiral complex Cu(OTf)2·bisoxazoline 196 gave regio- and diasteroselectively exocycloadducts 195 in good yields (Scheme 74).114 These processes have been performed only with this pyrazolidinone 194 able to be chelate by the copper complex and different C5-substituted azomethine imines.



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Scheme 74 Enantioselective copper-catalyzed [3+2] exo-cycloaddition of azomethine imines 169 with the pyrazolidinone 194.

The chiral bis(imidazolidine) 198·CuOAc complex has been used as catalyst for the [3+2] cycloaddition of the azomethine imine 169 with propiolates affording cycloadducts 197 with modest enantioselectivities (Scheme 75).115

Scheme 75 Enantioselective copper-catalyzed [3+2] cycloaddition of azomethine imines 169 with propiolates using ligand 198.

The same group developed a better ligand PyBodine (L-Ala) 199 able to perform this cycloaddition with Cu(OAc)2 as metallic salt in better yields and enantioselectivities (Scheme 76).116



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Scheme 76 Enantioselective copper-catalyzed [3+2] cycloaddition of 169 with propiolates using ligand 199.

Group 11 metal amides, copper(I) and silver bis(trimethylsilyl)amides (HMDS) in THF catalyzed the same [3+2] cycloaddition of 166 with terminal alkynes with opposite regioselectivity. This process has been performed in an enantioselective manner when (S)-DIP-BINAP ligand 201 was used with CuHMDS. Thus, the corresponding 5,7-disubstituted cycloadducts 200 were obtained in good yields and enantioselectivities (Scheme 77).117,118 This regioselectivity is explained by 1,2-addition of the copper acetylide to the iminium moiety followed by intramolecular cyclization.

Scheme 77 Enantioselective copper-catalyzed [3+2] cycloaddition of azomethine imines 166 with terminal alkynes.

By using propiolylpyrazoles 202 as acetylenic dipolarophiles terminal and internal alkynes gave very good enantioselection in the [3+2] cycloaddition of azomethine imines 166 catalyzed by a chiral π-cation catalyst 204 (Scheme 78).119 The main difference in this type of copper catalyst



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compared to the previous ones is that the copper(I) acetylide-mediated cycloaddition of azomethine imines with terminal alkynes is not operating (Method A). Instead, a Lewis acid-catalyzed cycloaddition by coordination with the carbonyl group (Method B) takes place (Scheme 79).

Scheme 78 Enantioselective copper-catalyzed [3+2] cycloaddition of 166 with propiolylpyrazoles catalyzed by the chiral complex 202.

Scheme 79 Strategies for the copper-catalyzed [3+2] cycloaddition of azomethine imines 166 with alkynes.

The racemic copper-catalyzed [3+2] cycloaddition has been performed not only with CuI but also with Cu(I) zeolites as the heterogeneous ligand-free catalysts.120,121 They are easy to be removed by simple filtration and can be recycled up to six times without decreasing efficiency. Heterogeneous supported copper hydroxide Cu(OH)x/Al2O3 has been used also as an efficient reusable catalyst.122


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The catalytic asymmetric cross-1,3-DC of two different dipoles, azomethine ylides, generated from iminoesters 205 and imines 166, gave highly substitutd 1,2,4-triazinanes with total diastereo- and enantioselectivity. (S, SP)-t-Bu-Phosferrox 207 as ligand and AgOAc or Cu(MeCN)BF4 salts have been assayed as chiral catalysts for this [3+3] cycloaddition. The best results were obtained with the Cu complex giving the cycloadducts 206 in high yields, diastereo(>20:1) and enantioselectivities (Scheme 80).123

Scheme 80 Enantioselective copper-catalyzed [3+3] cycloaddition of azomethine ylides and azomethine imines.

Independently, a similar [3+3] cycloaddition has been performed using the ferrocenyl P,Nchiral ligand 208 and Cu(MeCN)4ClO4 salt as catalyst. This process takes place giving products 206 with good yields (71-89%), diastereo- (>20:1) and enantioselectivities (50-96%).124

Isocyanides 209 and azomethine imines 169 gave a [3+3] cycloaddition to give pyrazole[1,2-a]triazin-8(4H)-ones 210 (Scheme 81).125 The process takes place with high stereocontrol using CuI as catalyst and DBU as base at room temperature. Silver salts and other copper salts provided lower yield than CuI. The proposed mechanism involves the formation of the α-cuprioisocyanide followed by nucleophilic addition to the imine and final insertion of the isonitrile 211 into the N-Cu bond to give the imidoyl-copper intermediate 212 and final protonation.


