0013-7227/78/1034-1494$02.00/0 Endocrinology Copyright © 1978 by The Endocrine Society
Vol. 103, No. 4 Printed in U.S.A.
Angiotensin II Concentration in Cerebrospinal Fluid after Intraventricular Injection of Angiotensinogen or Renin* IAN A. REIDf AND BARBARA MOFFAT Department of Physiology, University of California-San Francisco, San Francisco, California 94143 ABSTRACT. To determine if the brain enzyme which has renin-like activity in vitro can form angiotensin in vivo, angiotensin II concentration in cerebrospinal fluid (CSF) was measured before and at various intervals after injection of partially purified renin substrate (angiotensinogen) into the third cerebral ventricle of anesthetized dogs. The injection increased CSF angiotensinogen concentration 3-fold, but despite this, CSF angiotensin II concentration, which was undetectable (
Vol. 103, No. 4 Printed in U.S.A.
Angiotensin II Concentration in Cerebrospinal Fluid after Intraventricular Injection of Angiotensinogen or Renin* IAN A. REIDf AND BARBARA MOFFAT Department of Physiology, University of California-San Francisco, San Francisco, California 94143 ABSTRACT. To determine if the brain enzyme which has renin-like activity in vitro can form angiotensin in vivo, angiotensin II concentration in cerebrospinal fluid (CSF) was measured before and at various intervals after injection of partially purified renin substrate (angiotensinogen) into the third cerebral ventricle of anesthetized dogs. The injection increased CSF angiotensinogen concentration 3-fold, but despite this, CSF angiotensin II concentration, which was undetectable (
