Contents
F o re w o rd ........................................................................................................ 125 Acknowledgements ...................................................................................... 126
Original Papers Woolf, N.: Interaction between Mural Thrombi and the Underlying Artery Wall ................................................................................................................127 Busch, C.; Ljungman, C.; Heldin, C.-M.; Waskson, E., and Öbrink, B.: Surface Properties of Cultured Endothelial C ells........................................ 142 Clopath, P.; Müller, K.; Stäubli, W., and Bürk, R R.: In vivo and in vitro Studies on Endothelial Regeneration .......................................................... 149 Barnes, M.J. and MacIntyre, D.E.: Platelet-Reactivity of Isolated Consti tuents of the Blood Vessel Wall .................................................................. 158 Vargaftig, B.B.; Lefort, J.; Prancan, A.V.; Chignard, M., and Benveniste, J.: Platelet-Lung in vivo Interactions: an Artifact of a Multi-Purpose M odel?............................................................................................................. 171 Cazenave, J.-P.; Dejana, E.; Kinlough-Rathbone, R.; Packham, M.A., and Fraser Mustard, J.: Platelet Interactions with the Endothelium and the Subendothelium: the Role of Thrombin and Prostacyclin .......................183 Nord^y, A.: Albumin-Bound Fatty Acids, Platelets and Endothelial Cells in Thrombogenesis ............................................................................................193 Evensen, S.A.: Injury to Cultured Endothelial Cells: the Role of Lipo proteins and Thrombo-Active Agents ........................................................203 Hornstra, G. and Hemker, H.C.: Clot-Promoting Effect of Platelet-Vessel Wall Interaction: Influence of Dietary Fats and Relation to Arterial Thrombus Formation in R a t s ....................................................................... 211
Contents
124
Dyerberg, J. and Bang, H.O.: Lipid Metabolism, Atherogenesis, and Haemo stasis in Eskimos: the Role of the Prostaglandin-3 Family .................... 227 Renaud, S.; Morazain, R.; McGregor, L., and Baudier, F.: Dietary Fats and Platelet Functions in Relation to Atherosclerosis and Coronary Heart Disease .......................................................................................................... 234 Moncada, S. and Amezcua, J.L.: Prostacyclin, Thromboxane A2 Inter actions in Haemostasis and Thrombosis .....................................................252 Willems, Ch. and Aken, W.G. van: Production of Prostacyclin by Vascular Endothelial Cells ........................................................................................... 266 MacIntyre, D.E.: Modulation of Platelet Function by Prostaglandins: Characterization of Platelet Receptors for Stimulatory Prostaglandins and the Role of Arachidonate Metabolites in Platelet Degranulation Responses ..................................................................................................... 274 Gryglewski, R.J.; Korbut, R., and Splawinski, J.: Endogenous Mechanisms which Regulate Prostacyclin Release ....................................................... 294 Gaetano, G. de; Remuzzi, G.; Mysliwiec, M., and Donati, M.B.: Vascular Prostacyclin and Plasminogen Activator Activity in Experimental and Clinical Conditions of Disturbed Haemostasis or Thrombosis ................. 300 Bolhuis, P.A.; Sakariassen, K.S., and Sixma, J.J.: Adhesion of Blood Plate lets to Human Arterial Subendothelium: Role of Factor VUI-Von Willebrand Factor ........................................................................................ 312 0sterud, B.: The Role of Endothelial Cells and Subendothelial Components in the Initiation of Blood Coagulation ....................................................... 324 Emeis, J.J.: The Vascular Wall and Fibrinolysis ................................................332 Baumgartner, H.R.: Effects of Acetylsalicyclic Acid, Sulfinpyrazone and Dipyridamole on Platelet Adhesion and Aggregation in Flowing Native and Anticoagulated B lo o d ............................................................................340 Butler, K.D.; Wallis, R.B., and White, A.M.: A Study of the Relationship between ex vivo and in vivo Effects of Sulphinpyrazone in the Guinea P ig .................................................................................................................... 352