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O

O _

R2 R

+ N N

3

+

CN


R1

209

R4

CuI (20 mol%) DBU (20 mol%) CHCl3, rt

R2 R3

[R4 = CO2Et, Ts]

169

N

N N

R4 R1

210 (40-93%)

R4

CN

[Cu] O R

2

R3 R

N [Cu] N NC 1

O 2

R

R3

N R1

4

R 211

[Cu]

N

R4

212

Scheme 81 [3+3] Cycloaddition of azomethine imines 169 and isocyanides 209 catalyzed by CuI.

4.1.3 Other metal-catalyzed cycloadditions Enantioselective nickel-catalyzed 1,3-DC between azomethine imines 169 and 3-acryloyl-2oxazolidinone 213 takes place using (R)-binaphthyldiimine 215 as chiral ligand to provide cycloadducts trans- and cis-214 (Scheme 82).126 The process gave mainly the trans-diastereomers with a high level of enantioinduction acting the metal complex as chiral Lewis acid coordinating the Ni(II) atom the acryloyloxazolinone. A dipole-HOMO/dipolarophiles-LUMO controlled asymmetric 1,3-DC is proposed.


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Scheme 82 Enantioselective Ni(II)-catalyzed [3+2] cycloaddition of azomethine imines 169 and 3acryloyl-2-oxazolidinone 213.

Recently, a Ni(II)-catalyzed enantioselective [3+2] cycloaddition of azomethine imine 166 and alkylidene malonates as dipolarophiles has been described. In this case trans-pyrazolone derivatives 216 have been obtained with total diastereoselectivity and good enantioselectivities by using a chiral N,N’-dioxide 217 as chiral ligand (Scheme 83).127 The reaction also proceeds by a dipole-HOMO/dipolarophiles-LUMO interaction, the Ni-complex acting as chiral Lewis acid coordinating the two carbonyl groups of the alkylidene malonate.

Scheme 83 Enantioselective Ni(II)-catalyzed [3+2] cycloaddition of the azomethine imine 166 and alkylidene malonates.



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The palladium-catalyzed [3+3] cycloaddition of trimethylenemethane (TMM) with azomethine imines 166 led to the formation of six-membered cycloadducts 219.128 Starting from [2(acetoxymethyl)-2-propenyl]trimethylsilane 218, the Pd-TMM complex reported by Trost,129 generated from Pd(PPh3)4 in DCM gave the best results (Scheme 84). Azomethine imines bearing substituents on the pyrazolidinone ring can also be used in this [3+3] cycloaddition giving the hexahydropyridazines with high diastereoselectivity. However, using substituted TMM different products are formed.

Scheme 84 Palladium-catalyzed [3+3] cycloaddition of trimethylenemethane with the azomethine imines 166.

Gold-catalyzed [3+3] cycloadditions of azomethine imines 166 and propargyl esters have been observed to proceed by a stepwise mechanism with a gold(III) carbenoid 221 as intermediate. The reaction takes place in the presence of 5 mol% of picolinate-gold dichloride (159) as catalysts affording adducts 220 with moderate to high diastereoselectivity (Scheme 85).130

Scheme 85 Gold(III)-catalyzed [3+3] cycloaddition of azomethine imines 166 with propargyl esters.



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N-Allenyl amides 222 underwent 1,3-DC of azomethine imines 166 under gold(I) catalysis to provide [3+2] cycloadducts 223 (Scheme 86).131 This process can occur through a gold allene intermediate, which can give another intermediate 224 by an outer-sphere nucleophilic addition. Subsequent intramolecular cycloaddition of 224 yielded the iminium intermediate 225, which after deauration, gave the final cycloadduct 226.

Scheme 86 Gold(I)-catalyzed [3+2] cycloaddition of 166 with N-allenyl amides 222.

