896
Addition of Long-Chain Polyunsaturated Fatty Acids to Formula for Very Low Birth Weight Infants 1 M.T. Clandinina, b,c, *, M.L. Garg a,b, A. Parrott a,b, J. Van Aerde a,d, A. Hervada e and E. Lien e aNutrition and Metabolism Research Group, bDepartment of Foods and Nutrition, CDepartment of Medicine, dDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2C2 and eWyeth-Ayerst Research, Radnor, Pennsylvania, 19101-1245
Thirty-four premature infants who were appropriate for gestational age and weighing less than 1500 g at birth were fed "preemie" SMA-24 formula, "preemie" SMA-24 for~ mula manufactured to contain C20 and C22 r and w3 fatty acids (LCPF_~SMA), or expressed milk (EBM). Blood samples were drawn from a small arm vein during the first week of life and after 28 days of feeding. The fatty acid content of plasma phospholipids was determined. Infants fed SMA-24 had a high content of 18:2w6 in plasma phospholipids. Feeding LCPE-SMA normalized plasma phospholipid levels of Cz0 and C2~ o~6 and co3 fatty acids to be similar to levels of C~0 and Cz2 w6 and ~03 fatty acids found in infants fed EBM, and significantly higher than characteristic levels for infants fed SMA-24. Feeding LCPF~SMA or EBM results in a balanced incorporation of Cz0 and C22 c06 and w3 fatty acids into phospholipids derived from the liver or perhaps the small intestine. Lipids 27, 896-900 (1992). Metabolism of long-chain polyunsaturated fatty acids derived from 18:2(o6 and 18:3co3 by chain elongation
Addition of Long-Chain Polyunsaturated Fatty Acids to Formula for Very Low Birth Weight Infants 1 M.T. Clandinina, b,c, *, M.L. Garg a,b, A. Parrott a,b, J. Van Aerde a,d, A. Hervada e and E. Lien e aNutrition and Metabolism Research Group, bDepartment of Foods and Nutrition, CDepartment of Medicine, dDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2C2 and eWyeth-Ayerst Research, Radnor, Pennsylvania, 19101-1245
Thirty-four premature infants who were appropriate for gestational age and weighing less than 1500 g at birth were fed "preemie" SMA-24 formula, "preemie" SMA-24 for~ mula manufactured to contain C20 and C22 r and w3 fatty acids (LCPF_~SMA), or expressed milk (EBM). Blood samples were drawn from a small arm vein during the first week of life and after 28 days of feeding. The fatty acid content of plasma phospholipids was determined. Infants fed SMA-24 had a high content of 18:2w6 in plasma phospholipids. Feeding LCPE-SMA normalized plasma phospholipid levels of Cz0 and C2~ o~6 and co3 fatty acids to be similar to levels of C~0 and Cz2 w6 and ~03 fatty acids found in infants fed EBM, and significantly higher than characteristic levels for infants fed SMA-24. Feeding LCPF~SMA or EBM results in a balanced incorporation of Cz0 and C22 c06 and w3 fatty acids into phospholipids derived from the liver or perhaps the small intestine. Lipids 27, 896-900 (1992). Metabolism of long-chain polyunsaturated fatty acids derived from 18:2(o6 and 18:3co3 by chain elongation
