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Journal of Diabetes 6 (2014) 574–576
RESEARCH LETTER
Blood glucose is associated with chronic kidney disease in subjects with impaired glucose tolerance, but not in those with impaired fasting glucose Chuan WANG,* Jun SONG,* Yu SUN, Xinguo HOU and Li CHEN Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, China
Keywords: blood glucose, chronic kidney disease, estimated glomerular filtration rate, impaired fasting glucose, impaired glucose tolerance.
Chronic kidney disease (CKD), characterized by albuminuria or reduced kidney function, is a worldwide public health problem.1 Diabetes is one of the leading causes of CKD and glycemic control offers significant benefits in the prevention of CKD. However, the relationship between blood glucose (including fasting blood glucose [FBG], postprandial blood glucose [PBG], and HbA1c) and CKD remains uncertain in subjects with isolated impaired fasting glucose (IFG) and those with isolated impaired glucose tolerance (IGT). Based on data derived from a cross-sectional study, which was part of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study,2 the present paper reports, for the first time, on the association between blood glucose and changes in estimated glomerular filtration rate (eGFR) and the risk of CKD in IFG and IGT in middle-aged and older Chinese individuals. A random sample of 10 028 subjects aged ≥40 years old was recruited from four urban communities in Jinan and Jining City of Shandong Province from January to April 2012. Demographic characteristics were obtained by trained investigators through a standard questionnaire. Height, weight and blood pressure (BP) were also measured. After an overnight fast, venous blood samples were collected for measurement of FBG, HbA1c, insulin,
Correspondence Li Chen and Xinguo Hou, Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan 250012, Shandong, China. Tel.: +86 13791122906 Fax: +86 53182169323 Email: [email protected] *These authors contributed equally to this work. Received: 21 May 2014; accepted 27 May 2014. doi: 10.1111/1753-0407.12174
574
lipid profiles and creatinine. The PBG was determined after subjects had completed a 75-g oral glucose tolerance test (OGTT). Eventually, 695 subjects with IFG (FBG 6.1–7.0 mmol/L and PBG
Journal of Diabetes 6 (2014) 574–576
RESEARCH LETTER
Blood glucose is associated with chronic kidney disease in subjects with impaired glucose tolerance, but not in those with impaired fasting glucose Chuan WANG,* Jun SONG,* Yu SUN, Xinguo HOU and Li CHEN Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, China
Keywords: blood glucose, chronic kidney disease, estimated glomerular filtration rate, impaired fasting glucose, impaired glucose tolerance.
Chronic kidney disease (CKD), characterized by albuminuria or reduced kidney function, is a worldwide public health problem.1 Diabetes is one of the leading causes of CKD and glycemic control offers significant benefits in the prevention of CKD. However, the relationship between blood glucose (including fasting blood glucose [FBG], postprandial blood glucose [PBG], and HbA1c) and CKD remains uncertain in subjects with isolated impaired fasting glucose (IFG) and those with isolated impaired glucose tolerance (IGT). Based on data derived from a cross-sectional study, which was part of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study,2 the present paper reports, for the first time, on the association between blood glucose and changes in estimated glomerular filtration rate (eGFR) and the risk of CKD in IFG and IGT in middle-aged and older Chinese individuals. A random sample of 10 028 subjects aged ≥40 years old was recruited from four urban communities in Jinan and Jining City of Shandong Province from January to April 2012. Demographic characteristics were obtained by trained investigators through a standard questionnaire. Height, weight and blood pressure (BP) were also measured. After an overnight fast, venous blood samples were collected for measurement of FBG, HbA1c, insulin,
Correspondence Li Chen and Xinguo Hou, Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan 250012, Shandong, China. Tel.: +86 13791122906 Fax: +86 53182169323 Email: [email protected] *These authors contributed equally to this work. Received: 21 May 2014; accepted 27 May 2014. doi: 10.1111/1753-0407.12174
574
lipid profiles and creatinine. The PBG was determined after subjects had completed a 75-g oral glucose tolerance test (OGTT). Eventually, 695 subjects with IFG (FBG 6.1–7.0 mmol/L and PBG