The asymmetric 1,3-DC of azomethine imines 166 to allyl alcohol was possible using stoichiometric amount of a strong Lewis acid formed by diisopropyl (R,R)-tartrate (DIPT) and an being an excess (3 equiv) of butylmagnesium bromide necessary for the deprotonation of allyl alcohol to form the intermediate 228. The reaction proceeds at 80 ºC in acetonitrile affording only the corresponding trans-pyrazolinonepyrazolidines 227 (Scheme 87).132,133


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Scheme 87 Enantioselective [3+2] cycloaddition of azomethine imines 166 with allyl alcohol catalyzed by magnesium diisopropyl (R,R)-tartrate.

Under similar reaction conditions homoallylic alcohols have been used for this type of [3+2] cycloaddition. In this case only 20 mol% of DIPT, one equivalent of MgBr2 and 1.5 equivalents of n-BuMgCl were used providing also the trans-cycloadducts 230 in 23-93% yield and 63-93% ee.133,134 In the proposed transition state 229, the azomethine imine is coordinated to magnesium by the nitrogen and the carbonyl group to afford pyrazolidinones 230 (Scheme 88). The same group has developed a desymmetrization of 1,4-pentadien-3-ol by the asymmetric 1,3-DC of azomethine imines using magnesium diisopropyl tartrate as chiral Lewis acid in up to 98% ee.135

Scheme 88 Enantioselective [3+2] cycloaddition of azomethine imines 166 and homoallyl alcohol catalyzed by magnesium diisopropyl tartrate.

Doyle et al. have studied enol diazoacetate 162 as dipolarophile for the [3+2] cycloaddition with azomethine imines 166 catalyzed by Sc(OTf)3 or In(OTf)3 as Lewis acids.136 The corresponding cycloadducts 232 are obtained diastereoselectively in good yields. Selective 1,2C→C and N→C migrations catalyzed by rhodium(II) salts or CuPF6 were observed to give six membered rings. However, using rhodium(II) acetate the corresponding [3+3] annulations products



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cis-231 were regio- and diastereoselectively obtained (Scheme 89).137 The azomethine imine attacks the vinylogous position of the Rh(II)-vinyl carbine 232 to give the intermediate 233, which after subsequent ring formation followed by extrusion of the catalyst gives the fused bicyclic pyrazolidinones 231.

Scheme 89 Rh-catalyzed [3+3] cyclization of enol diazoacetate 162 with azomethine imines 166.

When a diazoketone 234 was used as dipolarophile a formal [3+2+1] annulation with azomethine imines 166 was observed (Scheme 90).138 In this case, a similar intermediate metal carbine 232 (Scheme 89) is trapped by another molecule of the diazoketone 234 to give diastereoselectively products 235 by means of the chiral dirhodium(II) carboxamidate 236.


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Scheme 90 Rh(II)-catalyzed formal [3+2+1] annulations of azomethine imines 166 and diazoketone 234.


4.1.4 Metal-free-catalyzed cycloadditions Different types of Lewis bases such as amines, phosphines and Lewis and Brønsted acids have been used for the racemic and enantioselective 1,3-DC of azomethine imines with dipolarophiles. For electron-rich alkenes, such as vinyl ethers 23, highly reactive nitrosonium hexafluorophosphate must be used as catalyst for the [3+2] cycloaddition of azomethine imines 166 (Scheme 91). The corresponding fused pyridazinones 237 were obtained with low to good cis/trans diastereoselectivity.139

Scheme 91 NO cation-catalyzed [3+2] cycloaddition of azomethine imines 166 with vinyl ethers.

The first organocatalyzed asymmetric [3+2] cycloaddition of α,β-unsaturated aldehydes to azomethine imines 116 was carried out using the α,α-diarylprolinol salt 239. The enal activation takes place by iminium formation giving the corresponding fused pyrazolidinones 238 mainly with exo-selectivity and high enantioselectivities (Scheme 92).140 The possible reaction models for this 1,3-DC is illustrated in Scheme 92: both transition states A and B with s-cis and s-trans conformations, respectively, would afford the exo-cycloadducts.


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Scheme 92 Organocatalyzed enantioselective [3+2] cycloaddition of azomethine imines 166 with enals.

