J Huazhong Univ Sci Technol [Med Sci] 35(2):212-218,2015 DOI 10.1007/s11596-015-1413-6 J Huazhong Univ Sci Technol［Med Sci］ 35(2):2015
212
Association of Serum Dkk-1 Levels with β-catenin in Patients with Postmenopausal Osteoporosis* Jun TIAN (田 峻)1, 2†, Xiao-juan XU (徐晓娟)1†, Lin SHEN (沈 霖)1#, Yan-ping YANG (杨艳萍)1, Rui ZHU (朱 锐)1, Bo SHUAI (帅 波)1, Xi-Wen ZHU (朱习文)1, Cheng-gang LI (李成刚)1, Chen MA (马 陈)1, Lin LV (吕 林)1 1 Department of Integrated Traditional Chinese Medicine and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2 Department of Rehabilitation Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2015
Summary: Wnt signaling plays an important role in the bone development and remodeling. The Wnt antagonist Dkk-1 is a potent inhibitor of bone formation. The aims of this study were firstly to compare the serum Dkk-1 levels in postmenopausal osteoporosis patients with age-matched healthy controls, and secondly, to assess the possible relationship between Dkk-1 and β-catenin, sclerostin, or bone turnover markers [CTX, PINP, N-MID-OT and 25(OH)D] in the setting of postmenopausal osteoporosis. A total of 350 patients with postmenopausal osteoporosis and 150 age-matched healthy controls were enrolled, and the serum levels of Dkk-1, β-catenin, sclerostin, OPG, and RANKL were detected by ELISA, and bone turnover markers [CTX, PINP, N-MID-OT and 25(OH)D] were measured by Roche electrochemiluminescence system in two groups. Serum Dkk-1 levels were significantly higher in postmenopausal osteoporosis group than in control group (P
212
Association of Serum Dkk-1 Levels with β-catenin in Patients with Postmenopausal Osteoporosis* Jun TIAN (田 峻)1, 2†, Xiao-juan XU (徐晓娟)1†, Lin SHEN (沈 霖)1#, Yan-ping YANG (杨艳萍)1, Rui ZHU (朱 锐)1, Bo SHUAI (帅 波)1, Xi-Wen ZHU (朱习文)1, Cheng-gang LI (李成刚)1, Chen MA (马 陈)1, Lin LV (吕 林)1 1 Department of Integrated Traditional Chinese Medicine and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2 Department of Rehabilitation Medicine, Zhongnan Hospital, Wuhan University, Wuhan 430071, China © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2015
Summary: Wnt signaling plays an important role in the bone development and remodeling. The Wnt antagonist Dkk-1 is a potent inhibitor of bone formation. The aims of this study were firstly to compare the serum Dkk-1 levels in postmenopausal osteoporosis patients with age-matched healthy controls, and secondly, to assess the possible relationship between Dkk-1 and β-catenin, sclerostin, or bone turnover markers [CTX, PINP, N-MID-OT and 25(OH)D] in the setting of postmenopausal osteoporosis. A total of 350 patients with postmenopausal osteoporosis and 150 age-matched healthy controls were enrolled, and the serum levels of Dkk-1, β-catenin, sclerostin, OPG, and RANKL were detected by ELISA, and bone turnover markers [CTX, PINP, N-MID-OT and 25(OH)D] were measured by Roche electrochemiluminescence system in two groups. Serum Dkk-1 levels were significantly higher in postmenopausal osteoporosis group than in control group (P
