OS – Opening Session
OS – OPENING SESSION Saturday 30 August 17:30–20:00, Grand Auditorium
OS-7 – Opening Lecture 2 A neandertal perspective on human origins
OS-6 – Opening Lecture 1 Molecular and neural architecture of social behavior circuits in the mouse C. Dulac Harvard University, Cambridge, United States Our group is interested in the cellular and molecular architecture of neural circuits underlying instinctive social behaviors in the mouse. We will describe our recent advances in uncovering the identity of sensory neurons detecting social cues, and of command circuits associated with specific social responses in males and females.
FEBS Journal 281 (Suppl. 1) (2014) 1 ª 2014 The Authors. FEBS Journal ª 2014 FEBS
S. P€a€abo Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany We have sequenced the genomes of a Neandertal and a Denisovan (an Asian relative of Neandertals) to high quality. These two extinct human forms are the closest evolutionary relatives of all present-day humans. Analyses of these genomes in conjunction with present-day genomes show that both groups have mixed with modern humans after they spread out of Africa. As a consequence, up to 2.0% of the genomes of people living outside Africa derive from Neandertals while an additional ~4.8% of the genomes of people now living in Melanesia derive from Denisovans. The Neandertal and Denisova genomes allow the identification of novel genomic features that appeared in present-day humans since their divergence from a common ancestor with their closest extinct relatives. I will describe a preliminary analysis of these features and will illustrate how such genes can be functionally analyzed. I will also discuss what has so far been gleaned about the functional consequences of the Neandertal genetic contributions to present-day humans.