Eur Child Adolesc Psychiatry (2016) 25:869–878 DOI 10.1007/s00787-015-0805-2
ORIGINAL CONTRIBUTION
Abnormalities of white matter integrity in the corpus callosum of adolescents with PTSD after childhood sexual abuse: a DTI study Mirjam A. W. Rinne‑Albers1 · Steven J. A. van der Werff2,3 · Marie‑José van Hoof1,3,4 · Natasja D. van Lang1 · Francien Lamers‑Winkelman5 · Serge A. Rombouts3,6,7 · Robert R. J. M. Vermeiren1,3,5 · Nic J. A. van der Wee2,3
Received: 6 April 2015 / Accepted: 28 November 2015 / Published online: 23 December 2015 © The Author(s) 2015. This article is published with open access at Springerlink.com
Abstract This study seeks to determine whether white matter integrity in the brain differs between adolescents with post-traumatic stress disorder (PTSD) due to childhood sexual abuse (CSA) and matched healthy adolescents and whether there is a relationship between white matter integrity and symptom severity in the patient group. Using 3T diffusion tensor imaging, we examined fractional anisotropy (FA) in a group of adolescents with CSA-related PTSD (n = 20) and matched healthy controls (n = 20), in a region of interest consisting of the bilateral uncinate fasciculus (UF), the genu, splenium and body of the corpus callosum (CC), and the bilateral cingulum. In addition, we performed an exploratory whole brain analysis. Trauma symptomatology was measured with the Trauma Symptom Checklist for Children (TSCC) to enable correlational
analyses between FA differences and trauma symptomatology. The PTSD group had significantly lower FA values in the genu, midbody and splenium of the CC in comparison with controls (p
ORIGINAL CONTRIBUTION
Abnormalities of white matter integrity in the corpus callosum of adolescents with PTSD after childhood sexual abuse: a DTI study Mirjam A. W. Rinne‑Albers1 · Steven J. A. van der Werff2,3 · Marie‑José van Hoof1,3,4 · Natasja D. van Lang1 · Francien Lamers‑Winkelman5 · Serge A. Rombouts3,6,7 · Robert R. J. M. Vermeiren1,3,5 · Nic J. A. van der Wee2,3
Received: 6 April 2015 / Accepted: 28 November 2015 / Published online: 23 December 2015 © The Author(s) 2015. This article is published with open access at Springerlink.com
Abstract This study seeks to determine whether white matter integrity in the brain differs between adolescents with post-traumatic stress disorder (PTSD) due to childhood sexual abuse (CSA) and matched healthy adolescents and whether there is a relationship between white matter integrity and symptom severity in the patient group. Using 3T diffusion tensor imaging, we examined fractional anisotropy (FA) in a group of adolescents with CSA-related PTSD (n = 20) and matched healthy controls (n = 20), in a region of interest consisting of the bilateral uncinate fasciculus (UF), the genu, splenium and body of the corpus callosum (CC), and the bilateral cingulum. In addition, we performed an exploratory whole brain analysis. Trauma symptomatology was measured with the Trauma Symptom Checklist for Children (TSCC) to enable correlational
analyses between FA differences and trauma symptomatology. The PTSD group had significantly lower FA values in the genu, midbody and splenium of the CC in comparison with controls (p