When this reaction is catalyzed by N-heterocyclic carbenes, a highly stereoselective formal [3+3] cycloaddition takes place to provide pyridazinones 240 (Scheme 93).141 The addition of the N-mesitylbenzimidazolyl carbene, generated from the benzimidazolium iodide 242, by an addition/acylation sequence with 166 affords the final bicyclic heterocycles 240.



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Scheme 93 NHC-catalyzed [3+2] cycloaddition of azomethine imines 166 with enals.

The enantioselective [3+2] cycloaddition of cyclic enones and azomethine imines 166 has been performed in the presence of the chiral primary amine 9-amino-9-deoxyepiquinine 244 and 2,4,6-triisopropylbenzenesulfonic acid (TIPBA) as catalyst (Scheme 94).142 The corresponding tricyclic pyrazolidinones 243 were obtained in good yields, diastereo- and enantioselectivities. The Cinchona derived catalyst activates the enone forming a ketiminium cation and an additional hydrogen bonding between the OH and the C=O groups to produce the endo and Re-face selectivities in the final cycloadducts.



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Scheme 94 Enantioselective organocatalyzed [3+2] cycloaddition of cyclic enones to 166.

The base-catalyzed diastereoselective [3+3] annulations of 3-isothiocyanatooxindoles 245 to azomethine imines 166 gave 3,3’-triazinnyl spirooxindoles 246 (Scheme 95).143 Using 1 mol% of triethylamine the reaction takes place in only five minutes at room temperature with high yields and diastereoselectivities.

O O _

+ N N R1 166

R

S

NCS

3

+

O N R2 245

Et3N (1 mol%) CHCl3, rt

R3

N N

HN

R1 O N R2 246 (75-94%) dr = 10:1->20:1

Scheme 95 Base-catalyzed [3+3] cycloaddition of isothiocyanatooxindoles 245 with 166.

Another example of a base-catalyzed [3+3] cycloaddition of azomethine imines 166 takes place with 1,4-dithiane-2,5-diol 247. DABCO catalyzes this process (Scheme 96) in methanol giving products 248 resulting from the attack of the base to mercaptoacetaldehyde followed by addition to the azomethine imine and subsequent intramolecular cyclization, the diastereoselectivity



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being controlled by the anomeric effect.144 5-Methyl and 5-phenyl substituted azomethines 166 gave the all cis-cycloadducts 248.

Scheme 96 DABCO-catalyzed [3+3] cycloaddition of mercapto acetaldehyde to 166.

The multicomponent synthesis of pyrazolidinones 249 has been performed starting from 165, the aldehyde and Meldrum’s acid. This process was organocatalyzed by (DHQ)2PHAL 250 acting as chiral base. A domino Knoevenagel-aza-Michael-cyclocondensation reaction gave the resulting cycloadducts 249 in good yields and enantioselectivities (Scheme 97).145

Scheme 97 Multicomponent enantioselective [3+2] cycloaddition of pyrazolidinones 165 with aldehydes and Meldrum’s acid.


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Nucleophilic phosphine catalysis has been used for different types of [3+n] cycloaddition of azomethine imines 166 with allenoates 77 (Scheme 98). These reactions take place by formation of various zwiterionic intermediates by addition of a phosphine as Lewis base to the β-carbon of the αallenic ester, affording five -, six-, seven-, and eight-membered dinitrogen containing heterocycles. These types of cycloadditions have been also studied with C,N-cyclic azomethine imines 57 (Scheme 27).42

Scheme 98 Phosphine-catalyzed [3+n] cyclization of azomethine imines 166 with allenoates.

Ethyl 2-methylbuta-2,3-dienoate 75 reacted with azomethine imines 166 under tri-nbutylphosphine-catalyzed [3+2] cycloaddition to afford the exocyclic alkylidene adducts 251 as single isomers (Scheme 99).146 By using a chiral phosphine 253, product 251 (with R1 = Ph) was obtained in 56% yield and 89% ee. When azomethine imine 166 [with R = 4-(O2N)C6H4] was allowed to react with other α-alkyl allenoates 75, trimethylphosphine was the catalyst of choice to prepare products 252. These 1,3-DC takes place by formation of the corresponding 1,3-zwiterionic intermediate 254.


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Scheme 99 Phosphine-catalyzed [3+2] cycloadditions of allenoates 75 with azomethine imines 166.

