ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, June 1990, 0066-4804/90/061107-05$02.00/0 Copyright © 1990, American Society for Microbiology
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Vol. 34, No. 6
1107-1111
Antibacterial Activity of Lomefloxacin in a Pharmacokinetic In Vitro Model CORNELIA RUSTIGE AND BERND WIEDEMANN* Pharmazeutische Mikrobiologie der Universitat Bonn, An der Immenburg 4, 5300 Bonn, Federal Republic of Germany Received 26 October 1989/Accepted 7 March 1990
An in vitro model simulating two-compartment pharmacokinetics was used to study the antibacterial activity of lomefloxacin after single oral doses of 200 and 400 mg. Lomefloxacin produced reliable bactericidal activity against gram-negative aerobic bacteria and staphylococci. Bacterial strains for which MICs were
p.
Vol. 34, No. 6
1107-1111
Antibacterial Activity of Lomefloxacin in a Pharmacokinetic In Vitro Model CORNELIA RUSTIGE AND BERND WIEDEMANN* Pharmazeutische Mikrobiologie der Universitat Bonn, An der Immenburg 4, 5300 Bonn, Federal Republic of Germany Received 26 October 1989/Accepted 7 March 1990
An in vitro model simulating two-compartment pharmacokinetics was used to study the antibacterial activity of lomefloxacin after single oral doses of 200 and 400 mg. Lomefloxacin produced reliable bactericidal activity against gram-negative aerobic bacteria and staphylococci. Bacterial strains for which MICs were
