HHS Public Access Author manuscript Author Manuscript
Br J Haematol. Author manuscript; available in PMC 2017 November 01. Published in final edited form as: Br J Haematol. 2016 November ; 175(4): 724–732. doi:10.1111/bjh.14298.
A rapid, inexpensive and disposable point-of-care blood test for sickle cell disease using novel, highly specific monoclonal antibodies Charles T. Quinn, MD, MS1, Mary C. Paniagua, MA1, Robert K. DiNello, PhD2, Anand Panchal, BS2, and Mark Geisberg, PhD.2
Author Manuscript
1Cincinnati 2Silver
Children's Hospital Medical Center, Cincinnati, OH.
Lake Research Corporation, Azusa, CA.
Summary
Author Manuscript
Sickle cell disease (SCD) is a significant healthcare burden worldwide, but most affected individuals reside in low-resource areas where access to diagnostic testing may be limited. We developed and validated a rapid, inexpensive, disposable diagnostic test, the HemoTypeSC™, based on novel monoclonal antibodies (MAbs) that differentiate normal adult haemoglobin (Hb A), sickle haemoglobin (Hb S) and haemoglobin C (Hb C). In competitive enzyme-linked immunosorbent assays, each MAb bound only its target with
Br J Haematol. Author manuscript; available in PMC 2017 November 01. Published in final edited form as: Br J Haematol. 2016 November ; 175(4): 724–732. doi:10.1111/bjh.14298.
A rapid, inexpensive and disposable point-of-care blood test for sickle cell disease using novel, highly specific monoclonal antibodies Charles T. Quinn, MD, MS1, Mary C. Paniagua, MA1, Robert K. DiNello, PhD2, Anand Panchal, BS2, and Mark Geisberg, PhD.2
Author Manuscript
1Cincinnati 2Silver
Children's Hospital Medical Center, Cincinnati, OH.
Lake Research Corporation, Azusa, CA.
Summary
Author Manuscript
Sickle cell disease (SCD) is a significant healthcare burden worldwide, but most affected individuals reside in low-resource areas where access to diagnostic testing may be limited. We developed and validated a rapid, inexpensive, disposable diagnostic test, the HemoTypeSC™, based on novel monoclonal antibodies (MAbs) that differentiate normal adult haemoglobin (Hb A), sickle haemoglobin (Hb S) and haemoglobin C (Hb C). In competitive enzyme-linked immunosorbent assays, each MAb bound only its target with
