Pediatric Nephrology
Pediatr Nephrol (1992) 6 : 6 0 - 6 4 9 IPNA 1992
Original article Atrial natriuretic peptide and cyclic 3'5'-guanosine monophosphate as indicators of fluid volume overload in children with chronic renal failure B. Lettgen, M. Bald, H. ValleY, K. E. Bonzel, and W. Rascher Department of Paediatric Nephrology, Universit~tsklinik ftir Kinder- und Jugendmedizin (GHS), Hufelandstrasse 55, W-4300 Essen, Federal Republic of Germany Received October 9, 1990; received in revised form July 18, 1991; accepted July 19, 1991
Abstract. Plasma atrial natriuretic peptide (ANP) and cyclic 3'5'-guanosine monophosphate (cGMP) were investigated as indicators of fluid volume overload in children and adolescents with chronic renal failure. Plasma ANP and cGMP were measured in both paediatric patients with chronic renal failure (n = 17, mean serum creatinine 371 + 2 4 2 gmol/1) and those with end-stage renal disease on haemodialysis (n = 18). cGMP was higher in children with chronic renal failure than in 45 healthy controls (1.0+0.4 vs 2.1+0.8 nmol/1, P
Pediatr Nephrol (1992) 6 : 6 0 - 6 4 9 IPNA 1992
Original article Atrial natriuretic peptide and cyclic 3'5'-guanosine monophosphate as indicators of fluid volume overload in children with chronic renal failure B. Lettgen, M. Bald, H. ValleY, K. E. Bonzel, and W. Rascher Department of Paediatric Nephrology, Universit~tsklinik ftir Kinder- und Jugendmedizin (GHS), Hufelandstrasse 55, W-4300 Essen, Federal Republic of Germany Received October 9, 1990; received in revised form July 18, 1991; accepted July 19, 1991
Abstract. Plasma atrial natriuretic peptide (ANP) and cyclic 3'5'-guanosine monophosphate (cGMP) were investigated as indicators of fluid volume overload in children and adolescents with chronic renal failure. Plasma ANP and cGMP were measured in both paediatric patients with chronic renal failure (n = 17, mean serum creatinine 371 + 2 4 2 gmol/1) and those with end-stage renal disease on haemodialysis (n = 18). cGMP was higher in children with chronic renal failure than in 45 healthy controls (1.0+0.4 vs 2.1+0.8 nmol/1, P
