Archives of Biochemistry and Biophysics 557 (2014) 1–2
Contents lists available at ScienceDirect
Archives of Biochemistry and Biophysics journal homepage: www.elsevier.com/locate/yabbi
Editorial
Antioxidants and Redox Processes in Health – Bilateral Meeting Brazil-Japan
The ‘‘Antioxidants and Redox Processes in Health’’ (ARPH 2013) Bilateral Meeting Brazil-Japan was held as a Satellite Meeting of VI International Conference of Polyphenols and Health and VIII Meeting of the Society for Free Radical Biology and Medicine-South America at the University of São Paulo, São Paulo, Brazil, October 21–22, 2013. ARPH 2013 was organized with the support of Prof. Yoji Kato, Prof. Marisa H.G. Medeiros and Prof. Paolo Di Mascio. This special issue presents selected and peer-reviewed work communicated at the meeting. Reactive oxygen species (ROS) are ubiquitously generated in all cell types. It is now recognized that these species are generated in the body within a regulated physiological process, and that a disturbance/imbalance in cellular redox state affects signaling pathways involved in the pathophysiology of several chronic degenerative diseases [1]. Thus, the initial concept of oxidative stress [2] where reactive species production was mainly associated to deleterious effects by causing oxidative damage to important biomolecules has been extended to include redox signaling associated with ROS production [3]. The beneficial effects of antioxidants have been extensively investigated. Several antioxidant compounds have been shown to exert a beneficial role against chronic degenerative diseases in experimental studies. Currently, the biggest challenge is the search for effective antioxidant therapies capable of restoring the redox homeostasis in vivo. Brazil has an enormous biodiversity, where the potential pharmacological/therapeutic antioxidant compounds isolated from their biome is still underexplored. In contrast, the area of redox processes has a consolidated excellence in Brazil, and Japan has a long tradition in the study of antioxidants/phytochemicals with therapeutic/nutraceutical potential. Thus, the bilateral meeting aimed to bring together Brazilian and Japanese researchers to discuss the latest advances in the field of antioxidants and redox processes. The meeting was opened with the special keynote lecture by Prof. Helmut Sies and closed by the keynote lecture from Prof. Ohara Augusto. A special invited speaker was Prof. Jean Cadet. The scientific program covered various topics related to antioxidants and redox processes, with particular emphasis on the use of specific and sensitive detection methods of analysis and on mechanistic studies dealing with the identification of potential molecular targets (specific proteins and signaling pathways) for both oxidants and antioxidants in biological systems. As a result, this special issue brings studies showing the detection of quercetin metabolite (quercetin-3-O-glucuronide) on http://dx.doi.org/10.1016/j.abb.2014.07.007 0003-9861/Ó 2014 Elsevier Inc. All rights reserved.
specific regions of human brains [4], the identification of potential molecular targets for antioxidants in breast cancer [5], phase I and phase II drug metabolizing enzymes [6] and specific microRNAs related to angiogenesis [7], mechanistic studies related to DNA promoted by melanin precursors [8], protein damage caused by SOD1 bicarbonate dependent peroxidase activity [9] and the modulation of proteasome activity by S-glutathionylation [10]. Moreover, we have two review articles, one dealing with the issue related to dose-dependent functionality of green tea polyphenols in rodents [11] and the other related to mechanistic aspect of DNA damage [12]. We thank Prof. Helmut Sies and the ABB Editorial Office for the opportunity to publish this special issue. Also we would like to thank the funding agencies from Brazil (FAPESP 2013/08735-0 and CAPES) and Japan (JSPS) and the sponsor companies for the financial support and the University of São Paulo, SBBq and Redoxome (INCT 573530/2008-4; NAP 2011.1.9352.1.8; CEPID 2013/ 07937-8) for all the support for this meeting. Also we would like to thank all the authors who submitted their manuscripts to this special issue and the reviewers for their time and efforts to ensure high quality publications. References [1] W. Dröge, Physiol. Rev. 82 (2002) 47–95. [2] H. Sies, Angew. Chem. Int. Ed. Engl. 25 (1986) 1058–1071. [3] H. Sies, D. Jones, in: G. Fink (Ed.), Encyclopedia of Stress, vol. 3, Academic Press, San Diego, 2007, pp. 45–48. [4] A. Ishisaka, R. Mukai, J. Terao, N. Shibato, Y. Kawai, Specific localization of quercetin-3-O-glucuronide in human brain, Arch. Biochem. Biophys. 557 (2014) 11–17. [5] S. Yamazaki, N. Miyoshi, K. Kawabata, M. Yasuda, M. Shimoi, Quercetin-3-Oglucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking b2-adrenergic signaling, Arch. Biochem. Biophys. 557 (2014) 18–27. [6] T. Zhang, Y. Kimura, S. Jiang, K. Harada, Y. Yamashita, H. Ashida, Luteolin modulates expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways in hepatic cells, Arch. Biochem. Biophys. 557 (2014) 36–46. [7] A. Cuevas, N. Saavedra, M.F. Caralcante, L.A. Salazar, D.S.P. Abdalla, Identification of microRNAs involved in the modulation of pro-angiogenic factors in atherosclerosis by a polyphenol-rich extract from propolis, Arch. Biochem. Biophys. 557 (2014) 28–35. [8] M.C. Pellosi, A. Suzukawa, A.C. Scalfo, P.D. Mascio, C.P.M. Pereira, N.C. de Souza Pinto, D.d.L. Martins, G.R. Martinez, Effects of the melanin precursor 5,6dihydroxy-indole-2-carboxylic acid (DHICA) on DNA damage and repair in the presence of reactive oxygen species, Arch. Biochem. Biophys. 557 (2014) 55– 64. [9] A. Iqbal, V. Paviani, A. Inchabel Moretti, F.R.M. Laurindo, O. Augusto, Oxidation, inactivation and aggregation of protein disulfide isomerase promoted by the bicarbonate-dependent peroxidase activity of human superoxide dismutase, Arch. Biochem. Biophys. 557 (2014) 72–81.
