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BJO Online First, published on February 18, 2016 as 10.1136/bjophthalmol-2015-307792 Clinical science

A comparison of endothelial and penetrating keratoplasty outcomes following failed penetrating keratoplasty: a registry study Miriam C Keane, Rachel A Galettis, Richard A D Mills, Douglas J Coster, Keryn A Williams, for Contributors to the Australian Corneal Graft Registry Department of Ophthalmology, Flinders University, Adelaide, South Australia, Australia Correspondence to Professor Keryn A Williams, Department of Ophthalmology, Flinders University, Flinders Medical Centre, Bedford Park, SA 5042, Australia; keryn.williams@flinders.edu.au Received 4 September 2015 Revised 27 January 2016 Accepted 31 January 2016

ABSTRACT Purpose To compare graft survival and visual outcomes for endothelial keratoplasty (EK) after a first penetrating keratoplasty (PK), with outcomes of repeat PK after a first PK. Methods 400 eyes with a second graft (65 EKs, 335 PKs) performed after failure of a primary PK were identified through the Australian Corneal Graft Registry, a national prospectively followed cohort. Grafts were performed after January 2008 (follow-up of the second graft extending to 6.75 years maximum). Kaplan–Meier graft survival plots were constructed and Cox proportional hazards regression was used to identify independent risk factors for graft failure. Best-corrected Snellen visual acuity (BCVA) at last follow-up was compared with pregraft acuity. Results Poor Kaplan–Meier graft survival was observed for PK-EK compared with PK-PK (log-rank=29.66, p

A comparison of endothelial and penetrating keratoplasty outcomes following failed penetrating keratoplasty: a registry study.

To compare graft survival and visual outcomes for endothelial keratoplasty (EK) after a first penetrating keratoplasty (PK), with outcomes of repeat P...
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