The reaction involving diethyl 2-vinylidene succinate 255 was more complicated giving mixtures of five-, six-, and seven-membered ring either with tri-n-butyl- or trimethylphosphine (Scheme 100).146 It has been proposed that zwiterionic intermediates A and B gave the five- and the six- or seven-membered ring, respectively.



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69

CO2Et

+ N N

+ C

CO2Et

Ar 255

166 Published on 24 June 2015. Downloaded by University of North Dakota on 24/06/2015 17:35:40.

[Ar = 4-O2NC6H4] PR3 (20 mol%) CH2Cl2, rt O

O

O

O CO2Et N

N

N

+ CO2Et

N

N

+ CO2Et

Ar

CO2Et

Ar

N

N

+

Ar

N

Ar CO2Et

EtO2C

EtO2C

256

257

258

259

Pn-Bu3

6%

23%

48%

15%

PMe3

40%

42%

7%

5%

+ PR3 _

CO2Et

+ PR3 CO2Et

CO2Et _

CO2Et

CO2Et

Scheme 100 Phosphine-catalyzed [3+2], [3+3] and [4+3] cycloadditions of azomethine imine 166 and diethyl 2-vinylidene succinate 255.

For unsubstituted ethyl 2,3-butadienoate 260, a mixture of [3+2] and [3+3] cycloadditions 261 and 262 are formed in different proportions depending on the phosphine used as catalyst. Trimethylphosphine favors the formation of the tetrahydropyrazolopyrazolone 261 and tri-nbutylphosphine the tetrahydropyrazolopyridazinone 262 by addition of the γ-carbon of the allenoate and the α-carbon, respectively (Scheme 101).146


O _



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Scheme 101 Phosphine-catalyzed [3+2] and [3+3] cycloaddition of azomethine imine 166 and ethyl 2,3-butadienoate 260.

When γ-substituted allenoates 77 are allowed to react with azomethine imine 166 [Ar = 4(O2N)C6H4] only the tetrahydropyrazolopyridazinones 263 were obtained in modest yields and with total diastereoselectivity, among other non-isolated products (Scheme 102).146

Scheme 102 Phosphine-catalyzed [3+3] cycloaddition of 166 with γ-substituted allenoates 77.

The reaction of ethyl 2,3-butadienoate 260 with different azomethine imines 166 was studied in more detail in order to determine the structure of secondary products. It was found out the formation of [3+2+3] products, such as 1-oxo-2,3,5,6-tetrahydro-1H-pyrazolo[1,2-a][1,2]diazines 264 and 265, mainly when tricyclohexylphosphine was used as catalyst (Scheme 103).146 In this case, experimental and theoretical studies support the participation of 1,5-zwiterionic intermediates 266, in order to explain the formation of the eight- and seven-membered rings through [5+3] and [5+2] cycloadditions, respectively.147



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71

O _

+ N N Ar


166

+

C

CO2Et

CH2Cl2, PhH, 0 ºC

260

N

N

PCy3 (20 mol%)

N

N

+

Ar

CO2Et

Ar EtO2C

EtO2C 264

+ PR3 CO2Et _

CO2Et 265

(51-92%) 264:265 = 44:56-9:91

CO2Et

266

Scheme 103 Phosphine-catalyzed [5+3] cycloaddition of 166 with ethyl 2,3-butadienoate.

However, under thermal conditions, only the [3+2] cycloaddition products 267 were formed in high yields (Scheme 104).41 Whereas with α-, and γ-substituted allenoates a complex mixture of products was obtained. When ethyl 2-butynoate was used instead of ethyl 2,3-butadienoate (260), the tri-n-butylphosphine-promoted cyclization with azomethine imines 166 afforded also a mixture of products 261 and 262 by intermediacy of the same 1,3-zwiterionic intermediate 254.148

Scheme 104 Thermal [3+2] cycloaddition of 166 with ethyl 2,3-butadienoate 260.

Electron-deficient alkenes such as the (Z)-1,2-bis(phenylsulfonyl)ethylene 268 gave under Ph2PMe-catalysis at room temperature the corresponding [3+2] cycloaddition products 269 in the reaction with azomethine imines 166 (Scheme 105).149 Products 269 were obtained with high diastereoselectivity and the relative configuration was the same when using (E)-268. In this case, the participation of the zwiterionic intermediate 270 has been proposed, which attacks the azomethine imine followed by intramolecular cyclization regenerating the phosphine. The same [3+2] cycloaddition has been observed with C,N-cyclic azomethine imines 57, as well as with 144 and 156.