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Editorial / Archives of Biochemistry and Biophysics 557 (2014) 1–2
[10] M. Demasi, A. Hand, E. Ohara, C.L.P. Oliveira, R.N. Bicev, C.A. Bertoncini, L.E.S. Netto, 20s proteasome activity is modified via S-glutathionylation based on intracellular redox status of the yeast saccharomyces cerevisiae: implications for the degradation of oxidized proteins, Arch. Biochem. Biophys. 557 (2014) 65–71. [11] A. Murakami, Dose-dependent functionality and toxicity of green tea polyphenols in experimental rodents, Arch. Biochem. Biophys. 557 (2014) 3– 10. [12] J. Cadet, J.R. Wagner, Oxidatively generated base damage to cellular DNA by hydroxyl radical and one-electron oxidants: similarities and differences, Arch. Biochem. Biophys. 557 (2014) 47–54.
Sayuri Miyamoto Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-000 São Paulo, SP, Brazil E-mail address: [email protected] Junji Terao Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Graduate School of Nutritional Science, The University of Tokushima, Tokushima 770-8503, Japan E-mail addresses: [email protected]
Contents lists available at ScienceDirect
Archives of Biochemistry and Biophysics journal homepage: www.elsevier.com/locate/yabbi
Editorial
Antioxidants and Redox Processes in Health – Bilateral Meeting Brazil-Japan
The ‘‘Antioxidants and Redox Processes in Health’’ (ARPH 2013) Bilateral Meeting Brazil-Japan was held as a Satellite Meeting of VI International Conference of Polyphenols and Health and VIII Meeting of the Society for Free Radical Biology and Medicine-South America at the University of São Paulo, São Paulo, Brazil, October 21–22, 2013. ARPH 2013 was organized with the support of Prof. Yoji Kato, Prof. Marisa H.G. Medeiros and Prof. Paolo Di Mascio. This special issue presents selected and peer-reviewed work communicated at the meeting. Reactive oxygen species (ROS) are ubiquitously generated in all cell types. It is now recognized that these species are generated in the body within a regulated physiological process, and that a disturbance/imbalance in cellular redox state affects signaling pathways involved in the pathophysiology of several chronic degenerative diseases [1]. Thus, the initial concept of oxidative stress [2] where reactive species production was mainly associated to deleterious effects by causing oxidative damage to important biomolecules has been extended to include redox signaling associated with ROS production [3]. The beneficial effects of antioxidants have been extensively investigated. Several antioxidant compounds have been shown to exert a beneficial role against chronic degenerative diseases in experimental studies. Currently, the biggest challenge is the search for effective antioxidant therapies capable of restoring the redox homeostasis in vivo. Brazil has an enormous biodiversity, where the potential pharmacological/therapeutic antioxidant compounds isolated from their biome is still underexplored. In contrast, the area of redox processes has a consolidated excellence in Brazil, and Japan has a long tradition in the study of antioxidants/phytochemicals with therapeutic/nutraceutical potential. Thus, the bilateral meeting aimed to bring together Brazilian and Japanese researchers to discuss the latest advances in the field of antioxidants and redox processes. The meeting was opened with the special keynote lecture by Prof. Helmut Sies and closed by the keynote lecture from Prof. Ohara Augusto. A special invited speaker was Prof. Jean Cadet. The scientific program covered various topics related to antioxidants and redox processes, with particular emphasis on the use of specific and sensitive detection methods of analysis and on mechanistic studies dealing with the identification of potential molecular targets (specific proteins and signaling pathways) for both oxidants and antioxidants in biological systems. As a result, this special issue brings studies showing the detection of quercetin metabolite (quercetin-3-O-glucuronide) on http://dx.doi.org/10.1016/j.abb.2014.07.007 0003-9861/Ó 2014 Elsevier Inc. All rights reserved.
