Chronobiology International The Journal of Biological and Medical Rhythm Research
ISSN: 0742-0528 (Print) 1525-6073 (Online) Journal homepage: http://www.tandfonline.com/loi/icbi20
Aspirin, Platelet Aggregation, and the Circadian Variation of Acute Thrombotic Events Paul M. Ridker, Stefan N. Willich, James E. Muller & Charles H. Hennekens To cite this article: Paul M. Ridker, Stefan N. Willich, James E. Muller & Charles H. Hennekens (1991) Aspirin, Platelet Aggregation, and the Circadian Variation of Acute Thrombotic Events, Chronobiology International, 8:5, 327-335, DOI: 10.3109/07420529109059169 To link to this article: http://dx.doi.org/10.3109/07420529109059169
Published online: 01 Dec 2010.
Submit your article to this journal
Article views: 18
View related articles
Citing articles: 1 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=icbi20 Download by: [137.189.171.235]
Date: 12 June 2016, At: 16:46
Chronobiology International Vol. 8, No. 5, pp. 327-335 0 199 I International Society of Chronobiology
Aspirin, Platelet Aggregation, and the Circadian Variation of Acute Thrombotic Events *$Paul M. Ridker, t$Stefan N. Willich, tSJames E. Muller, and *#Charles H. Hennekens
Downloaded by [] at 16:46 12 June 2016
*Department of Medicine, Brigham and Women’s Hospital; ?Institute for the Prevention of Cardiovascular Disease, New England Deaconess Hospital; and the SHarvard Medical School, Boston, Massachusetts, U.S.A.
Summary: The onset of several acute cardiovascular diseases occurs in a circadian pattern, with a peak incidence in the hours soon after awakening. This finding, coupled with laboratory data that confirm a surge in platelet activation during the early morning hours, suggests that acute changes in platelet aggregability may be an important trigger of thrombosis. Therefore, the efficacy of antiplatelet agents, such as aspirin, in reducing risks of vascular occlusion may result, at least in part, from a blunting of these short-term changes in platelet aggregability. In this review, clinical and laboratory evidence describing these cyclical changes is discussed, as is current evidence of the effects of aspirin on platelet function and the circadian variation of acute thrombosis. Key Words: Acute thrombosis-Circadian variation-Platelet aggregation-Antiplatelet agents.
Over the past decade, evidence has accumulated suggesting that the circadian variation of acute thrombosis is related to diurnal changes in platelet function and that antiplatelet agents, such as aspirin, may exert part of their antithrombotic effect through a blunting of this circadian process. These data derive primarily from large randomized trials of antiplatelet agents in the prevention of acute thrombosis; laboratory and epidemiologicstudies describing circadian rhythms of thrombosis and platelet aggregation; and clinical trials analyzing the effect of aspirin on the circadian variation of acute myocardial infarction.
THE ROLE OF ASPIRIN IN THE PREVENTION OF ACUTE THROMBOTIC DISORDERS Aspirin irreversibly inhibits platelet cycloxygenase, resulting in a marked inhibition of platelet function ( 1,2). This inhibition dramatically reduces the risk of acute thrombosis, an effect that can be achieved with
ISSN: 0742-0528 (Print) 1525-6073 (Online) Journal homepage: http://www.tandfonline.com/loi/icbi20
Aspirin, Platelet Aggregation, and the Circadian Variation of Acute Thrombotic Events Paul M. Ridker, Stefan N. Willich, James E. Muller & Charles H. Hennekens To cite this article: Paul M. Ridker, Stefan N. Willich, James E. Muller & Charles H. Hennekens (1991) Aspirin, Platelet Aggregation, and the Circadian Variation of Acute Thrombotic Events, Chronobiology International, 8:5, 327-335, DOI: 10.3109/07420529109059169 To link to this article: http://dx.doi.org/10.3109/07420529109059169
Published online: 01 Dec 2010.
Submit your article to this journal
Article views: 18
View related articles
Citing articles: 1 View citing articles
Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=icbi20 Download by: [137.189.171.235]
Date: 12 June 2016, At: 16:46
Chronobiology International Vol. 8, No. 5, pp. 327-335 0 199 I International Society of Chronobiology
Aspirin, Platelet Aggregation, and the Circadian Variation of Acute Thrombotic Events *$Paul M. Ridker, t$Stefan N. Willich, tSJames E. Muller, and *#Charles H. Hennekens
Downloaded by [] at 16:46 12 June 2016
*Department of Medicine, Brigham and Women’s Hospital; ?Institute for the Prevention of Cardiovascular Disease, New England Deaconess Hospital; and the SHarvard Medical School, Boston, Massachusetts, U.S.A.
Summary: The onset of several acute cardiovascular diseases occurs in a circadian pattern, with a peak incidence in the hours soon after awakening. This finding, coupled with laboratory data that confirm a surge in platelet activation during the early morning hours, suggests that acute changes in platelet aggregability may be an important trigger of thrombosis. Therefore, the efficacy of antiplatelet agents, such as aspirin, in reducing risks of vascular occlusion may result, at least in part, from a blunting of these short-term changes in platelet aggregability. In this review, clinical and laboratory evidence describing these cyclical changes is discussed, as is current evidence of the effects of aspirin on platelet function and the circadian variation of acute thrombosis. Key Words: Acute thrombosis-Circadian variation-Platelet aggregation-Antiplatelet agents.
Over the past decade, evidence has accumulated suggesting that the circadian variation of acute thrombosis is related to diurnal changes in platelet function and that antiplatelet agents, such as aspirin, may exert part of their antithrombotic effect through a blunting of this circadian process. These data derive primarily from large randomized trials of antiplatelet agents in the prevention of acute thrombosis; laboratory and epidemiologicstudies describing circadian rhythms of thrombosis and platelet aggregation; and clinical trials analyzing the effect of aspirin on the circadian variation of acute myocardial infarction.
THE ROLE OF ASPIRIN IN THE PREVENTION OF ACUTE THROMBOTIC DISORDERS Aspirin irreversibly inhibits platelet cycloxygenase, resulting in a marked inhibition of platelet function ( 1,2). This inhibition dramatically reduces the risk of acute thrombosis, an effect that can be achieved with