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Scheme 105 Phosphine-catalyzed [3+2] cycloaddition of 166 with (Z)-bis-1,2bis(phenylsulfonyl)ethylene 268.

Chiral bis-phosphoric acid 272 has been used as Brøsted acid catalyst for the 1,3-DC of alkylideindolinones 271 with azomethine imines 166 to afford spiro pyrazolidin-3,3’-oxindoles 273 (Scheme 106).150 By MS and DFT calculation experiments the best transtition state has been established in which both the alkylideneindolines and the azomethine imines are hydrogen bounded with the OH group of both phosphoric acid moieties.

Scheme 106 Phosphoric acid-catalyzed the enantioselective [3+2] cycloaddition of 166 with alkylideneindolinones.



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The phosphoric acid 30 (Ar = 9-anthracenyl) has shown good diastereo- and moderate enantioselectivities in the organocatalyzed enantioselective inverse-electron-demanding 1,3-DC of azomethine imines 166 with o-hydroxy-α-methylstyrene 274. Thus, [3+2] cycloaddition takes place in 1,3-difluorobenzene giving mainly cycloadducts 275 through a two-step mechanism. The presence of the hydroxy group at the ortho position is crucial for the reaction to occur. A dual activation mode by hydrogen bonding interaction between the two substrates and the catalyst together with the conjugative effect initiated by the o-hydroxy group played an essential role in the proposed transition state A (Scheme 107).151

Scheme 107 Phosphoric acid-catalyzed enantioselective [3+2] cycloaddition of 166 with ohydroxy-α-methylstyrene 274.

4.2 N-Alkylidenepyrazolidin-1-ium-2-ides Azomethine imines 277 can be generated from the opening of the diaziridine ring in 1,5diazabicyclo[3.1.0]hexane 276 either by thermolysis152-154 or by means of scandium triflate and trapped by dipolarophiles to give products 278 (Scheme 108).155,156 This ring opening can be performed in ionic liquids (ILs) in the presence of BF3·Et2O and the resulting unstable azomethine imines can be trapped by nitro styrenes or chalcone to give the corresponding [3+2] cycloadducts 278 and 280, respectively (Scheme 109).157



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Scheme 108 [3+2] Cycloadditions of azomethine imines 277 generated from 1,5diazabicyclo[3.1.0]hexanes 276.

Scheme 109 [3+2] Cycloaddition of azomethine imines 277 with nitro styrenes and chalcone.

When acrylonitrile or 4-nitrophenyl vinyl sulfone were used as dipolarophiles the corresponding cycloadducts 281 or 282 were obtained with modest diastereoselectivity, and with opposite regioselectivity in the first case (Scheme 110).158,159



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Scheme 110 [3+2] Cycloaddition of azomethine imines 276 with acrylonitrile and 4-nitrophenyl vinyl sulfone.

4.3 N-Alkylidene 3-oxodiazolidin-1-ium-2-ides These type of azomethine imines has been less studied than the pyrazolidinium imides. Only glyoxylic azomethine imines derived from 283 have been investigated. These chiral six-membered hydrazide 283 react with aliphatic and aromatic aldehydes to give the corresponding azomethine imines, which react with diethyl acetylene dicarboxylate and olefinic dipolarophiles to provide pyrazolo[1,2-a]pyridazin-5(6H)-ones .10,160,161 When ethyl glyoxylate is used as carbonyl component in the presence of an excess of magnesium bromide etherate, the corresponding oxadiazolidine 284 is formed, which undergoes cycloreversion-cycloaddition in the presence of various electron-poor dipolarophiles such as styrenes giving cycloadducts 285 (Scheme 111).162 Methyl maleate, fumarate and crotonate as well as N-phenylmaleimide gave cycloadducts 286-289 with modest diasteroselectivities and good yields.



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Scheme 111 Diastereoselective [3+2] cycloadditions of chiral glyoxylic azomethine imine.

