ONCOLOGY LETTERS 10: 1390-1396, 2015
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Alternatively activated macrophages are associated with metastasis and poor prognosis in prostate adenocarcinoma WENXUE HU, YUNJUAN QIAN, FENG YU, WEI LIU, YANHUA WU, XIAOWU FANG and WENKE HAO Guangdong Academy of Medical Science, Guangdong General Hospital, Guangdong Provincial Institute of Geriatrics, Guangzhou, Guangdong 510080, P.R. China Received August 19, 2014; Accepted May 7, 2015 DOI: 10.3892/ol.2015.3400 Abstract. Recent studies have revealed that alternatively activated macrophages (AAMs) are involved in tumor progression. However, the effect of AAMs on the metastasis of prostate cancer is poorly understood. In the present study, the prostate tissues of 42 patients with prostate adenocarcinoma (PCa) were used in the analysis of tumor associated macrophages (TAMs) and AAMs by immunofluorescence. The patients were followed up for 5 years. The associations of TAMs and AAMs with the clinicopathological features and outcome in these cases were evaluated. Immunofluorescent analysis indicated that the mean number of TAMs (CD68‑positive cells) in the prostate tissues of PCa patients with metastasis [45.29±7.25 cells/high‑power field (HPF)] was significantly higher compared with that of PCa patients without metastasis (33.57±5.25 cells/HPF; P
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Alternatively activated macrophages are associated with metastasis and poor prognosis in prostate adenocarcinoma WENXUE HU, YUNJUAN QIAN, FENG YU, WEI LIU, YANHUA WU, XIAOWU FANG and WENKE HAO Guangdong Academy of Medical Science, Guangdong General Hospital, Guangdong Provincial Institute of Geriatrics, Guangzhou, Guangdong 510080, P.R. China Received August 19, 2014; Accepted May 7, 2015 DOI: 10.3892/ol.2015.3400 Abstract. Recent studies have revealed that alternatively activated macrophages (AAMs) are involved in tumor progression. However, the effect of AAMs on the metastasis of prostate cancer is poorly understood. In the present study, the prostate tissues of 42 patients with prostate adenocarcinoma (PCa) were used in the analysis of tumor associated macrophages (TAMs) and AAMs by immunofluorescence. The patients were followed up for 5 years. The associations of TAMs and AAMs with the clinicopathological features and outcome in these cases were evaluated. Immunofluorescent analysis indicated that the mean number of TAMs (CD68‑positive cells) in the prostate tissues of PCa patients with metastasis [45.29±7.25 cells/high‑power field (HPF)] was significantly higher compared with that of PCa patients without metastasis (33.57±5.25 cells/HPF; P
