JVI Accepts, published online ahead of print on 10 September 2014 J. Virol. doi:10.1128/JVI.01205-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
1
A bivalent vaccine based on a replication-incompetent influenza virus
2
protects against Streptococcus pneumoniae and influenza virus infection
3
Running title: Bivalent vaccine for respiratory infectious disease
4
Hiroaki Katsura1,*, Zhenyu Piao2,*, Kiyoko Iwatsuki-Horimoto1, Yukihiro Akeda2, Shinji Watanabe3,4,
5
Taisuke Horimoto5, Kazunori Oishi2,6,†, Yoshihiro Kawaoka1,3,7,8,‡
6 7
1
8
University of Tokyo, Tokyo, Japan
9
2
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,
Laboratory of Clinical Research on Infectious Diseases, International Research Center for Infectious
10
Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
11
3
12
Japan
13
4
14
Miyazaki, Japan
15
5
16
University of Tokyo, Tokyo, Japan.
17
6
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
18
7
Department of Pathobiological Sciences, School of Veterinary Medicine, University of
19
Wisconsin-Madison, 575 Science Drive, Madison, WI, USA
20
8
21
Medical Science, University of Tokyo, Tokyo, Japan
22
*These authors contributed equally to this work.
ERATO Infection-Induced Host Responses Project, Japan Science and Technology agency, Saitama,
Laboratory of Veterinary Microbiology, Department of Veterinary Sciences, University of Miyazaki,
Department of Veterinary Microbiology, Graduate School of Agriculture and Life Science,
Depertment of Special Pathogens, International Research Center for Infectious Diseases, Institute of
23 24
†,‡ Corresponding authors and mailing addresses:
25
†Kazunori Oishi 1
26
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
27
Phone: +81-3-5285-1111
28
Fax: +81-3-5285-1129
29
E-mail: [email protected]
30 31
‡Yoshihiro Kawaoka
32
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,
33
University of Tokyo, Tokyo, Japan.
34
Phone: +81-3-5449-5281
35
Fax: +81-3-5449-5408
36
E-mail: [email protected]
37 38 39
Abstract: 220 words (
1
A bivalent vaccine based on a replication-incompetent influenza virus
2
protects against Streptococcus pneumoniae and influenza virus infection
3
Running title: Bivalent vaccine for respiratory infectious disease
4
Hiroaki Katsura1,*, Zhenyu Piao2,*, Kiyoko Iwatsuki-Horimoto1, Yukihiro Akeda2, Shinji Watanabe3,4,
5
Taisuke Horimoto5, Kazunori Oishi2,6,†, Yoshihiro Kawaoka1,3,7,8,‡
6 7
1
8
University of Tokyo, Tokyo, Japan
9
2
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,
Laboratory of Clinical Research on Infectious Diseases, International Research Center for Infectious
10
Diseases, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
11
3
12
Japan
13
4
14
Miyazaki, Japan
15
5
16
University of Tokyo, Tokyo, Japan.
17
6
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
18
7
Department of Pathobiological Sciences, School of Veterinary Medicine, University of
19
Wisconsin-Madison, 575 Science Drive, Madison, WI, USA
20
8
21
Medical Science, University of Tokyo, Tokyo, Japan
22
*These authors contributed equally to this work.
ERATO Infection-Induced Host Responses Project, Japan Science and Technology agency, Saitama,
Laboratory of Veterinary Microbiology, Department of Veterinary Sciences, University of Miyazaki,
Department of Veterinary Microbiology, Graduate School of Agriculture and Life Science,
Depertment of Special Pathogens, International Research Center for Infectious Diseases, Institute of
23 24
†,‡ Corresponding authors and mailing addresses:
25
†Kazunori Oishi 1
26
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
27
Phone: +81-3-5285-1111
28
Fax: +81-3-5285-1129
29
E-mail: [email protected]
30 31
‡Yoshihiro Kawaoka
32
Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,
33
University of Tokyo, Tokyo, Japan.
34
Phone: +81-3-5449-5281
35
Fax: +81-3-5449-5408
36
E-mail: [email protected]
37 38 39
Abstract: 220 words (
