Horm Mol Biol Clin Invest 2014; 20(3): 71–72
Letter to the Editor Nikola Getoff*
Acute mental feelings and professional stress are controlling health. Mechanism and role of hormones and “solvated electrons” (e–aq ) Keywords: hormones; mental feelings; professional stress; solvated electrons. DOI 10.1515/hmbci-2014-0031 Received October 20, 2014; accepted November 5, 2014
Introduction It was already known by the ancients Greeks and Romans that the psychic balance of a person is a guarantor for health and happiness. Feelings, thoughts and tragic events can strongly influence health, and numerous studies in modern medicine have proved this phenomenon. Many physical diseases cannot simply be explained by infections and biochemical reactions in the organism. Thus, psychical influences, such as fear, sadness, fury, etc., play an essential role. It has been proven that long-lasting nervous professional stress leads – via the hypophysis and pineal gland – to disturbances in the brain, as well as in the gland-systems (generation of hormones in organism), which leads to a chain of reactions. These processes have consequences for all important body functions and are, within certain limits, very natural phenomena. However, a prolonged and frequently occurring overexcitement of the vegetative nervous system effects disorders in the organism, such as weakness of the immune system and may consequently provoke illnesses. According to the classification of psychic stress, we can distinguish between: (i) passive feelings (sadness, professional stress, fear, despair, etc.) and (ii) aggressive motions (e.g., anger, annoyance, trouble and impatience). The feelings included in the first group, affect the *Corresponding author: Prof. Dr. Nikola Getoff, Faculty of Life Sciences, Section of Radiation Biology, Department of Nutritional Sciences, The University of Vienna, A-1090 Vienna, Althanstr. 14, Austria, E-mail: [email protected]
hypocampus region of the brain, specifically the hypophysis, which produces a number of hormones, such as somatotropin, corticotropin, thyreotropin, etc., as well as the adrenal glands, where the hormones adrenalin and cortisone are generated. If the passive feelings occur frequently and are long-lasting, the defense mechanisms of the organism can result in disorders. This can lead to reduced resistance against infections, tumors, etc., and can also result in arthritis and muscular atrophy – illnesses where the body attacks itself. On the contrary the aggressive motions affect another area of the brain, which activates the suprarenal gland system. As a sequence of this, an overproduction of adrenalin takes place, which leads to an acceleration of the heart rate, increase of the blood pressure and to a higher content of fatty-acids in the blood. Therefore, long-lasting psychic stress can lead to heart-illness and apoplexy.
Reaction mechanisms It is well known that most of the organism’s biological functions are permanently activated and controlled by various types of hormones. It was experimentally proven that hormones do not act per se, but emit “solvated elec– ), which adopt the specific frequency of the trons” (eaq “mother molecule” [1]. As a sequence of the electron emission from each hormone, simultaneously free radical is – generated. The emitted eaq and the resulting free radical are responsible for the hormone effect. Both types of – species, eaq and the free radical, together with the resulting metabolites, are managing the well-known biological hormonal effects [2, 3]. – The existence of eaq was first observed through the conversion of aqueous CO2 into simple organic substances, under the influence of ionizing radiation [4] and UV-light – [4, 5]. The maximum of the eaq absorption spectrum at room temperature was determined at λ = 720 nm by the pulse radiolysis method [6], whereas at 77°K the formed
72 Getoff: Acute mental feelings and professional stress are controlling health trapped electrons (etp– ) have an absorption maximum at – λ = 575 nm, as measured by the ESR-technique [7]. The eaq represents a thermalized electron with energy, E ≤ 10 eV (1 eV = 23 kcal/mol), and is embedded in a solvation shell – with arranged positive dipoles of water molecules. eaq is the basic form of the H-atom, both of which, according to the pH of the aqueous medium, is mutually transformable.
– + eaq + H aq → H;
k=2.3×10 10 L/mol/s[ 8 ]
– – H + OH aq → eaq ;
k=2.2×10 7 L/mol/s[ 8 ]
Eq. (1) Eq. (2)
– At the same time of eaq emission, the hormones also – react with eaq (rate constants: k≅5 × 109–3 × 1010 L/mol/s), resulting an additional formation of free radicals [2, 3]. Beyond that, electron transfer also takes place from hormone-electron-donor to another hormone as well as to neighboring biological molecules [9], the letter of which is the mechanism of electron transfer within the DNAsystem [10]. Simultaneously with these processes, the – main transfer of eaq proceeds via the brain. Based on the specific frequence of the emitted electrons the receiving cells in the brain can immediately identify the electrons origin and act correspondently. This process enables a precise communication between hormones as well as between hormones and other biological systems in the organism [1]. Therefore the brain acts as the main center of communication. As a consequence to strong passive or aggressive motions, an over production of a given hormone is induced, which immediately leads to overproduction of – eaq , with the corresponding specific frequency. Via the brain, this leads to a disharmony of the hormone-household in the organism. As a consequence of these complex processes, several undesirable biological reactions are induced, which can cause, amongst others weakness of the immune system, resulting various illnesses.
