LETTER TO THE EDITOR Allergic and anaphylactic reactions to methylene-blue-treated plasma in Catalonia in the period 2008-2013 Eduardo Muñiz-Diaz, Lluis Puig Blood and Tissue Bank, Barcelona, Spain
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France), since 1992 more than four million units of plasma have been transfused worldwide (Spain since 1999, Greece since 2000, Italy and UK since 2002, Belgium since 2004, Russia since 2006, Austria since 2007, France and Poland since 2008). In Spain nearly 1.4 million units have been virus-inactivated since 1997 with no reported serious adverse events. Our analysis of the haemovigilance data from the Catalonian region of Spain for the period 2008-2013 revealed that total and severe allergic reactions not only did not increase (Figure 1 and Table I), but rather, total reactions tended to decrease (Figure 1). The trend was statistically significant for red cell transfusions (p
iz i
Sr l
France), since 1992 more than four million units of plasma have been transfused worldwide (Spain since 1999, Greece since 2000, Italy and UK since 2002, Belgium since 2004, Russia since 2006, Austria since 2007, France and Poland since 2008). In Spain nearly 1.4 million units have been virus-inactivated since 1997 with no reported serious adverse events. Our analysis of the haemovigilance data from the Catalonian region of Spain for the period 2008-2013 revealed that total and severe allergic reactions not only did not increase (Figure 1 and Table I), but rather, total reactions tended to decrease (Figure 1). The trend was statistically significant for red cell transfusions (p
