Accepted Manuscript Association of Mucoid Degeneration of Anterior Cruciate Ligament with Knee Meniscal and Cartilage Damage Robert M. Kwee, MD, PhD, Shivani Ahlawat, MD, Andrew J. Kompel, MD, John N. Morelli, MD, Laura M. Fayad, MD, Bashir A. Zikria, MD, Shadpour Demehri, MD PII:

S1063-4584(15)01133-4

DOI:

10.1016/j.joca.2015.04.013

Reference:

YJOCA 3462

To appear in:

Osteoarthritis and Cartilage

Received Date: 11 November 2014 Accepted Date: 14 April 2015

Please cite this article as: Kwee RM, Ahlawat S, Kompel AJ, Morelli JN, Fayad LM, Zikria BA, Demehri S, Association of Mucoid Degeneration of Anterior Cruciate Ligament with Knee Meniscal and Cartilage Damage, Osteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.013. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT

Association of Mucoid Degeneration of Anterior Cruciate Ligament with Knee Meniscal and Cartilage Damage

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Robert M. Kwee, MD, PhD1,2 Shivani Ahlawat, MD1 Andrew J. Kompel, MD1

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John N. Morelli, MD1

Bashir A. Zikria, MD3 Shadpour Demehri, MD1

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Laura M. Fayad MD1

Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins

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University School of Medicine, Baltimore, MD, United States

Department of Radiology, Maastricht University Medical Center, Maastricht, The

Netherlands

Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine,

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Baltimore, MD, United States

Corresponding author: Shadpour Demehri, MD

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 Tel: (410) 614-6179

ACCEPTED MANUSCRIPT

Fax: (443) 287-6403 E-mail: [email protected]

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Running headline: ACL mucoid degeneration

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Abstract

Objective. To assess the prevalence of anterior cruciate ligament (ACL) mucoid

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degeneration in patients referred for routine knee magnetic resonance (MR) imaging, and its association with age and structural joint damage.

Method. Four independent radiologists assessed 413 consecutive knee MR examinations for the presence of a normal or ruptured ACL, or ACL mucoid degeneration. Knees with

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ACL mucoid degeneration were frequency matched by age, sex, and MR field strength with consecutive control knees with a normal ACL (1:2 ratio). Differences in meniscal and cartilage damage of the tibiofemoral compartments, as determined by the Whole-

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Organ MR Imaging Score (WORMS) system, were compared by Mann–Whitney U tests. Multivariable logistic regression analysis identified the association of ACL mucoid

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degeneration with severe MTFC cartilage damage (WORMS≥5). Results. Patients with ACL mucoid degeneration (n=36; 36% males; median age 55.5 years, range: 26-81) were older than patients with a normal (P