It can be concluded that frequently occurring, longlasting, strong passive or aggressive feelings can cause biological wasting and activate hormonal glands. Subsequently, an overproduction of hormones is triggered, – which for their part cause an overproduction of eaq with specific frequency. The resulting biological situation affects a disorder of the hormonal balance in the organism, leading to weakness of the immune system and eventually to illnesses.
References 1. Getoff N. UV-radiation induced electron emission by hormones. Hypothesis for specific communication mechanisms. Radiat Phys Chem 2009;78:945–50. 2. Getoff N. Hormones: emission and regeneration. Nachrichten aus der Chemie 2011;59:1050–3, in German. 3. Getoff N. Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action. Horm Mol Biol Clin Invest 2012;12:363–75. 4. Getoff N, Scholes G, Weiss J. Reduction of carbon dioxide in aqueous solution under the influence of radiation. Tetrahedron Lett 1960;19:17–23. 5. Getoff N. Reduction of carbon dioxide in aqueous solution under the influence of UV-light (in German). Z f Naturforsch 1962;17b:87–90. 6. Hart EJ, Boag JW. Absorption spectrum of the hydrated electron in water and in aqueous solutions. J Am Chem Soc 1962;84:4090–5. 7. Schulte-Frohlinde D, Eiben K, Solvated electrons in frozen solutions (in German). Z f Naturforsch 1962;17a:445–6. 8. Buxton GV, Greenstock CL, Helman WPh, Ross AB. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution. Phys Chem Ref Data 1988;17:513–886. 9. Getoff N, Schittl H, Hartmann J, Gerschpacher M, Ying SH, Danielova I, Huber JC. Mutual interaction of 17β-estradiol and progesterone: Electron emission. Free radical effect studied by experiments in vitro. In Vivo 2010;24:535–42. 10. Getoff N. Fundamental biological importance of solvated electrons in humans. Horm Mol Biol Clin Invest 2013;16;125–8.
Copyright of Hormone Molecular Biology & Clinical Investigation is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Letter to the Editor Nikola Getoff*
Acute mental feelings and professional stress are controlling health. Mechanism and role of hormones and “solvated electrons” (e–aq ) Keywords: hormones; mental feelings; professional stress; solvated electrons. DOI 10.1515/hmbci-2014-0031 Received October 20, 2014; accepted November 5, 2014
Introduction It was already known by the ancients Greeks and Romans that the psychic balance of a person is a guarantor for health and happiness. Feelings, thoughts and tragic events can strongly influence health, and numerous studies in modern medicine have proved this phenomenon. Many physical diseases cannot simply be explained by infections and biochemical reactions in the organism. Thus, psychical influences, such as fear, sadness, fury, etc., play an essential role. It has been proven that long-lasting nervous professional stress leads – via the hypophysis and pineal gland – to disturbances in the brain, as well as in the gland-systems (generation of hormones in organism), which leads to a chain of reactions. These processes have consequences for all important body functions and are, within certain limits, very natural phenomena. However, a prolonged and frequently occurring overexcitement of the vegetative nervous system effects disorders in the organism, such as weakness of the immune system and may consequently provoke illnesses. According to the classification of psychic stress, we can distinguish between: (i) passive feelings (sadness, professional stress, fear, despair, etc.) and (ii) aggressive motions (e.g., anger, annoyance, trouble and impatience). The feelings included in the first group, affect the *Corresponding author: Prof. Dr. Nikola Getoff, Faculty of Life Sciences, Section of Radiation Biology, Department of Nutritional Sciences, The University of Vienna, A-1090 Vienna, Althanstr. 14, Austria, E-mail: [email protected]
hypocampus region of the brain, specifically the hypophysis, which produces a number of hormones, such as somatotropin, corticotropin, thyreotropin, etc., as well as the adrenal glands, where the hormones adrenalin and cortisone are generated. If the passive feelings occur frequently and are long-lasting, the defense mechanisms of the organism can result in disorders. This can lead to reduced resistance against infections, tumors, etc., and can also result in arthritis and muscular atrophy – illnesses where the body attacks itself. On the contrary the aggressive motions affect another area of the brain, which activates the suprarenal gland system. As a sequence of this, an overproduction of adrenalin takes place, which leads to an acceleration of the heart rate, increase of the blood pressure and to a higher content of fatty-acids in the blood. Therefore, long-lasting psychic stress can lead to heart-illness and apoplexy.
