Journal of Autoimmunity

(1992) 5,242-249

Antibodies against Polypeptides of Purified Epstein-Barr Virus in Sera from Patients with Connective Tissue Diseases

Jean Ngou,*t Hubert Graafland? and Michel Segondy* *INSERM

U 249 and TCentre de Transfusion

Sanguine,

Montpellier,

France

(Received 28 May 1991 and accepted 13 November 1991)

Antibodies to Epstein-Barr virus (EBV) were investigated in patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) by immunoblotting using purified virus. Compared with sera from Epstein-Barr virus seropositive healthy individuals who served as control, sera from patients less frequently recognized several polypeptides. In particular, a 100 ltDa envelope polypeptide was recognized by 92% of healthy subjects and only 11% of patients (P

Antibodies against polypeptides of purified Epstein-Barr virus in sera from patients with connective tissue diseases.

Antibodies to Epstein-Barr virus (EBV) were investigated in patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD...
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