HHS Public Access Author manuscript Author Manuscript
Obstet Gynecol. Author manuscript; available in PMC 2017 May 01. Published in final edited form as: Obstet Gynecol. 2016 May ; 127(5): 819–827. doi:10.1097/AOG.0000000000001398.
Association of Ovary-Sparing Hysterectomy With Ovarian Reserve
Author Manuscript
Emanuel C. Trabuco, MD, MS, Patricia G. Moorman, PhD, Alicia Algeciras-Schimnich, PhD, Amy L. Weaver, MS, and William A. Cliby, MD Department of Obstetrics and Gynecology (Drs Trabuco and Cliby), Department of Laboratory Medicine and Pathology (Dr Algeciras-Schimnich), and Division of Biomedical Statistics and Informatics (Ms Weaver), Mayo Clinic, Rochester, Minnesota, and Department of Community and Family Medicine (Dr Moorman), Duke University Medical Center, Durham, North Carolina
Abstract Objective—To evaluate the association of hysterectomy on ovarian function by comparing antimüllerian hormone, a marker of ovarian reserve, before and after hysterectomy.
Author Manuscript
Methods—The Prospective Research on Ovarian Function study prospectively followed 1) premenopausal women undergoing ovary-sparing hysterectomy for benign indications and 2) a referent cohort with similar age distributions and intact reproductive organs; they reported that women undergoing hysterectomy became menopausal 1.9 years earlier than referents. In a planned secondary analysis, baseline antimüllerian hormone levels and the absolute change and percent change in antimüllerian hormone levels between baseline and 1-year follow-up were compared between groups. Results—Baseline median antimüllerian hormone levels were similar between the hysterectomy group (n=148) and the referent group (n=172). After 1 year, hysterectomy patients had a significantly greater median percent decrease (−40.7% vs −20.9%; P
Obstet Gynecol. Author manuscript; available in PMC 2017 May 01. Published in final edited form as: Obstet Gynecol. 2016 May ; 127(5): 819–827. doi:10.1097/AOG.0000000000001398.
Association of Ovary-Sparing Hysterectomy With Ovarian Reserve
Author Manuscript
Emanuel C. Trabuco, MD, MS, Patricia G. Moorman, PhD, Alicia Algeciras-Schimnich, PhD, Amy L. Weaver, MS, and William A. Cliby, MD Department of Obstetrics and Gynecology (Drs Trabuco and Cliby), Department of Laboratory Medicine and Pathology (Dr Algeciras-Schimnich), and Division of Biomedical Statistics and Informatics (Ms Weaver), Mayo Clinic, Rochester, Minnesota, and Department of Community and Family Medicine (Dr Moorman), Duke University Medical Center, Durham, North Carolina
Abstract Objective—To evaluate the association of hysterectomy on ovarian function by comparing antimüllerian hormone, a marker of ovarian reserve, before and after hysterectomy.
Author Manuscript
Methods—The Prospective Research on Ovarian Function study prospectively followed 1) premenopausal women undergoing ovary-sparing hysterectomy for benign indications and 2) a referent cohort with similar age distributions and intact reproductive organs; they reported that women undergoing hysterectomy became menopausal 1.9 years earlier than referents. In a planned secondary analysis, baseline antimüllerian hormone levels and the absolute change and percent change in antimüllerian hormone levels between baseline and 1-year follow-up were compared between groups. Results—Baseline median antimüllerian hormone levels were similar between the hysterectomy group (n=148) and the referent group (n=172). After 1 year, hysterectomy patients had a significantly greater median percent decrease (−40.7% vs −20.9%; P
