www.nephropathol.com Jalalzadeh M et al
DOI: 10.5812/nephropathol.8115
J Nephropathology. 2012; 1(3): 170-176
Journal of Nephropathology Association between helicobacter pylori infection and body mass index, before and after eradication of infection in hemodialysis batients Mojgan Jalalzadeh1, Mohammad Hassan Ghadiani 2,*, Nouraddin Mousavinasab3 Departments of Nephrology , Imam Hossein Hospital , Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Nephrology. Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3 Department of Social Medicine , Zanjan University of Medical Sciences, Zanjan, Iran. 1 2
Article type:
Original Article
Article history:
Received: 21 May 2012 Revised: 30 May 2012 Accepted: 2 June 2012 Published online: 1 October 2012
DOI: 10.5812/nephropathol.8115
Keywords:
Hemodialysis H. pylori infection Body Mass Index
ABSTRACT Background: In dialysis patients, chronic infections have been associated with cachexia and anorexia. Objectives: This study was carried out to determine the association between Helicobacter pylori (HP) infection and body mass index (BMI) in hemodialysis (HD) patients. Patients and Methods: Ninety eight patients were divided into two groups of negative (group 1) and positive (group 2), for HP. BMI of all patients was measured at the beginning and in group2 after six months following eradication of HP. Before dialysis, various paraclinical parameters were checked at the same intervals. Results: Fifty-nine patients were enrolled in group 1 and 39 patients in group 2. The means of BMI in groups 1 and 2 were 23.4±3.7 and 25.8±4.4kg/m², respectively. Prior to the study, there was no significant difference for BMI, duration of HD and paraclinic data between two groups. Group 2 took anti HP therapy and eradication occurred in 30 of them. In this group six months after eradication of HP, the BMI was significantly decreased from 25.02±4.4 to 24.4±4.0 kg/m² (P = 0.001). Also six months following the eradication of HP, the mean of serum albumin level was significantly declined from 4.2 to 3.7 g/L (P0.05). However, there was significant difference for age between two groups (P=0.02) (Table 1). The mean of BMI was 23.4±3.7 kg/ m2 in group 1 and 25.8±4.4 kg/m2 in group 2, 172
Journal of Nephropathology, Vol. 1, No 3 October 2012
and there was no significantly difference between the two groups as shown in Table 1 (P=0.07). The BMI in the female and male groups was 23.5 ± 4.7 kg/m2 and 24.5 ± 3.5 kg/m2, respectively (P=0.26). Table1: Comparing the HP seronegative (Group-1) and positive (Group-2) patients. variables Age (years) Gender (F/M) Duration of dialysis (Hour) BMI (kg/m2) Alb (mg/dL) TG (mg/dL) Chol (mg/dL) BUN (mg/dL)
Group 1 (n:59) 51.1 ±16.4 26/33 33.8 ± 33.8
Group 2 (n:39) 59.0 ± 16.2 18/21 43.1 ± 35.4
P value
23.4 ± 3.7 4.2 ± 0.8 158.0±107 174.5±45.9 76.7±33.0
25.8 ± 4.4 4.2 ± 0.6 158.8±115.1 175±4.4 94.2±47.9
0.07 0.96 0.31* 0.89 0.10*
0.02 0.84 0.10*
Cr (mg/dL) 9.7±3.5 10.0 ± 2.9 0.68 Hgb (g/dL) 10.1±1.9 10.4±2.2 0.48 Ca (mg/dL) 9.4±1.1 9.6±1.1 0.44 P (mg/dL) 6.2±3.08 5.7±1.7 0.95* BMI: Body Mass Index, TG: Triglyceride, Chol: Cholesterol, Cr: Creatinine, P: phosphorus *Mann Whitney U test
The causes of ESRD among the patients were as follows: diabetic mellitus 19.6%, hypertension 33.3%, glomerolonephritis 3.9%, urologic problem 2%, polycystic kidney disease 3.9%, poisoning 2%, lupus nephritis 2% and unknown etiology 33.3% of cases. The mean of kt/v for patients was 1.21±0.14. The BMI of infected group before eradication and six months after was 25.02 ± 4.4 and 24.4 ± 4.4, respectively (Table 2) (P=0.001). Thirty-nine patients took anti HP drug regiment and 37 of them completed the treatment period. Two patients died before the start of treatment and were excluded from the study. A few number of patients complained of gastro-intestitinal symptoms but there was no severe enough to compel them to drop out of the study. Eradication was successful in 30 patients www.nephropathol.com
H. pylori and body mass index
(81.1%), while seven patients (18.9%) remained positive. In group 2, six months after eradication of HP, the BMI was significantly decreased from 25.02±4.4 to 24.4±4.0 (P=0.001) and the mean of serum Alb level was significantly decreased from 4.2 to 3.7 (P
