Proc. Nati. Acad. Sci. USA Vol. 88, pp. 6682-6686, August 1991 Immunology
Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor a-chain transgenic mice (clonal anergy/T-ceil activation)
MARCIA A. BLACKMAN*t, TERRI H. FINKELt, JOHN KAPPLER*§¶, JOHN CAMBIERt, AND PHILIPPA MARRACK*1§II *Howard Hughes Medical Institute at Denver; tDivision of Basic Sciences, Department of Pediatrics and $Division of Basic Immunology, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver; and §Department of Microbiology, Immunology, and Medicine, and 11Department of Biochemistry, Biophysics, and Genetics, University of Colorado Health Sciences Center, Denver, CO 80206
Contributed by Philippa Marrack, April 16, 1991
ABSTRACT
T-cell tolerance to the minor lymphocyte-
We have generated a Vp8.1' 3-chain transgenic mouse and genetically introduced the corresponding self-superantigen, Mls-1a, in order to study mechanisms of tolerance. Whereas virtually all T cells expressed V,98.1,
Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor a-chain transgenic mice (clonal anergy/T-ceil activation)
MARCIA A. BLACKMAN*t, TERRI H. FINKELt, JOHN KAPPLER*§¶, JOHN CAMBIERt, AND PHILIPPA MARRACK*1§II *Howard Hughes Medical Institute at Denver; tDivision of Basic Sciences, Department of Pediatrics and $Division of Basic Immunology, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver; and §Department of Microbiology, Immunology, and Medicine, and 11Department of Biochemistry, Biophysics, and Genetics, University of Colorado Health Sciences Center, Denver, CO 80206
Contributed by Philippa Marrack, April 16, 1991
ABSTRACT
T-cell tolerance to the minor lymphocyte-
We have generated a Vp8.1' 3-chain transgenic mouse and genetically introduced the corresponding self-superantigen, Mls-1a, in order to study mechanisms of tolerance. Whereas virtually all T cells expressed V,98.1,
