Author's Accepted Manuscript
Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats H.O.B Oloyede, T.O. Bello, T.O. Ajiboye, M.O. Salawu
www.elsevier.com/locate/jep
PII: DOI: Reference:
S0378-8741(15)00137-3 http://dx.doi.org/10.1016/j.jep.2015.02.049 JEP9353
To appear in:
Journal of Ethnopharmacology
Received date: 28 November 2014 Revised date: 27 January 2015 Accepted date: 17 February 2015 Cite this article as: H.O.B Oloyede, T.O. Bello, T.O. Ajiboye, M.O. Salawu, Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats, Journal of Ethnopharmacology, http://dx.doi.org/10.1016/j.jep.2015.02.049 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats
1
1
Oloyede, H. O. B., 1Bello, T. O., 2*Ajiboye, T. O. and 1Salawu, M. O.
Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria.
2
Antioxidants, Free Radicals, Functional Foods and Toxicology Research Laboratory,
Department of Biological Sciences, Al-Hikmah University, P.M.B. 1601, Ilorin, Nigeria.
*Corresponding Author: Dr. Taofeek O. Ajiboye, Department of Biological Sciences, Al-Hikmah University, Adewole Hosuing Estate, Adeta Road, PMB1601, Ilorin, Nigeria Mobile: +2348035844608, E-mail: [email protected] Abstract Ethnopharmacological relevance: Dioscoreophyllum cumminsii (Stapf) Diels leaves are used in the management of diabetics in Nigeria. Thus, the antidiabetic activity of aqueous D. cumminsii leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats was investigated. Methodology: Antidiabetic was evaluated in alloxan-induced diabetes rats. Diabetic rats were treated with 50, 100 and 200 mg/kg body weight of the extract. Result: The aqueous extract of D. cumminsii leaves significantly reduced blood glucose level in a dose dependent manner with highest dose producing 72 % reduction after 21 days administration, which compared significantly (P
Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats H.O.B Oloyede, T.O. Bello, T.O. Ajiboye, M.O. Salawu
www.elsevier.com/locate/jep
PII: DOI: Reference:
S0378-8741(15)00137-3 http://dx.doi.org/10.1016/j.jep.2015.02.049 JEP9353
To appear in:
Journal of Ethnopharmacology
Received date: 28 November 2014 Revised date: 27 January 2015 Accepted date: 17 February 2015 Cite this article as: H.O.B Oloyede, T.O. Bello, T.O. Ajiboye, M.O. Salawu, Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats, Journal of Ethnopharmacology, http://dx.doi.org/10.1016/j.jep.2015.02.049 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Antidiabetic and antidyslipidemic activities of aqueous leaf extract of Dioscoreophyllum cumminsii (Stapf) Diels in alloxan-induced diabetic rats
1
1
Oloyede, H. O. B., 1Bello, T. O., 2*Ajiboye, T. O. and 1Salawu, M. O.
Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, P. M. B. 1515, Ilorin, Nigeria.
2
Antioxidants, Free Radicals, Functional Foods and Toxicology Research Laboratory,
Department of Biological Sciences, Al-Hikmah University, P.M.B. 1601, Ilorin, Nigeria.
*Corresponding Author: Dr. Taofeek O. Ajiboye, Department of Biological Sciences, Al-Hikmah University, Adewole Hosuing Estate, Adeta Road, PMB1601, Ilorin, Nigeria Mobile: +2348035844608, E-mail: [email protected] Abstract Ethnopharmacological relevance: Dioscoreophyllum cumminsii (Stapf) Diels leaves are used in the management of diabetics in Nigeria. Thus, the antidiabetic activity of aqueous D. cumminsii leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats was investigated. Methodology: Antidiabetic was evaluated in alloxan-induced diabetes rats. Diabetic rats were treated with 50, 100 and 200 mg/kg body weight of the extract. Result: The aqueous extract of D. cumminsii leaves significantly reduced blood glucose level in a dose dependent manner with highest dose producing 72 % reduction after 21 days administration, which compared significantly (P
