Food and Chemical Toxicology 80 (2015) 52–61

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Food and Chemical Toxicology j o u r n a l h o m e p a g e : w w w. e l s e v i e r. c o m / l o c a t e / f o o d c h e m t o x

An in vitro study on the cytotoxicity of bismuth oxychloride nanosheets in human HaCaT keratinocytes Xiaoya Gao, Xiaochao Zhang, Yawen Wang *, Yunfang Wang, Shiqi Peng, Caimei Fan ** College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China

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Article history: Received 20 January 2015 Accepted 23 February 2015 Available online 6 March 2015 Keywords: Bismuth oxychloride nanosheets HaCaT cells Cytotoxicity Cellular uptake Reactive oxygen species

A B S T R A C T

As an emerging nanomaterial, bismuth oxychloride (BiOCl) has attracted explosive interests in diverse areas. However, how it interfaces with biological systems, particularly its interaction with human cells and the resulting effects are completely unknown. In this paper, the cytotoxicity of BiOCl nanosheets (NSs) was investigated toward a human skin derived cell line (HaCaT). It was found that BiOCl-NSs had no cytotoxicity at low concentrations (