Respiratory Medicine (2014) xx, 1e1
Available online at www.sciencedirect.com
ScienceDirect journal homepage: www.elsevier.com/locate/rmed
LETTER TO THE EDITOR
Arteriel stiffness in patients with bronchial asthma
Dear Editor, We read the article ‘‘Increased arterial stiffness in stable and severe asthma” by Wen-xue Sun and et al. . They concluded that asthmatics had increased arterial stiffness parameters (ASPs) compared to the controls. ASPs may represent the endothelial dysfunction (ED) . ED occurs as a result of known atherosclerotic risk factors such as hypertension, smoking, hypercholesterolemia, diabetes mellitus (DM), or aging. However, increased arterial stiffness is an indicator of chronic kidney disease, cerebrovascular disease and peripheral arterial disease (PAD), hypothyroidism, malignancy  and alcohol consumption. Furthermore, some medications such as antihypertensive treatment including angiotensin-converting enzyme inhibitors, angiotensin receptor blocker, statins used may influence ASPs. Moreover, we previously concluded that ASPs were higher in patients with Behc ¸et’s disease (BD) without significant cardiovascular involvement . We also reported that ASPs were significantly higher in psoriasis patients compared to controls . So, it would be better, if the authors had mentioned some inflammatory diseases such as psoriasis and BD that can be related to the ASPs. As a conclusion, without other inflammatory markers, arterial stiffness alone may not supply more information to clinicians about the severity in patients with BA . It would have been better, if these factors were included in the paper.
Conflict of interest There is no conflict of interests.
References  Sun W, Jin D, Li Y, Wang R. ScienceDirect increased arterial stiffness in stable and severe asthma. Respir Med Elsevier Ltd 2013;246:1e6.
 Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L, et al. Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001 May 15;37(5):1236e41.  Balta S, Demırkol S, Unlu M, Cakar M, Arslan Z, Akhan M. Higher pentraxin-3 level in patients with metabolic syndrome. Med Princ Pract 2013 Jan;22(5):513e4.  Balta I, Balta S, Koryurek OM, Demirkol S, Celik T, Akbay G, et al. Mean platelet volume is associated with aortic arterial stiffness in patients with Behc ¸et’s disease without significant cardiovascular involvement. J Eur Acad Dermatol Venereol; 2013 Oct 25.  Balta I, Balta S, Demirkol S, Celik T, Ekiz O, Cakar M, et al. Aortic arterial stiffness is a moderate predictor of cardiovascular disease in patients with psoriasis vulgaris. Angiology 2014;65(1):74e8.  Balta S, Cakar M, Demirkol S, Unlu M, Kucuk U, Arslan Z. Arterial stiffness itself without other inflammatory markers may not provide information to clinicians. J Clin Hypertens 2013;15(4):303. Greenwich.
Sevket Balta* Department of Cardiology, Eskis‚ehir Military Hospital, Eskis‚ehir, Turkey Mustafa Demir Department of Cardiology, Gulhane Medical Academy Ankara, Turkey Cengiz Ozturk Department of Cardiology, Eskis‚ehir Military Hospital, Eskis‚ehir, Turkey Turgay Celik Department of Cardiology, Gulhane Medical Academy Ankara, Turkey *Corresponding author. Department of Cardiology, Eskisehir Military Hospital, Vis‚nelik Mah., Atatu ¨rk Cd., 26020, Akarbas‚ı, Eskis‚ehir, Turkey. Tel.: þ90 222 220 45 30; fax: þ90 222 230 34 33. E-mail addresses: [email protected]
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1 December 2013
http://dx.doi.org/10.1016/j.rmed.2013.12.017 0954-6111/ª 2014 Elsevier Ltd. All rights reserved.
Please cite this article in press as: Balta S, et al., Arteriel stiffness in patients with bronchial asthma, Respiratory Medicine (2014), http:// dx.doi.org/10.1016/j.rmed.2013.12.017