Ideas and Innovations Biplanar Oncoplastic Surgery: A Novel Approach to Breast Conservation for Small and Medium Sized Breasts Maurice Y. Nahabedian, M.D. Ketan M. Patel, M.D. Alexander J. Kaminsky, M.D., M.P.H. Costanza Cocilovo, M.D. Reza Miraliakbari, M.D. Washington, D.C.; and Falls Church, Va.

Summary: Biplanar oncoplastic surgery represents a novel technique with which to address partial breast reconstruction defects in small to medium sized breasts. Traditional oncoplastic volume displacement techniques may correct contour irregularities but do not address volumetric asymmetries. Volume replacement techniques classically rely on autologous tissue flaps. A biplanar approach, with a combination of glandular rearrangement techniques and volume enhancement with submuscular implants, can result in an alternative approach in select patients to achieve symmetry.  (Plast. Reconstr. Surg. 132: 1081, 2013.) CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V.

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ncoplastic breast surgery was developed to prevent contour irregularities following breast conservation therapy.1–3 In smaller breasted patients, volume replacement techniques are usually necessary but require the use of regional flaps. Many women considering breast conservation therapy are reluctant to use these flaps because of the additional morbidity and complexity of the operations. Volume displacement techniques alone are less effective because they fail to address the volume loss in women with smaller breasts. The use of prosthetic devices for volume replacement has been largely abandoned based on historical studies citing high complication rates following radiation therapy. An early study using immediate subcutaneous implant placement demonstrated a high incidence of capsular contracture and other complications.4 More recent studies following breast conservation therapy incorporating intraoperative radiotherapy have demonstrated success in the setting of prosthetic devices.5 With increasing experience with tissue rearrangement techniques and implant reconstruction coupled with our enhanced understanding of the effects of radiation, the possibility of more reliable results From the Department of Plastic Surgery, Georgetown University Hospital; and Inova Fairfax Hospital. Received for publication April 6, 2013; accepted April 30, 2013. Copyright © 2013 by the American Society of Plastic Surgeons DOI: 10.1097/PRS.0b013e3182a3bf47

in women with smaller breasts considering breast conservation therapy has emerged.6,7 Currently, we present a technique with which to address breast conservation defects in smaller breasted patients. The technique combines both the volume displacement and volume replacement strategies using a biplanar approach. Glandular tissue rearrangement is performed and combined with a prosthetic device in a submuscular pocket. This technique results in the immediate correction of contour and volume before radiotherapy.

SURGICAL TECHNIQUE Consideration for a biplanar reconstruction is dependent on factors that include preoperative evaluation, breast size, tumor location, and tumor size. The typical patient has a body mass

Disclosure: Dr. Nahabedian is a member of the speaker’s bureau for LifeCell Corp. (Branchburg, N.J.). The other authors have no conflicts of interest or financial disclosures. No funding was used for the preparation of this article. A Video Discussion by John Y. S. Kim, M.D., accompanies this article. Go to PRSJournal.com and click on "Video Discussions" in the “Videos” tab to watch.

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Plastic and Reconstructive Surgery • November 2013 index less than 25 and a breast cup size of A or B. The tumor is usually less than 2.5 cm and located at least 2.5 cm from the nipple-areola complex. Peripheral tumor locations will tend to allow for more accurate parenchymal rearrangement without sacrificing vascular supply. In particular, lower quadrant/outer quadrant tumors may be more easily amenable to this technique. The biplanar technique differs from traditional oncoplastic techniques in that it combines the concepts of volume displacement and replacement. Candidates for biplanar oncoplastic reconstruction have a breast volume that is significantly less than what is typically seen for tissue rearrangement procedures; thus, a small device is placed to replace the volume. The device can be either a tissue expander or a permanent implant. The decision is based on patient expectations and whether it is desired to maintain or increase their preoperative breast volume. The incisional pattern for the biplanar approach is circumvertical. The preoperative and postoperative position of the nipple-areola complex will depend on the degree of ptosis. The operation is initiated by either the ablative or reconstructive surgeon and follows the preoperative markings. Skin flaps are elevated within the planes of the investing fascia of the breast to expose the location of the tumor. Typical resection volumes range from 50 to 100 g. The tissue rearrangement portion is performed first. Additional undermining of the skin flaps may be necessary to facilitate glandular rearrangement. In addition, parenchymal undermining near the defect is also necessary to facilitate glandular rearrangement. The specific rearrangement techniques will depend on the location of the glandular defect. With all rearrangement techniques, it is important to be cognizant of the blood supply to the parenchyma to minimize the incidence of skin/fat necrosis. The prosthetic device is inserted in the subpectoral plane, thus defining the biplanar technique. The subpectoral plane is entered at the inferior edge of the pectoralis major muscle in the standard fashion. Because these breasts are typically small with low resection volumes, the smallest devices are typically used. Permanent devices are usually 100- to 125-cc smooth or textured round implants with a low to moderate profile. Tissue expanders are usually 250 cc, medium height, and only partially filled in the operating room.

