Open Access
Research
Adverse childhood or adult experiences and risk of bilateral oophorectomy: a population-based case–control study Liliana Gazzuola Rocca,1 Carin Y Smith,2 Brandon R Grossardt,2 Stephanie S Faubion,3,4 Lynne T Shuster,4 Elizabeth A Stewart,3,5,6 Walter A Rocca1,7
To cite: Gazzuola Rocca L, Smith CY, Grossardt BR, et al. Adverse childhood or adult experiences and risk of bilateral oophorectomy: a population-based case– control study. BMJ Open 2017;7:e016045. doi:10.1136/ bmjopen-2017-016045 ►► Prepublication history and additional material are available. To view these files, please visit the journal online (http://dx.doi.org/ 10.1136/ bmjopen-2017-016045)
Received 23 January 2017 Revised 28 February 2017 Accepted 6 April 2017
ABSTRACT
Objectives Bilateral oophorectomy has commonly been performed in conjunction with hysterectomy even in women without a clear ovarian indication; however, oophorectomy may have long-term deleterious consequences. To better understand this surgical practice from the woman’s perspective, we studied the possible association of adverse childhood or adult experiences with the subsequent occurrence of bilateral oophorectomy. Design Population-based case–control study. Setting Olmsted County, Minnesota (USA). Participants From an established population-based cohort study, we sampled 128 women who underwent bilateral oophorectomy before age 46 years for a noncancerous condition in 1988–2007 (cases) and 128 agematched controls (±1 year). Methods Information about adverse experiences was abstracted from the medical records dating back to age 15 years or earlier archived in the Rochester Epidemiology Project (REP) records-linkage system. Adverse childhood experiences were summarised using the Adverse Childhood Experience (ACE) score. Results We observed an association of bilateral oophorectomy performed before age 46 years with verbal or emotional abuse, physical abuse, any abuse, substance abuse in the household, and with an ACE score ≥1 experienced before age 19 years (OR=3.23; 95% CI 1.73 to 6.02; p
Research
Adverse childhood or adult experiences and risk of bilateral oophorectomy: a population-based case–control study Liliana Gazzuola Rocca,1 Carin Y Smith,2 Brandon R Grossardt,2 Stephanie S Faubion,3,4 Lynne T Shuster,4 Elizabeth A Stewart,3,5,6 Walter A Rocca1,7
To cite: Gazzuola Rocca L, Smith CY, Grossardt BR, et al. Adverse childhood or adult experiences and risk of bilateral oophorectomy: a population-based case– control study. BMJ Open 2017;7:e016045. doi:10.1136/ bmjopen-2017-016045 ►► Prepublication history and additional material are available. To view these files, please visit the journal online (http://dx.doi.org/ 10.1136/ bmjopen-2017-016045)
Received 23 January 2017 Revised 28 February 2017 Accepted 6 April 2017
ABSTRACT
Objectives Bilateral oophorectomy has commonly been performed in conjunction with hysterectomy even in women without a clear ovarian indication; however, oophorectomy may have long-term deleterious consequences. To better understand this surgical practice from the woman’s perspective, we studied the possible association of adverse childhood or adult experiences with the subsequent occurrence of bilateral oophorectomy. Design Population-based case–control study. Setting Olmsted County, Minnesota (USA). Participants From an established population-based cohort study, we sampled 128 women who underwent bilateral oophorectomy before age 46 years for a noncancerous condition in 1988–2007 (cases) and 128 agematched controls (±1 year). Methods Information about adverse experiences was abstracted from the medical records dating back to age 15 years or earlier archived in the Rochester Epidemiology Project (REP) records-linkage system. Adverse childhood experiences were summarised using the Adverse Childhood Experience (ACE) score. Results We observed an association of bilateral oophorectomy performed before age 46 years with verbal or emotional abuse, physical abuse, any abuse, substance abuse in the household, and with an ACE score ≥1 experienced before age 19 years (OR=3.23; 95% CI 1.73 to 6.02; p
