Author Manuscript Published OnlineFirst on April 30, 2015; DOI: 10.1158/1940-6207.CAPR-15-0061 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.
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Adulthood weight change and risk of colorectal cancer in the Nurses’ Health Study and Health Professionals Follow-up Study Mingyang Song, Frank B. Hu, Donna Spiegelman, Andrew T. Chan, Kana Wu, Shuji Ogino, Charles S. Fuchs, Walter C. Willett, Edward L. Giovannucci Departments of Nutrition (MS, FBH, DS, KW, WCW, and ELG), Epidemiology (MS, FBH, DS, SO, WCW, and ELG), Biostatistics (DS), and Global Health and Population (DS), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine, Department of Medicine, Harvard Medical School (FBH, ATC, SO, CSF, WCW, and ELG); Division of Gastroenterology, Massachusetts General Hospital (ATC); Department of Medical Oncology, Dana-Farber Cancer Institute (SO and CSF); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (SO). Running title: Adulthood weight change and colorectal cancer Keywords: weight gain, weight loss, obesity, colorectal cancer
Financial support: This work was supported by the National Institutes of Health (UM1 CA186107, P01 CA87969, UM1 CA167552, 1U54CA155626, and K24 DK098311). Corresponding author: Dr. Edward L. Giovannucci, Department of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA, 02115. Tel: +01-617-4324648, Fax: +01-617-432-2435, Email: [email protected] Conflict of interest: The authors have no conflicts of interest to disclose. Word count: 3,032 Total Number of Tables: 5
Downloaded from cancerpreventionresearch.aacrjournals.org on May 2, 2015. © 2015 American Association for Cancer Research.
Author Manuscript Published OnlineFirst on April 30, 2015; DOI: 10.1158/1940-6207.CAPR-15-0061 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.
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ABSTRACT We investigated the association between adulthood weight change and CRC risk in a prospective study with 24-34 years of follow-up among 90,988 women and 46,679 men. The primary exposures included weight change from early adulthood (age=18 for women, 21 for men) to baseline enrollment (median age=43 for women, 52 for men), and from baseline to present. In the secondary analyses, we also assessed 4-year weight change during follow-up, and during premenopausal (from age 18 to menopause) and postmenopausal (from menopause to present) periods in women. Compared to men maintaining their weight from age 21 to baseline, those who gained 20kg or more were at a higher risk of CRC (relative risk [RR], 1.64; 95% confidence interval [CI], 1.15-2.35, P for trend
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Adulthood weight change and risk of colorectal cancer in the Nurses’ Health Study and Health Professionals Follow-up Study Mingyang Song, Frank B. Hu, Donna Spiegelman, Andrew T. Chan, Kana Wu, Shuji Ogino, Charles S. Fuchs, Walter C. Willett, Edward L. Giovannucci Departments of Nutrition (MS, FBH, DS, KW, WCW, and ELG), Epidemiology (MS, FBH, DS, SO, WCW, and ELG), Biostatistics (DS), and Global Health and Population (DS), Harvard T.H. Chan School of Public Health; Channing Division of Network Medicine, Department of Medicine, Harvard Medical School (FBH, ATC, SO, CSF, WCW, and ELG); Division of Gastroenterology, Massachusetts General Hospital (ATC); Department of Medical Oncology, Dana-Farber Cancer Institute (SO and CSF); Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (SO). Running title: Adulthood weight change and colorectal cancer Keywords: weight gain, weight loss, obesity, colorectal cancer
Financial support: This work was supported by the National Institutes of Health (UM1 CA186107, P01 CA87969, UM1 CA167552, 1U54CA155626, and K24 DK098311). Corresponding author: Dr. Edward L. Giovannucci, Department of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA, 02115. Tel: +01-617-4324648, Fax: +01-617-432-2435, Email: [email protected] Conflict of interest: The authors have no conflicts of interest to disclose. Word count: 3,032 Total Number of Tables: 5
Downloaded from cancerpreventionresearch.aacrjournals.org on May 2, 2015. © 2015 American Association for Cancer Research.
Author Manuscript Published OnlineFirst on April 30, 2015; DOI: 10.1158/1940-6207.CAPR-15-0061 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.
2
ABSTRACT We investigated the association between adulthood weight change and CRC risk in a prospective study with 24-34 years of follow-up among 90,988 women and 46,679 men. The primary exposures included weight change from early adulthood (age=18 for women, 21 for men) to baseline enrollment (median age=43 for women, 52 for men), and from baseline to present. In the secondary analyses, we also assessed 4-year weight change during follow-up, and during premenopausal (from age 18 to menopause) and postmenopausal (from menopause to present) periods in women. Compared to men maintaining their weight from age 21 to baseline, those who gained 20kg or more were at a higher risk of CRC (relative risk [RR], 1.64; 95% confidence interval [CI], 1.15-2.35, P for trend
