International JoBrIlal Of Applied Radiation and Isotopes, 1977, Vol. 28, pp. 255-261. Pergamon Press. Printed in Northern Ireland
A new approach to target chemistry for the iodine-123 production via the l 'Te(p, 2n) reaction R. V A N D E N BOSCH,* J. J. M. D E G O E I J , t $ J. A. V A N D E R H E I D E , * J. F. W. T E R T O O L E N , § H. M. J. T H E E L E N t and C. Z E G E R S . ¢ (Received 1 April 1976)
A method is described for a routine production of sizeable quantities of iodine-123 for medical diagnosis. The iodine-123 is produced via a (p, 2n) reaction on enriched tellurium124 targets. Results are presented for relevant excitation functions. A new approach to target chemistry--comprising target preparation, separation of tellurium and carrier-free radioiodine, and target-material recovery--is presented. Irradiation techniques and chemical procedures are described in some detail.
INTRODUCTION Trm ~Dwa,rrAG~S of iodine-123 over iodine131 for some in vivo diagnostic p r o c e d u r e s - which may be completed within 24 hr or less--have now been widely recognized. The iodine-123 may be produced via a number of nuclear reactions involving various natural or enriched targets, various bombarding particles and bombarding energies from a few MeV to tens of MeW. (1'2" 3, 4, 5,6, 7) At the Eindhoven University of Technology a project was started to produce iodine-123 for local users on a routine scale with the university A V F cyclotron. A description of the cyclotron, the maximum energy of which is 30 MeV for protons, is given elsewhere. (s) In this study we have decided in favor of proton activation of tellurium. According to our own measurements and published results of Acerbi et al. (2) and Wolf et al.
A new approach to target chemistry for the iodine-123 production via the l 'Te(p, 2n) reaction R. V A N D E N BOSCH,* J. J. M. D E G O E I J , t $ J. A. V A N D E R H E I D E , * J. F. W. T E R T O O L E N , § H. M. J. T H E E L E N t and C. Z E G E R S . ¢ (Received 1 April 1976)
A method is described for a routine production of sizeable quantities of iodine-123 for medical diagnosis. The iodine-123 is produced via a (p, 2n) reaction on enriched tellurium124 targets. Results are presented for relevant excitation functions. A new approach to target chemistry--comprising target preparation, separation of tellurium and carrier-free radioiodine, and target-material recovery--is presented. Irradiation techniques and chemical procedures are described in some detail.
INTRODUCTION Trm ~Dwa,rrAG~S of iodine-123 over iodine131 for some in vivo diagnostic p r o c e d u r e s - which may be completed within 24 hr or less--have now been widely recognized. The iodine-123 may be produced via a number of nuclear reactions involving various natural or enriched targets, various bombarding particles and bombarding energies from a few MeV to tens of MeW. (1'2" 3, 4, 5,6, 7) At the Eindhoven University of Technology a project was started to produce iodine-123 for local users on a routine scale with the university A V F cyclotron. A description of the cyclotron, the maximum energy of which is 30 MeV for protons, is given elsewhere. (s) In this study we have decided in favor of proton activation of tellurium. According to our own measurements and published results of Acerbi et al. (2) and Wolf et al.