F o re w o rd ........................................................................................................ 125 Acknowledgements ...................................................................................... 126
Original Papers Woolf, N.: Interaction between Mural Thrombi and the Underlying Artery Wall ................................................................................................................127 Busch, C.; Ljungman, C.; Heldin, C.-M.; Waskson, E., and Öbrink, B.: Surface Properties of Cultured Endothelial C ells........................................ 142 Clopath, P.; Müller, K.; Stäubli, W., and Bürk, R R.: In vivo and in vitro Studies on Endothelial Regeneration .......................................................... 149 Barnes, M.J. and MacIntyre, D.E.: Platelet-Reactivity of Isolated Consti tuents of the Blood Vessel Wall .................................................................. 158 Vargaftig, B.B.; Lefort, J.; Prancan, A.V.; Chignard, M., and Benveniste, J.: Platelet-Lung in vivo Interactions: an Artifact of a Multi-Purpose M odel?............................................................................................................. 171 Cazenave, J.-P.; Dejana, E.; Kinlough-Rathbone, R.; Packham, M.A., and Fraser Mustard, J.: Platelet Interactions with the Endothelium and the Subendothelium: the Role of Thrombin and Prostacyclin .......................183 Nord^y, A.: Albumin-Bound Fatty Acids, Platelets and Endothelial Cells in Thrombogenesis ............................................................................................193 Evensen, S.A.: Injury to Cultured Endothelial Cells: the Role of Lipo proteins and Thrombo-Active Agents ........................................................203 Hornstra, G. and Hemker, H.C.: Clot-Promoting Effect of Platelet-Vessel Wall Interaction: Influence of Dietary Fats and Relation to Arterial Thrombus Formation in R a t s ....................................................................... 211
Contents
124
Dyerberg, J. and Bang, H.O.: Lipid Metabolism, Atherogenesis, and Haemo stasis in Eskimos: the Role of the Prostaglandin-3 Family .................... 227 Renaud, S.; Morazain, R.; McGregor, L., and Baudier, F.: Dietary Fats and Platelet Functions in Relation to Atherosclerosis and Coronary Heart Disease .......................................................................................................... 234 Moncada, S. and Amezcua, J.L.: Prostacyclin, Thromboxane A2 Inter actions in Haemostasis and Thrombosis .....................................................252 Willems, Ch. and Aken, W.G. van: Production of Prostacyclin by Vascular Endothelial Cells ........................................................................................... 266 MacIntyre, D.E.: Modulation of Platelet Function by Prostaglandins: Characterization of Platelet Receptors for Stimulatory Prostaglandins and the Role of Arachidonate Metabolites in Platelet Degranulation Responses ..................................................................................................... 274 Gryglewski, R.J.; Korbut, R., and Splawinski, J.: Endogenous Mechanisms which Regulate Prostacyclin Release ....................................................... 294 Gaetano, G. de; Remuzzi, G.; Mysliwiec, M., and Donati, M.B.: Vascular Prostacyclin and Plasminogen Activator Activity in Experimental and Clinical Conditions of Disturbed Haemostasis or Thrombosis ................. 300 Bolhuis, P.A.; Sakariassen, K.S., and Sixma, J.J.: Adhesion of Blood Plate lets to Human Arterial Subendothelium: Role of Factor VUI-Von Willebrand Factor ........................................................................................ 312 0sterud, B.: The Role of Endothelial Cells and Subendothelial Components in the Initiation of Blood Coagulation ....................................................... 324 Emeis, J.J.: The Vascular Wall and Fibrinolysis ................................................332 Baumgartner, H.R.: Effects of Acetylsalicyclic Acid, Sulfinpyrazone and Dipyridamole on Platelet Adhesion and Aggregation in Flowing Native and Anticoagulated B lo o d ............................................................................340 Butler, K.D.; Wallis, R.B., and White, A.M.: A Study of the Relationship between ex vivo and in vivo Effects of Sulphinpyrazone in the Guinea P ig .................................................................................................................... 352
