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Received: 26 July 2016 Accepted: 18 September 2016 DOI: 10.1111/aji.12592
ORIGINAL ARTICLE
Alpha-7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation Kaori Yamada-Nomoto1 | Osamu Yoshino1 | Ikumi Akiyama2 | Akemi Ushijima1 | Yosuke Ono1 | Tomoko Shima1 | Akitoshi Nakashima1 | Shusaku Hayashi3 | Makoto Kadowaki3 | Yutaka Osuga2 | Shigeru Saito1 1 Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan 2
Abstract Objective: We investigated α-7 nAchR expression in human peritoneal macrophages
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
and examined whether activation of nAchR might be a new therapy for
3
Materials and methods: Human peritoneal fluid mononuclear cells (PFMC) were stim-
Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan Correspondence Shigeru Saito, Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan. Email: [email protected] Funding information This work was supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (number 26462479) and by The Smoking Research Foundation.
endometriosis. ulated with lipopolysaccharide (LPS) in the presence of α-7 nAChR agonists. In a murine endometriosis model, α-7 nAChR modulators were administered. Results: Human PFMC expressed α-7 nAChR at the mRNA and protein levels. Activation of α-7 nAChR with its agonists led to significant (P
Received: 26 July 2016 Accepted: 18 September 2016 DOI: 10.1111/aji.12592
ORIGINAL ARTICLE
Alpha-7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation Kaori Yamada-Nomoto1 | Osamu Yoshino1 | Ikumi Akiyama2 | Akemi Ushijima1 | Yosuke Ono1 | Tomoko Shima1 | Akitoshi Nakashima1 | Shusaku Hayashi3 | Makoto Kadowaki3 | Yutaka Osuga2 | Shigeru Saito1 1 Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan 2
Abstract Objective: We investigated α-7 nAchR expression in human peritoneal macrophages
Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
and examined whether activation of nAchR might be a new therapy for
3
Materials and methods: Human peritoneal fluid mononuclear cells (PFMC) were stim-
Division of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, Toyama, Japan Correspondence Shigeru Saito, Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan. Email: [email protected] Funding information This work was supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (number 26462479) and by The Smoking Research Foundation.
endometriosis. ulated with lipopolysaccharide (LPS) in the presence of α-7 nAChR agonists. In a murine endometriosis model, α-7 nAChR modulators were administered. Results: Human PFMC expressed α-7 nAChR at the mRNA and protein levels. Activation of α-7 nAChR with its agonists led to significant (P
