A C TA Obstetricia et Gynecologica
AOGS O R I G I N A L R E S E A R C H A R T I C L E
Association between cerebral palsy and microscopically verified placental infarction in extremely preterm infants MARIE-THERESE VINNARS1,*, BRIGITTE VOLLMER2,3, JOSEFINE NASIELL1, NIKOS PAPADOGIANNAKIS4 & MAGNUS WESTGREN1 1
Department of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska Institute, Stockholm, 2Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden, 3Clinical Neurosciences, Faculty of Medicine, University of Southampton, Southampton, UK, and 4Department of Laboratory Medicine, Division of Pathology, Karolinska Institute, Stockholm, Sweden
Key words Cerebral palsy, fetal medicine, neurodisability, neurodevelopmental disability, neurodevelopmental outcome, neurodevelopment, placenta and preterm delivery Correspondence Marie-Therese Vinnars, Department of € €ldsviks Obstetrics and Gynecology, Ornsk o € € Hospital, 891 89 Ornskoldsvik, Sweden. E-mail: [email protected] Conflict of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article. Please cite this article as: Vinnars M-T, Vollmer B, Nasiell J, Papadogiannakis N, Westgren M. Association between cerebral palsy and microscopically verified placental infarction in extremely preterm infants. Acta Obstet Gynecol Scand 2015; 94:976–982. Received: 8 November 2014 Accepted: 1 June 2015 DOI: 10.1111/aogs.12688
Abstract Introduction. Previously, cerebral palsy has been associated with placental infarctions diagnosed macroscopically by midwifes. However, the risk of misclassification of infarctionsis is high without a histological verification. Therefore, the objective of this study was to study placental histopathology in relation to developmental outcome at 2.5 years corrected age in a population born extremely preterm. Material and methods. A prospective cohort study was carried out at Karolinska University Hospital, Stockholm, Sweden on a population of 139 live born infants delivered
AOGS O R I G I N A L R E S E A R C H A R T I C L E
Association between cerebral palsy and microscopically verified placental infarction in extremely preterm infants MARIE-THERESE VINNARS1,*, BRIGITTE VOLLMER2,3, JOSEFINE NASIELL1, NIKOS PAPADOGIANNAKIS4 & MAGNUS WESTGREN1 1
Department of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, Karolinska Institute, Stockholm, 2Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden, 3Clinical Neurosciences, Faculty of Medicine, University of Southampton, Southampton, UK, and 4Department of Laboratory Medicine, Division of Pathology, Karolinska Institute, Stockholm, Sweden
Key words Cerebral palsy, fetal medicine, neurodisability, neurodevelopmental disability, neurodevelopmental outcome, neurodevelopment, placenta and preterm delivery Correspondence Marie-Therese Vinnars, Department of € €ldsviks Obstetrics and Gynecology, Ornsk o € € Hospital, 891 89 Ornskoldsvik, Sweden. E-mail: [email protected] Conflict of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article. Please cite this article as: Vinnars M-T, Vollmer B, Nasiell J, Papadogiannakis N, Westgren M. Association between cerebral palsy and microscopically verified placental infarction in extremely preterm infants. Acta Obstet Gynecol Scand 2015; 94:976–982. Received: 8 November 2014 Accepted: 1 June 2015 DOI: 10.1111/aogs.12688
Abstract Introduction. Previously, cerebral palsy has been associated with placental infarctions diagnosed macroscopically by midwifes. However, the risk of misclassification of infarctionsis is high without a histological verification. Therefore, the objective of this study was to study placental histopathology in relation to developmental outcome at 2.5 years corrected age in a population born extremely preterm. Material and methods. A prospective cohort study was carried out at Karolinska University Hospital, Stockholm, Sweden on a population of 139 live born infants delivered