Conclusions In the last 10 years the chemistry of acyclic and especially cyclic azomethine imines, have experimented a renaissance in synthesis of heterocycles of wide structural diversity such as pyrazolidines, pyrazoloisoquinolines and pyrazolopyrazolones among others. Their reactivity in 1,3-dipolar cycloadditions (1,3-DC) with a great variety of dipolarophiles in high regio- and diastereoselectively manner have found many applications in the synthesis of dinitrogen heterocycles. Depending on the dipolarophile partially or totally saturated heterocycles can be prepared generally by a [3+2] cycloaddition but also by higher order cycloadditions. Most of the methodologies recently studied are in the field of the asymmetric synthesis using chiral Lewis bases and Brønsted acids as organocatalysts depending on the dipolarophile and metal complexes bearing chiral ligands. The study of asymmetric catalytic methods has just started and further synthetic applications to be developed in this field would be important in the next future.

Abreviations Ac:

acetyl

Bn:

benzyl



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Bz:

benzoyl

Cbz:

benzyloxycarbonyl

CSA:

camphorsulfonic acid

DABCO:

diazabicyclo[2.2.2]octane

DBU:

1,8-diazabicyclo[5.4.0]undec-7-ene

1,3-DC:

1,3-dipolar cycloaddition

DCE:

1,2-dichloroethane

DCM:

dichloromethane

DDQ:

1,3-dichloro-5,6-dicyano-1,4-benzoquinone

DFT:

density functional theory

DIPEA:

diisopropyl ethyl amine

DIPT:

disopropyl tartrate

DMAc:

N,N-dimethylacetamide

DMAD:

dimethyl acetylenedicarboxylate

DMF:

N,N-dimethylformamide

DMP:

Dess-Martin reagent

2,4-DNBA:

2,6-dinitrobenzoic acid

DTBMP:

2,6-di-tert-butyl-4-methylpyridine

HDMS:

hexamethyldisilazane

ILs:

ionic liquids

MS:

mass spectrometry

NMP:

N-methylpyrrolidone

NPM:

N-phenylmaleimide

Py:

pyridine

rt:

room temperature

SEM:

scanning electron microscopy

TBS:

tert-butyldimethylsilyl

TIPBA:

2,4,6-triisopropylbenzenesulfonic acid

TIPS:

triisopropylsilyl

TMM:

trimethylenemethane

TMSOTf:

trimethylsilyl triflate

Troc:

2,2,2-trichloroethoxycarbonyl

Ts:

p-toluenesulfonyl



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Acknowledgements We thank the continue financial support from our Ministerio de Ciencia e Innovación (MICINN (projects CTQ2007-62771/BQU, CTQ2010-20387, CONSOLIDER INGENIO 2010-CDS200700006, CTQ2011-24151, CTQ2011-24165), the Ministerio de Economía y Competitividad (MINECO) (projects CTQ2013-43446-P, CTQ2014-51912-REDC, CTQ2014-53695-P), FEDER, the Generalitat Valenciana (PROMETEO 2009/039, PROMETEOII/2014/017), and the University of Alicante.

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Carmen Nájera was born in Nájera (La Rioja) and was graduated from the University of Zaragoza in 1973, obtaining her doctorate in chemistry from the University of Oviedo in 1979. She spent postdoctoral stays at the ETH (Zurich), the Dyson Perrins Laboratory (Oxford), Harvard University, and Uppsala University. She became Associate Professor in 1985 at the University of Oviedo and Full Professor in 1993 at the University of Alicante. She is coauthor of more than 300 papers and book chapters and has supervised more than 40 PhD students. She has been awarded with the 2006 Organic Chemistry Prize from the Spanish Royal Chemical Society of Chemistry, the 2006 Rosalind Franklin International Lectureship from the English Royal Society, the SCF 2010 French-Spanish Prize from the Société Chimique de France and the IUPAC 2015 Distinguished Women in Chemistry or Chemical Engineering Award. In 2012 she was named full Member of the Royal Spanish Academy of Sciences, and was appointed as Active Member of the European Academy of Sciences and Arts.

José Miguel Sansano studied chemistry at the University of Alicante, where he obtained his B.Sc. and Ph.D. degrees in 1988 and 1994, respectively. His Thesis was supervised by Prof. C. Nájera and dealt about sulfone chemistry. After spending a two-year postdoctoral stay at the University of Leeds (U.K.) with Prof. R. Grigg, he joined the University of Alicante in 1996, where he was appointed Associate Professor in 2001. In 2010 he was promoted to Professor in the same University.



