A Comparative Study of Ticarcillin plus Tobramycin Versus Carbenicillin plus Gentamicin for the Treatment of Serious Infections Due to Gram-Negative Bacilli
MICHAEL F. PARRY, M.D.
l
HAROLD C. NEU, M.D. New York, New York
From the Division of Infectious Diseases and Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York. Requests for reprints should be addressed to Dr. Harold C. Neu, Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032. Manuscript accepted November 28, 1977. *Present address: Stamford Hospital, Stamford, Connecticut 06902.
The combination of ticarcillin plus tobramycin (77) or carbenicillin plus gentamicln (CG) was used to treat 82 patlents with severe systemic gram-negative infection in a prospective, randomized study. Pseudomonas aeruginosa was the primary pathogen Pn 76 (93 per cent) of these patients. Patients treated wlth ll responded more frequently (92 per cent or 37 of 40) than patients treated wlth CG (71 per cent or 30 of 42) (p
MICHAEL F. PARRY, M.D.
l
HAROLD C. NEU, M.D. New York, New York
From the Division of Infectious Diseases and Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York. Requests for reprints should be addressed to Dr. Harold C. Neu, Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032. Manuscript accepted November 28, 1977. *Present address: Stamford Hospital, Stamford, Connecticut 06902.
The combination of ticarcillin plus tobramycin (77) or carbenicillin plus gentamicln (CG) was used to treat 82 patlents with severe systemic gram-negative infection in a prospective, randomized study. Pseudomonas aeruginosa was the primary pathogen Pn 76 (93 per cent) of these patients. Patients treated wlth ll responded more frequently (92 per cent or 37 of 40) than patients treated wlth CG (71 per cent or 30 of 42) (p
