Accepted Article
Article Type: Regular Article
Adolescents and young adults with type 1 diabetes display a high prevalence of endothelial dysfunction
A E Scaramuzza1, F Redaelli2, E Giani2, M Macedoni2, V Giudici2, A Gazzarri2, A Bosetti1, L De Angelis2, G V Zuccotti2.
(1) Department of Pediatrics, Azienda Ospedaliera, University of Milano, “Ospedale Luigi Sacco”, via G.B. Grassi 74, 20157 Milano, Italy (2) Department of Pediatrics, University of Milano, Ospedale dei Bambini V. Buzzi, Via Castelvetro 32, 20154 Milano, Italy
Running head: Endothelial dysfunction in type 1 diabetes
Corresponding author: Andrea E Scaramuzza Clinica Pediatrica
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/apa.12877 This article is protected by copyright. All rights reserved.
Accepted Article
Azienda Ospedaliera, University of Milan, “Ospedale Luigi Sacco” Via G.B. Grassi 74 - 20157 Milan, Italy Tel.: +39 02 39042791 / Fax: +39 02 39042254 E-mail: [email protected]
Abstract Aim: Little is known about endothelial function in adolescents with type 1 diabetes and we evaluated endothelial dysfunction, using reactive hyperaemia peripheral arterial tonometry (RHPAT). Methods: This prospective, observational, one-year study, focused on 73 adolescents with type 1 diabetes, using multiple daily injections or continuous subcutaneous insulin infusion. The subjects were assessed using RH-PAT, body mass index, blood pressure, fasting lipid profile, glycated haemoglobin, insulin requirements and hours of physical exercise per week. Results: Endothelial dysfunction was observed in 56 patients (76.7%), with lower mean RH-PAT scores (1.26±0.22 vs. 2.24±0.48, p95th percentile or 1.67 meaning normal endothelial function and a score of
Article Type: Regular Article
Adolescents and young adults with type 1 diabetes display a high prevalence of endothelial dysfunction
A E Scaramuzza1, F Redaelli2, E Giani2, M Macedoni2, V Giudici2, A Gazzarri2, A Bosetti1, L De Angelis2, G V Zuccotti2.
(1) Department of Pediatrics, Azienda Ospedaliera, University of Milano, “Ospedale Luigi Sacco”, via G.B. Grassi 74, 20157 Milano, Italy (2) Department of Pediatrics, University of Milano, Ospedale dei Bambini V. Buzzi, Via Castelvetro 32, 20154 Milano, Italy
Running head: Endothelial dysfunction in type 1 diabetes
Corresponding author: Andrea E Scaramuzza Clinica Pediatrica
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/apa.12877 This article is protected by copyright. All rights reserved.
Accepted Article
Azienda Ospedaliera, University of Milan, “Ospedale Luigi Sacco” Via G.B. Grassi 74 - 20157 Milan, Italy Tel.: +39 02 39042791 / Fax: +39 02 39042254 E-mail: [email protected]
Abstract Aim: Little is known about endothelial function in adolescents with type 1 diabetes and we evaluated endothelial dysfunction, using reactive hyperaemia peripheral arterial tonometry (RHPAT). Methods: This prospective, observational, one-year study, focused on 73 adolescents with type 1 diabetes, using multiple daily injections or continuous subcutaneous insulin infusion. The subjects were assessed using RH-PAT, body mass index, blood pressure, fasting lipid profile, glycated haemoglobin, insulin requirements and hours of physical exercise per week. Results: Endothelial dysfunction was observed in 56 patients (76.7%), with lower mean RH-PAT scores (1.26±0.22 vs. 2.24±0.48, p95th percentile or 1.67 meaning normal endothelial function and a score of