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Miguel Yus was born in Saragossa in 1947 and received his BSc (1969), MSc (1971) and PhD (1973) from the University of Saragossa. After spending two years as a postdoctoral fellow at the Max Plack Institut in Mülheim he became Associate Professor (1977) and Professor (1987) at the University of Oviedo. In 1988 he moved to his current position at the University of Alicante. He has been invited professor at ETH-Zürich, Oxford, Harvard, Uppsala, Tucson, Okayama, Paris, Strasbourg, Bologna, Sassari, Tokyo and Kyoto. Dr. Yus has authored more than 500 papers and five patents, has delivered around 200 lectures abroad and has supervised more than 60 PhD students. Among others he has receive the Spanish-French Prize (1999), twice the Japan Society for the Promotion of Science Prize (2000, 2007), the Stiefvater Memorial Lectureship Award (2001), the Conference Lourenco-Madinaveitia (1912), the Serratosa Lecctureship (2010) and the Medalla Felix Serratosa (2012), being Academician of the European Academy of Sciences and Arts (2012). He has been in the Advisory Bord of about 20 international journals and founded ten years ago the company MEDALCHEMY for the commercialization of fine chemicals.



86

[3 + 2]-Cycloadditions of Azomethine Imines and Ynolates.

Amine-catalyzed enantioselective 1,3-dipolar cycloadditions of aldehydes to C,N-cyclic azomethine imines.

Intramolecular polar [4(⊕)+2] cycloadditions of aryl-1-aza-2-azoniaallene salts: unprecedented reactivity leading to polycyclic protonated azomethine imines.

Desymmetrization of 1,4-pentadien-3-ol by the asymmetric 1,3-dipolar cycloaddition of azomethine imines.

Alkaloid-Catalyzed Enantioselective [3 + 2] Cycloaddition of Ketenes and Azomethine Imines.

N-heterocyclic carbene-catalyzed [3+4] cycloaddition and kinetic resolution of azomethine imines.

Organocatalytic asymmetric inverse-electron-demand 1,3-dipolar cycloaddition of N,N'-cyclic azomethine imines.

Enantioselective 1,3-dipolar cycloaddition of azomethine imines with propioloylpyrazoles induced by chiral π-cation catalysts.

Theoretical investigations of the reaction between 1,4-dithiane-2,5-diol and azomethine imines: mechanisms and diastereoselectivity.

[3 + 3]-cycloaddition reactions of α-acidic isocyanides with 1,3-dipolar azomethine imines.

Catalytic enantioselective 1,3-dipolar cycloadditions of azomethine ylides for biology-oriented synthesis.

Phosphine-catalyzed [3+2] cycloaddition reactions of azomethine imines with electron-deficient alkenes: a facile access to dinitrogen-fused heterocycles.

Catalytic chemoselective [3+3] cycloadditions of azomethine ylides with quinone monoimides leading to the construction of a dihydrobenzoxazine scaffold.

A phosphine-catalyzed novel asymmetric [3+2] cycloaddition of C,N-Cyclic azomethine imines with δ-substituted allenoates.

Phosphine-catalyzed highly enantioselective [3 + 3] cycloaddition of Morita-Baylis-Hillman carbonates with C,N-cyclic azomethine imines.

New Regio- and Stereoselective Cascades via Unstabilized Azomethine Ylide Cycloadditions for the Synthesis of Highly Substituted Tropane and Indolizidine Frameworks.

Activation of Dinitrogen as A Dipolarophile in 1,3-Dipolar Cycloadditions: A Theoretical Study Using Nitrile Imines as "Octet" 1,3-Dipoles.

Ring enlargement reaction of C,N-cyclic-N'-acyl azomethine imines with sulfonium ylide: an efficient synthesis of 3-benzazepine derivatives.

Asymmetric hydrogenation of imines.

Radical aminomethylation of imines.

Nitrone Cycloadditions of 1,2-Cyclohexadiene.

Cycloadditions of cyclohexynes and cyclopentyne.

18F-labeling using click cycloadditions.

Stereoselective tandem cascade furan cycloadditions.