Feng et al. Exp Hematol Oncol (2016) 5:12 DOI 10.1186/s40164-016-0041-6
Experimental Hematology & Oncology Open Access
RESEARCH
A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes Gege Feng1,2, Robert Peter Gale3, Wen Cui4, Wenyu Cai4, Gang Huang5, Zefeng Xu1,2, Tiejun Qin1, Yue Zhang1,2, Bing Li1,2, Liwei Fang1, Hongli Zhang1, Lijuan Pan1, Naibo Hu1, Shiqiang Qu1, Jingya Wang2, Yajuan Cui2 and Zhijian Xiao1,2*
Abstract Background: Dys-megakaryopoiesis is defined as ≥10 % of dysplastic megakaryocytes in bone marrow smears by the World Health Organization. However, concordance rates for dysplastic megakaryocytes between different observers is low and, consequently, evaluation of dysmegakaryopoiesis is also often discordant. Results: We performed CD41 immune staining and proposed a systematic classification of dys-megakaryopoiesis on bone marrow films: (1) micro-megakaryocytes (
Experimental Hematology & Oncology Open Access
RESEARCH
A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes Gege Feng1,2, Robert Peter Gale3, Wen Cui4, Wenyu Cai4, Gang Huang5, Zefeng Xu1,2, Tiejun Qin1, Yue Zhang1,2, Bing Li1,2, Liwei Fang1, Hongli Zhang1, Lijuan Pan1, Naibo Hu1, Shiqiang Qu1, Jingya Wang2, Yajuan Cui2 and Zhijian Xiao1,2*
Abstract Background: Dys-megakaryopoiesis is defined as ≥10 % of dysplastic megakaryocytes in bone marrow smears by the World Health Organization. However, concordance rates for dysplastic megakaryocytes between different observers is low and, consequently, evaluation of dysmegakaryopoiesis is also often discordant. Results: We performed CD41 immune staining and proposed a systematic classification of dys-megakaryopoiesis on bone marrow films: (1) micro-megakaryocytes (
