British Journal of Obstetrics and Gynaecology July 1992, Vol. 99, pp. 563-565
FETAL A N D N E O N A T A L MEDICINE
Biochemical composition of amniotic fluid and extraembryonic coelomic fluid in the first trimester of pregnancy JAMES CAMPBELL Lecturer N E V I L L E WATHEN Senior Lecturer MARY M A C I N T O S H Research Fellow PETER CASS Lecturer TIM CHARD Professor Combined Departments of Obstetrics, Gynaecology and Reproductive Physiology St Bartholomew’s Hospital and the Homerton Hospital London, UK RICHARD MAINWARINGBURTON Biochemist
ABSTRACT Objective To determine the biochemical composition of amniotic fluid and extraembryonic coelomic fluid between 8 and 12 weeks gestation. Design Prospective observational study. Subjects 40 women with a normal pregnancy between 7 and 12 weeks gestation having termination of pregnancy.
Interventions Before termination the women had a transvaginal ultrasound guided amniocentesis. Pure samples of amniotic fluid and extraembryonic coelomic fluid were obtained from each woman and standard biochemical variables were measured in each fluid sample immediately after collection. Results Levels of sodium, potassium and bicarbonate were significantly higher in amniotic fluid whilst chloride, urea, bilirubin, protein, albumin, glucose, creatinine, calcium and phosphate were present in higher concentrations in extraembryonic coelomic fluid. All differences in concentration were significant ( P
FETAL A N D N E O N A T A L MEDICINE
Biochemical composition of amniotic fluid and extraembryonic coelomic fluid in the first trimester of pregnancy JAMES CAMPBELL Lecturer N E V I L L E WATHEN Senior Lecturer MARY M A C I N T O S H Research Fellow PETER CASS Lecturer TIM CHARD Professor Combined Departments of Obstetrics, Gynaecology and Reproductive Physiology St Bartholomew’s Hospital and the Homerton Hospital London, UK RICHARD MAINWARINGBURTON Biochemist
ABSTRACT Objective To determine the biochemical composition of amniotic fluid and extraembryonic coelomic fluid between 8 and 12 weeks gestation. Design Prospective observational study. Subjects 40 women with a normal pregnancy between 7 and 12 weeks gestation having termination of pregnancy.
Interventions Before termination the women had a transvaginal ultrasound guided amniocentesis. Pure samples of amniotic fluid and extraembryonic coelomic fluid were obtained from each woman and standard biochemical variables were measured in each fluid sample immediately after collection. Results Levels of sodium, potassium and bicarbonate were significantly higher in amniotic fluid whilst chloride, urea, bilirubin, protein, albumin, glucose, creatinine, calcium and phosphate were present in higher concentrations in extraembryonic coelomic fluid. All differences in concentration were significant ( P