CASE REPORT A 40-year-old woman with a small right upper quadrant tumor and B cup breasts was scheduled for immediate biplanar

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Fig. 1. Preprocedure photograph obtained following wire placement before partial mastectomy.

Fig. 2. Intraoperative image demonstrating the submuscular plane with an implant in place. A smooth moderate plus profile implant was placed (250 cc). oncoplastic surgery. The wire localization and preoperative markings are shown in Figure 1. Similar to the above-described technique, glandular rearrangement occurred following confirmation of negative surgical margins. Following tumorectomy and rearrangement, the subpectoral pocket was created. A moderate profile implant (125 cc) was inserted (Fig. 2). A contralateral augmentation for symmetry was performed before radiation therapy. A postoperative photograph obtained 5 months after radiation therapy is shown (Fig. 3). The patient’s irradiated breast remains soft and the patient remains satisfied with her reconstruction.

DISCUSSION As oncoplastic breast surgery continues to gain acceptance, novel approaches continue to evolve.8–10 Current options are based on volume displacement techniques and volume replacement techniques that have traditionally included

Volume 132, Number 5 • Biplanar Oncoplastic Surgery

Fig. 3. Six-month postoperative image (5 months after radiation therapy). A contralateral augmentation is noted. A smooth moderate profile implant was placed on the contralateral side (150 cc).

autologous tissues. The use of prosthetic devices as a volume replacement tool in the setting of breast conservation has been historically resisted because of the untoward effects following radiation therapy. Early studies evaluating the role of prosthetic devices following breast conservation demonstrated a higher complication rate because the devices were typically placed above the pectoralis major muscle. An early study by Thomas et al. found that subcutaneous implant placement following wide local excision resulted in suboptimal outcomes. They evaluated 59 patients that underwent this immediate reconstructive technique and found that 19 percent of implants needed removal and that approximately half of the patients reported their outcomes as acceptable.4 There is an increasing body of evidence in the arena of breast reconstruction demonstrating that prosthetic devices can sometimes be effectively used in the setting of total mastectomy and irradiation. Spear et al. found that, of patients who received radiation therapy following expander placement after mastectomy, 60 percent had occurrence of grade III/IV capsular contracture. Despite over half of patients having capsular contracture, 70 percent required only capsular modification, with preservation of the implant reconstruction during 15 months’ follow-up.7 This progressive shift has been mirrored by advances in skin-sparing techniques, improved implant technology, and increasing use of acellular dermal matrices in breast reconstruction. These observations have led to our application of these concepts in the setting of oncoplastic surgery. The concept of biplanar oncoplastic surgery addresses two reconstructive challenges. First,

glandular tissue rearrangement techniques allow for restoration of natural breast contour. Excessive tissue mobilization must be avoided to prevent wound healing complications. Second, subpectoral implant or expander placement allows for restoration of volume to the reconstructed breast to prevent volume discrepancies. Volume restoration is crucial in smaller breasts because of the relatively large percentage of the breast that has been excised.11 Placement of a tissue expander allows the option for a two-staged reconstruction, which is preferable for patients who have not committed to a particular implant size or who desire an increase in preoperative volume. Because the devices used are placed in the subpectoral position and relatively small (100 to 250 cc), there have been no reported concerns from the radiation oncologists regarding dosimetry or targeting. Future advancements in targeted breast irradiation and intraoperative radiotherapy may obviate many of the whole breast irradiation-induced effects commonly credited for the late development of detrimental sequelae. Rietjens et al. introduced the concept of immediate augmentation mammaplasty following breast conservation and intraoperative radiotherapy.12 Their cumulative experience of 29 patients found sustained long-term results, with low capsular contracture rates despite radiotherapy.5