DOI: 10.5812/nephropathol.8115
J Nephropathology. 2012; 1(3): 170-176
Journal of Nephropathology Association between helicobacter pylori infection and body mass index, before and after eradication of infection in hemodialysis batients Mojgan Jalalzadeh1, Mohammad Hassan Ghadiani 2,*, Nouraddin Mousavinasab3 Departments of Nephrology , Imam Hossein Hospital , Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Nephrology. Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 3 Department of Social Medicine , Zanjan University of Medical Sciences, Zanjan, Iran. 1 2
Article type:
Original Article
Article history:
Received: 21 May 2012 Revised: 30 May 2012 Accepted: 2 June 2012 Published online: 1 October 2012
DOI: 10.5812/nephropathol.8115
Keywords:
Hemodialysis H. pylori infection Body Mass Index
ABSTRACT Background: In dialysis patients, chronic infections have been associated with cachexia and anorexia. Objectives: This study was carried out to determine the association between Helicobacter pylori (HP) infection and body mass index (BMI) in hemodialysis (HD) patients. Patients and Methods: Ninety eight patients were divided into two groups of negative (group 1) and positive (group 2), for HP. BMI of all patients was measured at the beginning and in group2 after six months following eradication of HP. Before dialysis, various paraclinical parameters were checked at the same intervals. Results: Fifty-nine patients were enrolled in group 1 and 39 patients in group 2. The means of BMI in groups 1 and 2 were 23.4±3.7 and 25.8±4.4kg/m², respectively. Prior to the study, there was no significant difference for BMI, duration of HD and paraclinic data between two groups. Group 2 took anti HP therapy and eradication occurred in 30 of them. In this group six months after eradication of HP, the BMI was significantly decreased from 25.02±4.4 to 24.4±4.0 kg/m² (P = 0.001). Also six months following the eradication of HP, the mean of serum albumin level was significantly declined from 4.2 to 3.7 g/L (P0.05). However, there was significant difference for age between two groups (P=0.02) (Table 1). The mean of BMI was 23.4±3.7 kg/ m2 in group 1 and 25.8±4.4 kg/m2 in group 2, 172
Journal of Nephropathology, Vol. 1, No 3 October 2012
and there was no significantly difference between the two groups as shown in Table 1 (P=0.07). The BMI in the female and male groups was 23.5 ± 4.7 kg/m2 and 24.5 ± 3.5 kg/m2, respectively (P=0.26). Table1: Comparing the HP seronegative (Group-1) and positive (Group-2) patients. variables Age (years) Gender (F/M) Duration of dialysis (Hour) BMI (kg/m2) Alb (mg/dL) TG (mg/dL) Chol (mg/dL) BUN (mg/dL)
Group 1 (n:59) 51.1 ±16.4 26/33 33.8 ± 33.8
Group 2 (n:39) 59.0 ± 16.2 18/21 43.1 ± 35.4
P value
23.4 ± 3.7 4.2 ± 0.8 158.0±107 174.5±45.9 76.7±33.0
25.8 ± 4.4 4.2 ± 0.6 158.8±115.1 175±4.4 94.2±47.9
0.07 0.96 0.31* 0.89 0.10*
0.02 0.84 0.10*
Cr (mg/dL) 9.7±3.5 10.0 ± 2.9 0.68 Hgb (g/dL) 10.1±1.9 10.4±2.2 0.48 Ca (mg/dL) 9.4±1.1 9.6±1.1 0.44 P (mg/dL) 6.2±3.08 5.7±1.7 0.95* BMI: Body Mass Index, TG: Triglyceride, Chol: Cholesterol, Cr: Creatinine, P: phosphorus *Mann Whitney U test
The causes of ESRD among the patients were as follows: diabetic mellitus 19.6%, hypertension 33.3%, glomerolonephritis 3.9%, urologic problem 2%, polycystic kidney disease 3.9%, poisoning 2%, lupus nephritis 2% and unknown etiology 33.3% of cases. The mean of kt/v for patients was 1.21±0.14. The BMI of infected group before eradication and six months after was 25.02 ± 4.4 and 24.4 ± 4.4, respectively (Table 2) (P=0.001). Thirty-nine patients took anti HP drug regiment and 37 of them completed the treatment period. Two patients died before the start of treatment and were excluded from the study. A few number of patients complained of gastro-intestitinal symptoms but there was no severe enough to compel them to drop out of the study. Eradication was successful in 30 patients www.nephropathol.com
H. pylori and body mass index
(81.1%), while seven patients (18.9%) remained positive. In group 2, six months after eradication of HP, the BMI was significantly decreased from 25.02±4.4 to 24.4±4.0 (P=0.001) and the mean of serum Alb level was significantly decreased from 4.2 to 3.7 (P