specific regions of human brains [4], the identification of potential molecular targets for antioxidants in breast cancer [5], phase I and phase II drug metabolizing enzymes [6] and specific microRNAs related to angiogenesis [7], mechanistic studies related to DNA promoted by melanin precursors [8], protein damage caused by SOD1 bicarbonate dependent peroxidase activity [9] and the modulation of proteasome activity by S-glutathionylation [10]. Moreover, we have two review articles, one dealing with the issue related to dose-dependent functionality of green tea polyphenols in rodents [11] and the other related to mechanistic aspect of DNA damage [12]. We thank Prof. Helmut Sies and the ABB Editorial Office for the opportunity to publish this special issue. Also we would like to thank the funding agencies from Brazil (FAPESP 2013/08735-0 and CAPES) and Japan (JSPS) and the sponsor companies for the financial support and the University of São Paulo, SBBq and Redoxome (INCT 573530/2008-4; NAP 2011.1.9352.1.8; CEPID 2013/ 07937-8) for all the support for this meeting. Also we would like to thank all the authors who submitted their manuscripts to this special issue and the reviewers for their time and efforts to ensure high quality publications. References [1] W. Dröge, Physiol. Rev. 82 (2002) 47–95. [2] H. Sies, Angew. Chem. Int. Ed. Engl. 25 (1986) 1058–1071. [3] H. Sies, D. Jones, in: G. Fink (Ed.), Encyclopedia of Stress, vol. 3, Academic Press, San Diego, 2007, pp. 45–48. [4] A. Ishisaka, R. Mukai, J. Terao, N. Shibato, Y. Kawai, Specific localization of quercetin-3-O-glucuronide in human brain, Arch. Biochem. Biophys. 557 (2014) 11–17. [5] S. Yamazaki, N. Miyoshi, K. Kawabata, M. Yasuda, M. Shimoi, Quercetin-3-Oglucuronide inhibits noradrenaline-promoted invasion of MDA-MB-231 human breast cancer cells by blocking b2-adrenergic signaling, Arch. Biochem. Biophys. 557 (2014) 18–27. [6] T. Zhang, Y. Kimura, S. Jiang, K. Harada, Y. Yamashita, H. Ashida, Luteolin modulates expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways in hepatic cells, Arch. Biochem. Biophys. 557 (2014) 36–46. [7] A. Cuevas, N. Saavedra, M.F. Caralcante, L.A. Salazar, D.S.P. Abdalla, Identification of microRNAs involved in the modulation of pro-angiogenic factors in atherosclerosis by a polyphenol-rich extract from propolis, Arch. Biochem. Biophys. 557 (2014) 28–35. [8] M.C. Pellosi, A. Suzukawa, A.C. Scalfo, P.D. Mascio, C.P.M. Pereira, N.C. de Souza Pinto, D.d.L. Martins, G.R. Martinez, Effects of the melanin precursor 5,6dihydroxy-indole-2-carboxylic acid (DHICA) on DNA damage and repair in the presence of reactive oxygen species, Arch. Biochem. Biophys. 557 (2014) 55– 64. [9] A. Iqbal, V. Paviani, A. Inchabel Moretti, F.R.M. Laurindo, O. Augusto, Oxidation, inactivation and aggregation of protein disulfide isomerase promoted by the bicarbonate-dependent peroxidase activity of human superoxide dismutase, Arch. Biochem. Biophys. 557 (2014) 72–81.
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Editorial / Archives of Biochemistry and Biophysics 557 (2014) 1–2
[10] M. Demasi, A. Hand, E. Ohara, C.L.P. Oliveira, R.N. Bicev, C.A. Bertoncini, L.E.S. Netto, 20s proteasome activity is modified via S-glutathionylation based on intracellular redox status of the yeast saccharomyces cerevisiae: implications for the degradation of oxidized proteins, Arch. Biochem. Biophys. 557 (2014) 65–71. [11] A. Murakami, Dose-dependent functionality and toxicity of green tea polyphenols in experimental rodents, Arch. Biochem. Biophys. 557 (2014) 3– 10. [12] J. Cadet, J.R. Wagner, Oxidatively generated base damage to cellular DNA by hydroxyl radical and one-electron oxidants: similarities and differences, Arch. Biochem. Biophys. 557 (2014) 47–54.
Sayuri Miyamoto Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, 748, CEP 05508-000 São Paulo, SP, Brazil E-mail address: [email protected] Junji Terao Department of Food Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Graduate School of Nutritional Science, The University of Tokushima, Tokushima 770-8503, Japan E-mail addresses: [email protected]
