AIDS DOI: 10.1097/QAD.0000000000001558 Antiretroviral Initiation is Associated with Increased Skeletal Muscle Area and Fat Content Kristine M. Erlandson1, Suzanne Fiorillo1, Fadzai Masawi1, Ann Scherzinger1, Grace A. McComsey2, Jordan E. Lake3, James H. Stein4, Judith S. Currier5, Todd T. Brown6. 1. University of Colorado- Anschutz Medical Campus; Aurora, CO 2. Case Western University; Cleveland, OH 3. University of Texas Health Sciences Center; Houston, TX 4. University of Wisconsin School of Medicine and Public Health; Madison, WI 5. University of California-Los Angeles; Los Angeles, CA 6. Johns Hopkins University; Baltimore, MD Contact Author and Requests for Reprints: Kristine M. Erlandson 12700 E. 19th Avenue; Mail Stop B168 Aurora, CO 80111 [email protected] Running Head: Muscle changes with ART
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Abstract Objective: A greater burden of physical function impairment occurs in HIVinfected adults; the impact of antiretroviral therapy (ART) initiation on muscle density (less dense = more fat), a measure of muscle quality, is unknown. Design: AIDS Clinical Trials Group Study A5260s, a cardiometabolic substudy of A5257, randomized HIV-infected, ART-naïve adults to ritonavir-boosted atazanavir, darunavir, or raltegravir with tenofovir/emtricitabine backbone. Singleslice abdominal computed tomography (CT) scans from baseline and week 96 were reanalyzed for lean muscle area and density. Methods: Two-sample t-tests described the differences between baseline and week 96 variables. Linear regression analysis was used to explore the role of a priori identified variables and potential confounders. Results: Participants (n=235) were mostly men (90%); 31% were Black nonHispanic; 21% were Hispanic. Over 96 weeks, small but significant increases were seen in oblique/transverse abdominal, rectus, and psoas muscles total area (range 0.21 to 0.83 cm2; p
Copyright © 2017 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.
Abstract Objective: A greater burden of physical function impairment occurs in HIVinfected adults; the impact of antiretroviral therapy (ART) initiation on muscle density (less dense = more fat), a measure of muscle quality, is unknown. Design: AIDS Clinical Trials Group Study A5260s, a cardiometabolic substudy of A5257, randomized HIV-infected, ART-naïve adults to ritonavir-boosted atazanavir, darunavir, or raltegravir with tenofovir/emtricitabine backbone. Singleslice abdominal computed tomography (CT) scans from baseline and week 96 were reanalyzed for lean muscle area and density. Methods: Two-sample t-tests described the differences between baseline and week 96 variables. Linear regression analysis was used to explore the role of a priori identified variables and potential confounders. Results: Participants (n=235) were mostly men (90%); 31% were Black nonHispanic; 21% were Hispanic. Over 96 weeks, small but significant increases were seen in oblique/transverse abdominal, rectus, and psoas muscles total area (range 0.21 to 0.83 cm2; p
