Systematic Review
Association between Environmental Dioxin-Related Toxicants Exposure and Adverse Pregnancy Outcome: Systematic Review and Meta-Analysis Xinjuan Pan, Ph.D.1, 2, Xiaozhuan Liu, Ph.D.1, 2, Xing Li, M.D.1, Nannan Niu, M.D.1, Xinjuan Yin, M.D.1, Ning Li, Ph.D.1, Zengli Yu, Ph.D.1* 1. College of Public Health, Zhengzhou University, Zhengzhou, China 2. Medical College, Henan University of Science and Technology, Luoyang, China
Abstract
Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. However, there were inconsistent results in epidemiology studies. In view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. Comprehensive literature searches were performed to search for relevant articles published in English up to 15 May 2012. In total, we identified 15 studies which included 9 cohort and 6 case control studies. The Cochrane Q test and index of heterogeneity (I2) were used to evaluate heterogeneity. In either cohort studies (I2=0.89, p
Association between Environmental Dioxin-Related Toxicants Exposure and Adverse Pregnancy Outcome: Systematic Review and Meta-Analysis Xinjuan Pan, Ph.D.1, 2, Xiaozhuan Liu, Ph.D.1, 2, Xing Li, M.D.1, Nannan Niu, M.D.1, Xinjuan Yin, M.D.1, Ning Li, Ph.D.1, Zengli Yu, Ph.D.1* 1. College of Public Health, Zhengzhou University, Zhengzhou, China 2. Medical College, Henan University of Science and Technology, Luoyang, China
Abstract
Dioxin-related compounds are associated with teratogenic and mutagenic risks in laboratory animals, and result in adverse pregnancy outcomes. However, there were inconsistent results in epidemiology studies. In view of this difference, we conducted a systematic review and meta-analysis to examine this association and to assess the heterogeneity among studies. Comprehensive literature searches were performed to search for relevant articles published in English up to 15 May 2012. In total, we identified 15 studies which included 9 cohort and 6 case control studies. The Cochrane Q test and index of heterogeneity (I2) were used to evaluate heterogeneity. In either cohort studies (I2=0.89, p
