Flasche et al. BMC Medicine (2017) 15:113 DOI 10.1186/s12916-017-0882-9
RESEARCH ARTICLE
Open Access
Assessing the efficiency of catch-up campaigns for the introduction of pneumococcal conjugate vaccine: a modelling study based on data from PCV10 introduction in Kilifi, Kenya Stefan Flasche1* , John Ojal1,2, Olivier Le Polain de Waroux1, Mark Otiende2, Katherine L. O’Brien3, Moses Kiti2, D. James Nokes2,4, W John Edmunds1 and J. Anthony G. Scott1,2
Abstract Background: The World Health Organisation recommends the use of catch-up campaigns as part of the introduction of pneumococcal conjugate vaccines (PCVs) to accelerate herd protection and hence PCV impact. The value of a catch-up campaign is a trade-off between the costs of vaccinating additional age groups and the benefit of additional direct and indirect protection. There is a paucity of observational data, particularly from low- and middle-income countries, to quantify the optimal breadth of such catch-up campaigns. Methods: In Kilifi, Kenya, PCV10 was introduced in 2011 using the three-dose Expanded Programme on Immunisation infant schedule and a catch-up campaign in children
RESEARCH ARTICLE
Open Access
Assessing the efficiency of catch-up campaigns for the introduction of pneumococcal conjugate vaccine: a modelling study based on data from PCV10 introduction in Kilifi, Kenya Stefan Flasche1* , John Ojal1,2, Olivier Le Polain de Waroux1, Mark Otiende2, Katherine L. O’Brien3, Moses Kiti2, D. James Nokes2,4, W John Edmunds1 and J. Anthony G. Scott1,2
Abstract Background: The World Health Organisation recommends the use of catch-up campaigns as part of the introduction of pneumococcal conjugate vaccines (PCVs) to accelerate herd protection and hence PCV impact. The value of a catch-up campaign is a trade-off between the costs of vaccinating additional age groups and the benefit of additional direct and indirect protection. There is a paucity of observational data, particularly from low- and middle-income countries, to quantify the optimal breadth of such catch-up campaigns. Methods: In Kilifi, Kenya, PCV10 was introduced in 2011 using the three-dose Expanded Programme on Immunisation infant schedule and a catch-up campaign in children