CONCLUSIONS The biplanar oncoplastic technique provides another option for women with smaller breasts that are not interested in partial breast reconstruction using autologous tissue and/or total mastectomy. Potential increased morbidity may be associated with this technique, as contralateral symmetry procedures add costs and more operative time. Although our experience is limited at this time, our early results are encouraging and we are offering this option to appropriate candidates that meet our patient selection criteria. Maurice Y. Nahabedian, M.D. Department of Plastic Surgery Georgetown University 3800 Reservoir Road NW Washington, D.C. 20007 [email protected]

REFERENCES 1. Berry MG, Fitoussi AD, Curnier A, Couturaud B, Salmon RJ. Oncoplastic breast surgery: A review and systematic approach. J Plast Reconstr Aesthet Surg. 2010;63:1233–1243. 2. Hill-Kayser CE, Vachani C, Hampshire MK, Di Lullo GA, Metz JM. Cosmetic outcomes and complications reported by

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Plastic and Reconstructive Surgery • November 2013 patients having undergone breast-conserving treatment. Int J Radiat Oncol Biol Phys. 2012;83:839–844. 3. Krishnan L, Stanton AL, Collins CA, Liston VE, Jewell WR. Form or function? Part 2. Objective cosmetic and functional correlates of quality of life in women treated with breastconserving surgical procedures and radiotherapy. Cancer 2001;91:2282–2287. 4. Thomas PR, Ford HT, Gazet JC. Use of silicone implants after wide local excision of the breast. Br J Surg. 1993;80:868–870. 5. De Lorenzi F, Lohsiriwat V, Barbieri B, et al. Immediate breast reconstruction with prostheses after conservative treatment plus intraoperative radiotherapy: Long term esthetic and oncological outcomes. Breast 2012;21:374–379. 6. Breuing KH, Colwell AS. Immediate breast tissue expanderimplant reconstruction with inferolateral AlloDerm hammock and postoperative radiation: A preliminary report Eplasty 2009;9:e16. 7. Spear SL, Seruya M, Rao SS, et al. Two-stage prosthetic breast reconstruction using AlloDerm including outcomes of different timings of radiotherapy. Plast Reconstr Surg. 2012;130:1–9.

8. Clough KB, Thomas SS, Fitoussi AD, Couturaud B, Reyal F, Falcou MC. Reconstruction after conservative treatment for breast cancer: Cosmetic sequelae classification revisited. Plast Reconstr Surg. 2004;114:1743–1753. 9. Fitoussi AD, Berry MG, Couturaud B, Falcou MC, Salmon RJ. Management of the post-breast-conserving therapy defect: Extended follow-up and reclassification. Plast Reconstr Surg. 2010;125:783–791. 10. Kronowitz SJ, Kuerer HM, Buchholz TA, Valero V, Hunt KK. A management algorithm and practical oncoplastic surgical techniques for repairing partial mastectomy defects. Plast Reconstr Surg. 2008;122:1631–1647. 11. Cochrane RA, Valasiadou P, Wilson AR, Al-Ghazal SK, Macmillan RD. Cosmesis and satisfaction after breast-conserving surgery correlates with the percentage of breast volume excised. Br J Surg. 2003;90:1505–1509. 12. Rietjens M, De Lorenzi F, Veronesi P, et al. Breast conservative treatment in association with implant augmentation and intraoperative radiotherapy. J Plast Reconstr Aesthet Surg. 2006;59:532–535.

Evidence-Based Medicine: Questions and Answers Q: Will PRS still review, accept, and publish papers with lower levels of evidence? A: Yes, PRS welcomes manuscripts of all Level of Evidence grades and manuscripts that are not amenable to LOE grading. The LOE grade should be seen dispassionately as a number, a quantitative indicator of the level of evidence in an article. Papers with lower LOE grades (IV and V) are not “worse” than papers with higher LOE grades (I–III); they simply have data of a different level. It makes sense that randomized, controlled, blinded, multicenter trials with hundreds or thousands of patients and years of follow-up would have a higher level of evidence than a single author’s experience in a clinical series. However, given the demands of such studies, it also makes sense that there would be few randomized controlled trials but many single-author series or expert opinions. Such series and expert opinions do have value. PRS welcomes the submission of such papers and will continue to publish them.

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Biplanar oncoplastic surgery: a novel approach to breast conservation for small and medium sized breasts.

Biplanar oncoplastic surgery represents a novel technique with which to address partial breast reconstruction defects in small to medium sized breasts...
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