LAB/IN VITRO RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2016; 22: 4152-4158 DOI: 10.12659/MSM.897792
A Novel Method for Pathway Identification Based on Attractor and Crosstalk in Polyarticular Juvenile Idiopathic Arthritis
Received: 2016.01.26 Accepted: 2016.03.15 Published: 2016.11.02
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
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Yuanji Wang Shunhua Lin Changhui Li Yizhao Li Lei Chen Yingzhen Wang
1 Department of Orthopaedics, The People’s Hospital of Rizhao, Rizhao, Shandong, P.R. China 2 Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P.R. China
Yingzhen Wang, e-mail: [email protected] Departmental sources
Juvenile idiopathic arthritis (JIA) is one of the most common inflammatory disorders of unknown etiology. We introduced a novel method to identify dysregulated pathways associated with polyarticular JIA (pJIA). Gene expression profiling of 61 children with pJIA and 59 healthy controls were collected from E-GEOD-13849; 300 pathways were obtained from Kyoto Encyclopedia of Genes and Genomes (KEGG) database and 787,896 protein-protein interaction sets were gathered from the Retrieval of Interacting Genes. Attractor and crosstalk were designed to complement each other to increase the integrity of pathways assessment. Then, impact factor was used to assess the interactions inter-pathways, and RP-value was used to evaluate the comprehensive influential ability of attractors. There were seven attractors with p
A Novel Method for Pathway Identification Based on Attractor and Crosstalk in Polyarticular Juvenile Idiopathic Arthritis
Received: 2016.01.26 Accepted: 2016.03.15 Published: 2016.11.02
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
BCDEFG 1,2 BCDEFG 1,2 BCDEFG 1,2 CDEFG 1 ABCDEFG 1 ABCDEFG 2
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
MeSH Keywords:
Full-text PDF:
Yuanji Wang Shunhua Lin Changhui Li Yizhao Li Lei Chen Yingzhen Wang
1 Department of Orthopaedics, The People’s Hospital of Rizhao, Rizhao, Shandong, P.R. China 2 Department of Joint Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, P.R. China
Yingzhen Wang, e-mail: [email protected] Departmental sources
Juvenile idiopathic arthritis (JIA) is one of the most common inflammatory disorders of unknown etiology. We introduced a novel method to identify dysregulated pathways associated with polyarticular JIA (pJIA). Gene expression profiling of 61 children with pJIA and 59 healthy controls were collected from E-GEOD-13849; 300 pathways were obtained from Kyoto Encyclopedia of Genes and Genomes (KEGG) database and 787,896 protein-protein interaction sets were gathered from the Retrieval of Interacting Genes. Attractor and crosstalk were designed to complement each other to increase the integrity of pathways assessment. Then, impact factor was used to assess the interactions inter-pathways, and RP-value was used to evaluate the comprehensive influential ability of attractors. There were seven attractors with p
