Europe PMC Funders Group Author Manuscript Diabetes Metab Res Rev. Author manuscript; available in PMC 2017 April 24. Published in final edited form as: Diabetes Metab Res Rev. 2017 January ; 33(1): . doi:10.1002/dmrr.2828.

Europe PMC Funders Author Manuscripts

Effects of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes Julia Otten#1, Andreas Stomby#1, Maria Waling2, Andreas Isaksson3, Anna Tellström1, Lillemor Lundin-Olsson4, Søren Brage5, Mats Ryberg1, Michael Svensson3, and Tommy Olsson1 1Department

of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden

2Department

of Food and Nutrition, Umeå University, Umeå, Sweden

3Department

of Community Medicine and Rehabilitation, Sports Medicine Unit, Umeå University, Umeå, Sweden 4Department

of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå,

Sweden 5MRC

#

Epidemiology Unit, University of Cambridge, Cambridge, UK

These authors contributed equally to this work.

Abstract Europe PMC Funders Author Manuscripts

Background—Means to reduce future risk for cardiovascular disease in subjects with type 2 diabetes are urgently needed. Methods—Thirty-two patients with type 2 diabetes (age 59±8 years) followed a Paleolithic diet for 12 weeks. Participants were randomized to either standard care exercise recommendations (PD) or 1-h supervised exercise sessions (aerobic exercise and resistance training) three times per week (PD-EX). Results—For the within group analyses, fat mass decreased by 5.7 kg (IQR: −6.6, −4.1; p