Medical Science - Research Article Antioxidant status in neonatal jaundice before and after phototherapy S. Ayyappan, Sachu Philip, N. Bharathy1, V. Ramesh1, C. Naveen Kumar2, S. Swathi3, A. Arun Kumar4
Department of Biochemistry, Vivekananda Dental College for Women, Trichengodu, Namakkal, 1 Departments of Biochemistry, 2Microbiology and 4Anatomy, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath University, Puducherry, 3Department of Microbiology, Madha Dental College, Chennai, Tamil Nadu, India Address for correspondence: Dr. N. Bharathy, E-mail: [email protected]
Received : 31-10-14 Review completed : 31-10-14 Accepted : 09-11-14
ABSTRACT Background: Neonatal jaundice refers to yellow coloration of the skin and the sclera (whites of the eyes) of newborn babies that result from the accumulation of bilirubin in the skin and mucous membranes. Because bilirubin is potentially toxic to the central nervous system. Genetic disorders of bilirubin conjugation, particularly the common Gilbert’s syndrome, can also contribute to neonatal hyperbilirubinemia. Objective: The aim of this study was to evaluate the lipid per-oxidation and antioxidant enzyme activities in patients with neonatal jaundice before and after phototherapy. Materials and Methods: The study includes 50 neonatal jaundice patients with average age 2-15 days. All patients of neonatal jaundice receiving phototherapy except feeding, cleaning. Subjects selected were from the patients attending Pediatrics Department. Plasma malondialdehyde (MDA), erythrocyte glutathione peroxidase (GPX), superoxide dismutase and catalase (CAT) to monitor the bilirubin level. Results: The results show increased levels of bilirubin compared with controls (P
Department of Biochemistry, Vivekananda Dental College for Women, Trichengodu, Namakkal, 1 Departments of Biochemistry, 2Microbiology and 4Anatomy, Sri Lakshmi Narayana Institute of Medical Sciences, Affiliated to Bharath University, Puducherry, 3Department of Microbiology, Madha Dental College, Chennai, Tamil Nadu, India Address for correspondence: Dr. N. Bharathy, E-mail: [email protected]
Received : 31-10-14 Review completed : 31-10-14 Accepted : 09-11-14
ABSTRACT Background: Neonatal jaundice refers to yellow coloration of the skin and the sclera (whites of the eyes) of newborn babies that result from the accumulation of bilirubin in the skin and mucous membranes. Because bilirubin is potentially toxic to the central nervous system. Genetic disorders of bilirubin conjugation, particularly the common Gilbert’s syndrome, can also contribute to neonatal hyperbilirubinemia. Objective: The aim of this study was to evaluate the lipid per-oxidation and antioxidant enzyme activities in patients with neonatal jaundice before and after phototherapy. Materials and Methods: The study includes 50 neonatal jaundice patients with average age 2-15 days. All patients of neonatal jaundice receiving phototherapy except feeding, cleaning. Subjects selected were from the patients attending Pediatrics Department. Plasma malondialdehyde (MDA), erythrocyte glutathione peroxidase (GPX), superoxide dismutase and catalase (CAT) to monitor the bilirubin level. Results: The results show increased levels of bilirubin compared with controls (P
