Body mass index and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort Aysel M¨uezzinler, Ute Mons, Aida Karina Dieffenbach, Katja Butterbach, Kai-Uwe Saum, Matthias Schick, Hermann Stammer, Petra Boukamp, Bernd Holleczek, Christa Stegmaier, Hermann Brenner PII: DOI: Reference:

S0531-5565(15)30097-8 doi: 10.1016/j.exger.2015.11.019 EXG 9746

To appear in:

Experimental Gerontology

Received date: Revised date: Accepted date:

1 September 2015 27 November 2015 28 November 2015

Please cite this article as: M¨ uezzinler, Aysel, Mons, Ute, Dieffenbach, Aida Karina, Butterbach, Katja, Saum, Kai-Uwe, Schick, Matthias, Stammer, Hermann, Boukamp, Petra, Holleczek, Bernd, Stegmaier, Christa, Brenner, Hermann, Body mass index and leukocyte telomere length dynamics among older adults: Results from the ESTHER cohort, Experimental Gerontology (2015), doi: 10.1016/j.exger.2015.11.019

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ACCEPTED MANUSCRIPT Body mass index and leukocyte telomere length dynamics among older adults: Results from the ESTHER Cohort

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Aysel Müezzinlera,b*, Ute Monsa*, Aida Karina Dieffenbacha,c, Katja Butterbacha, Kai-Uwe Sauma, Matthias Schickd, Hermann Stammere, Petra Boukampe, Bernd Holleczekf, Christa Stegmaierf, Hermann

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Brennera,b

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a. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120 Heidelberg, Germany

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b. Network Aging Research (NAR), University of Heidelberg, Heidelberg, Germany c. German Cancer Consortium (DKTK), Heidelberg, Germany

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d. Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany e. Division of Genetics of Skin Carcinogenesis, German Cancer Research Center (DKFZ), Im

Saarland Cancer Registry, Präsident-Baltz-Straße 5, 66119 Saarbrücken, Germany

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f.

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Neuenheimer Feld 280, 69120 Heidelberg, Germany

* These authors contributed equally to this work.

Disclosure: The authors declare no conflict of interest.

Author for correspondence: Dr. Ute Mons German Cancer Research Center (DKFZ) Division of Clinical Epidemiology and Aging Research Im Neuenheimer Feld 581 69120 Heidelberg, Germany Phone: +49 6221-42-1344, Fax: +49 6221-42-1302 E-mail: [email protected]

Word Count: Abstract: 245 | Main text: 3371 1

ACCEPTED MANUSCRIPT Abstract Objective: Telomere length (TL) has been proposed as a biomarker of ageing, which might be used to

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identify individuals at higher risk of age-related diseases. Obesity is a well-known risk factor for several diseases. This study aims to analyse the associations of BMI with TL and rate of TL change in older

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adults.

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Methods: Leukocyte TL (LTL) was measured by quantitative PCR in blood samples of 3600 older adults

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aged 50-75 years obtained at the baseline examination of a population-based cohort study in Germany. For longitudinal analyses, measurements were repeated in blood samples obtained at 8-year follow-up from

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1000 participants. Multivariate linear regression models were used to estimate associations of BMI with LTL and changes in LTL over time.

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Results: LTL was inversely associated with age (r=-0.090, p