Research Original Investigation

Trends in Predialysis Anemia Care

Invited Commentary

Anemia in Chronic Kidney Disease Treating the Numbers, Not the Patients Daniel W. Coyne, MD

Epoetin alfa, the first erythropoiesis-stimulating agent (ESA), was approved in 1989 for the treatment of anemia in patients with chronic kidney disease (CKD). By 1991, in dialysis, there were no longer patients requiring regular transfusions Related article page 699 for severe anemia (eg, hemoglobin concentration,