HHS Public Access Author manuscript Author Manuscript
Am Surg. Author manuscript; available in PMC 2015 June 23. Published in final edited form as: Am Surg. 2015 May ; 81(5): 192–194.
Bilateral Synchronous Benign Phyllodes Tumors Melissa Anne Mallory, MD1, Sona A. Chikarmane, MD2, Sughra Raza, MD2, Susan Lester, MD, PHD3, Stephanie A. Caterson, MD4, and Mehra Golshan, MD1
Author Manuscript
1Brigham
and Women’s Hospital, Department of Surgery, Boston, Massachusetts 02115, USA
2Brigham
and Women’s Hospital, Department of Radiology, Boston, Massachusetts 02115, USA
3Brigham
and Women’s Hospital, Department of Pathology, Boston, Massachusetts 02115, USA
4Brigham
and Women’s Hospital, Department of Plastic Surgery, Boston, Massachusetts 02115,
USA Phyllodes tumors (PTs) are rare breast neoplasms that comprise < 1% of all surgical breast tumors. They are a type of fibroepithelial lesion and exist along a clinical spectrum of disease alongside more common disease entities including fibroadenomas. PTs are similar to fibroadenomas from a clinical, radiographic, and histologic standpoint, making diagnosis challenging. The distinction has important implications, however, as PTs have a higher risk of recurrence and occasionally metastasis. Whereas bilateral and multifocal presentations are not infrequent with fibroadenomas, they are very uncommon with PTs, and most often are asynchronous and malignant.1–2 An unusual case of PT is discussed here.
Author Manuscript
A 26-year-old female presented for evaluation of bilateral breast masses. She previously had masses excised from both breasts at age 18, however pathology reports were not available. Bilateral breast masses reappeared at age 19 per the patient, and she reported recent expansion in their size and number. The patient was otherwise healthy and nulliparous. She denied any family history of breast cancer.
Author Manuscript
Physical examination revealed multiple mobile, well-circumscribed, non-tender palpable lumps in both breasts. Ultrasound demonstrated 10 right sided lesions and 5 left sided lesions, the largest measuring 5.3cm (Figure 1, a–b). One lesion from each breast (measuring 2.3cm on the right and 2.9cm on the left) was selected for surgical excisional biopsy. Microscopic examination revealed low grade/benign phyllodes tumors bilaterally, with 2 mitoses per high powered field on the right and
Am Surg. Author manuscript; available in PMC 2015 June 23. Published in final edited form as: Am Surg. 2015 May ; 81(5): 192–194.
Bilateral Synchronous Benign Phyllodes Tumors Melissa Anne Mallory, MD1, Sona A. Chikarmane, MD2, Sughra Raza, MD2, Susan Lester, MD, PHD3, Stephanie A. Caterson, MD4, and Mehra Golshan, MD1
Author Manuscript
1Brigham
and Women’s Hospital, Department of Surgery, Boston, Massachusetts 02115, USA
2Brigham
and Women’s Hospital, Department of Radiology, Boston, Massachusetts 02115, USA
3Brigham
and Women’s Hospital, Department of Pathology, Boston, Massachusetts 02115, USA
4Brigham
and Women’s Hospital, Department of Plastic Surgery, Boston, Massachusetts 02115,
USA Phyllodes tumors (PTs) are rare breast neoplasms that comprise < 1% of all surgical breast tumors. They are a type of fibroepithelial lesion and exist along a clinical spectrum of disease alongside more common disease entities including fibroadenomas. PTs are similar to fibroadenomas from a clinical, radiographic, and histologic standpoint, making diagnosis challenging. The distinction has important implications, however, as PTs have a higher risk of recurrence and occasionally metastasis. Whereas bilateral and multifocal presentations are not infrequent with fibroadenomas, they are very uncommon with PTs, and most often are asynchronous and malignant.1–2 An unusual case of PT is discussed here.
Author Manuscript
A 26-year-old female presented for evaluation of bilateral breast masses. She previously had masses excised from both breasts at age 18, however pathology reports were not available. Bilateral breast masses reappeared at age 19 per the patient, and she reported recent expansion in their size and number. The patient was otherwise healthy and nulliparous. She denied any family history of breast cancer.
Author Manuscript
Physical examination revealed multiple mobile, well-circumscribed, non-tender palpable lumps in both breasts. Ultrasound demonstrated 10 right sided lesions and 5 left sided lesions, the largest measuring 5.3cm (Figure 1, a–b). One lesion from each breast (measuring 2.3cm on the right and 2.9cm on the left) was selected for surgical excisional biopsy. Microscopic examination revealed low grade/benign phyllodes tumors bilaterally, with 2 mitoses per high powered field on the right and
