Author's Accepted Manuscript
Attempted suicide in people with cooccurring bipolar and substance use disorders: Systematic review and meta-analysis Giuseppe Carrà, Francesco Bartoli, Cristina Crocamo, Kathleen T. Brady, Massimo Clerici
www.elsevier.com/locate/jad
PII: DOI: Reference:
S0165-0327(14)00361-9 http://dx.doi.org/10.1016/j.jad.2014.05.066 JAD6811
To appear in:
Journal of Affective Disorders
Received date: 28 March 2014 Revised date: 29 May 2014 Accepted date: 30 May 2014 Cite this article as: Giuseppe Carrà, Francesco Bartoli, Cristina Crocamo, Kathleen T. Brady, Massimo Clerici, Attempted suicide in people with cooccurring bipolar and substance use disorders: Systematic review and metaanalysis, Journal of Affective Disorders, http://dx.doi.org/10.1016/j.jad.2014.05.066 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
1
Attempted suicide in people with co-occurring bipolar and substance use disorders: Systematic review and meta-analysis
Giuseppe Carrà, PhD; Francesco Bartoli, PhD; Cristina Crocamo, MSc; Kathleen T. Brady, PhD; Massimo Clerici, PhD.
Author Affiliations: Division of Psychiatry, University College London, London, UK (Carrà); Department of Surgery and Interdisciplinary Medicine, University of Milano Bicocca, Monza (MB), Italy (Bartoli, Crocamo, Clerici); Department of Psychiatry and Behavioral Sciences. Medical University of South Carolina, Charleston, SC, USA (Brady).
Corresponding Author: Francesco Bartoli, PhD, University of Milano-Bicocca, Department of Surgery and Interdisciplinary Medicine, Via Cadore 48, Monza (MB), 20900 Italy. E-mail: [email protected] Phone number: 039-2333982 Fax number: 039-2332277
ABSTRACT Background: Both individuals with bipolar (BD) and those with alcohol (AUD) and other substance (SUD) use disorders are likely to attempt suicide. Comorbidity of BD and AUD/SUD may increase the likelihood of suicide attempts. We conducted a meta-analysis to estimate the association of comorbid AUD/SUD and suicide attempts in subjects with BD in the literature to date. Methods: Electronic databases through January 2013 were searched. Studies reporting rates of suicide attempts in people with co-occurring BD and AUD/SUD were retrieved. Comorbid AUD and SUD and suicide attempts rates as well as demographic, clinical, and methodological variables were extracted from each publication or obtained directly from its authors. Results: Twenty-nine of 222 studies assessed for eligibility met the inclusion criteria, comprising a total of 31,294 individuals with BD, of whom 6,308 (20.1%) had documented suicide attempts.
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There were consistent findings across the studies included. As compared to controls, subjects with BD and comorbid AUD/SUD were more likely to attempt suicide. The cross-sectional association estimates showed random-effects pooled crude ORs of 1.96 (95%CI=1.56-2.47; p
Attempted suicide in people with cooccurring bipolar and substance use disorders: Systematic review and meta-analysis Giuseppe Carrà, Francesco Bartoli, Cristina Crocamo, Kathleen T. Brady, Massimo Clerici
www.elsevier.com/locate/jad
PII: DOI: Reference:
S0165-0327(14)00361-9 http://dx.doi.org/10.1016/j.jad.2014.05.066 JAD6811
To appear in:
Journal of Affective Disorders
Received date: 28 March 2014 Revised date: 29 May 2014 Accepted date: 30 May 2014 Cite this article as: Giuseppe Carrà, Francesco Bartoli, Cristina Crocamo, Kathleen T. Brady, Massimo Clerici, Attempted suicide in people with cooccurring bipolar and substance use disorders: Systematic review and metaanalysis, Journal of Affective Disorders, http://dx.doi.org/10.1016/j.jad.2014.05.066 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
1
Attempted suicide in people with co-occurring bipolar and substance use disorders: Systematic review and meta-analysis
Giuseppe Carrà, PhD; Francesco Bartoli, PhD; Cristina Crocamo, MSc; Kathleen T. Brady, PhD; Massimo Clerici, PhD.
Author Affiliations: Division of Psychiatry, University College London, London, UK (Carrà); Department of Surgery and Interdisciplinary Medicine, University of Milano Bicocca, Monza (MB), Italy (Bartoli, Crocamo, Clerici); Department of Psychiatry and Behavioral Sciences. Medical University of South Carolina, Charleston, SC, USA (Brady).
Corresponding Author: Francesco Bartoli, PhD, University of Milano-Bicocca, Department of Surgery and Interdisciplinary Medicine, Via Cadore 48, Monza (MB), 20900 Italy. E-mail: [email protected] Phone number: 039-2333982 Fax number: 039-2332277
ABSTRACT Background: Both individuals with bipolar (BD) and those with alcohol (AUD) and other substance (SUD) use disorders are likely to attempt suicide. Comorbidity of BD and AUD/SUD may increase the likelihood of suicide attempts. We conducted a meta-analysis to estimate the association of comorbid AUD/SUD and suicide attempts in subjects with BD in the literature to date. Methods: Electronic databases through January 2013 were searched. Studies reporting rates of suicide attempts in people with co-occurring BD and AUD/SUD were retrieved. Comorbid AUD and SUD and suicide attempts rates as well as demographic, clinical, and methodological variables were extracted from each publication or obtained directly from its authors. Results: Twenty-nine of 222 studies assessed for eligibility met the inclusion criteria, comprising a total of 31,294 individuals with BD, of whom 6,308 (20.1%) had documented suicide attempts.
2
There were consistent findings across the studies included. As compared to controls, subjects with BD and comorbid AUD/SUD were more likely to attempt suicide. The cross-sectional association estimates showed random-effects pooled crude ORs of 1.96 (95%CI=1.56-2.47; p