Reaction mechanisms It is well known that most of the organism’s biological functions are permanently activated and controlled by various types of hormones. It was experimentally proven that hormones do not act per se, but emit “solvated elec– ), which adopt the specific frequency of the trons” (eaq “mother molecule” [1]. As a sequence of the electron emission from each hormone, simultaneously free radical is – generated. The emitted eaq and the resulting free radical are responsible for the hormone effect. Both types of – species, eaq and the free radical, together with the resulting metabolites, are managing the well-known biological hormonal effects [2, 3]. – The existence of eaq was first observed through the conversion of aqueous CO2 into simple organic substances, under the influence of ionizing radiation [4] and UV-light – [4, 5]. The maximum of the eaq absorption spectrum at room temperature was determined at λ = 720 nm by the pulse radiolysis method [6], whereas at 77°K the formed
72 Getoff: Acute mental feelings and professional stress are controlling health trapped electrons (etp– ) have an absorption maximum at – λ = 575 nm, as measured by the ESR-technique [7]. The eaq represents a thermalized electron with energy, E ≤ 10 eV (1 eV = 23 kcal/mol), and is embedded in a solvation shell – with arranged positive dipoles of water molecules. eaq is the basic form of the H-atom, both of which, according to the pH of the aqueous medium, is mutually transformable.
– + eaq + H aq → H;
k=2.3×10 10 L/mol/s[ 8 ]
– – H + OH aq → eaq ;
k=2.2×10 7 L/mol/s[ 8 ]
Eq. (1) Eq. (2)
– At the same time of eaq emission, the hormones also – react with eaq (rate constants: k≅5 × 109–3 × 1010 L/mol/s), resulting an additional formation of free radicals [2, 3]. Beyond that, electron transfer also takes place from hormone-electron-donor to another hormone as well as to neighboring biological molecules [9], the letter of which is the mechanism of electron transfer within the DNAsystem [10]. Simultaneously with these processes, the – main transfer of eaq proceeds via the brain. Based on the specific frequence of the emitted electrons the receiving cells in the brain can immediately identify the electrons origin and act correspondently. This process enables a precise communication between hormones as well as between hormones and other biological systems in the organism [1]. Therefore the brain acts as the main center of communication. As a consequence to strong passive or aggressive motions, an over production of a given hormone is induced, which immediately leads to overproduction of – eaq , with the corresponding specific frequency. Via the brain, this leads to a disharmony of the hormone-household in the organism. As a consequence of these complex processes, several undesirable biological reactions are induced, which can cause, amongst others weakness of the immune system, resulting various illnesses.
It can be concluded that frequently occurring, longlasting, strong passive or aggressive feelings can cause biological wasting and activate hormonal glands. Subsequently, an overproduction of hormones is triggered, – which for their part cause an overproduction of eaq with specific frequency. The resulting biological situation affects a disorder of the hormonal balance in the organism, leading to weakness of the immune system and eventually to illnesses.
References 1. Getoff N. UV-radiation induced electron emission by hormones. Hypothesis for specific communication mechanisms. Radiat Phys Chem 2009;78:945–50. 2. Getoff N. Hormones: emission and regeneration. Nachrichten aus der Chemie 2011;59:1050–3, in German. 3. Getoff N. Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action. Horm Mol Biol Clin Invest 2012;12:363–75. 4. Getoff N, Scholes G, Weiss J. Reduction of carbon dioxide in aqueous solution under the influence of radiation. Tetrahedron Lett 1960;19:17–23. 5. Getoff N. Reduction of carbon dioxide in aqueous solution under the influence of UV-light (in German). Z f Naturforsch 1962;17b:87–90. 6. Hart EJ, Boag JW. Absorption spectrum of the hydrated electron in water and in aqueous solutions. J Am Chem Soc 1962;84:4090–5. 7. Schulte-Frohlinde D, Eiben K, Solvated electrons in frozen solutions (in German). Z f Naturforsch 1962;17a:445–6. 8. Buxton GV, Greenstock CL, Helman WPh, Ross AB. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution. Phys Chem Ref Data 1988;17:513–886. 9. Getoff N, Schittl H, Hartmann J, Gerschpacher M, Ying SH, Danielova I, Huber JC. Mutual interaction of 17β-estradiol and progesterone: Electron emission. Free radical effect studied by experiments in vitro. In Vivo 2010;24:535–42. 10. Getoff N. Fundamental biological importance of solvated electrons in humans. Horm Mol Biol Clin Invest 2013;16;125–8.
Copyright of Hormone Molecular Biology & Clinical Investigation is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
