Neurotherapeutics DOI 10.1007/s13311-014-0277-y
ORIGINAL ARTICLE
Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma Elisa R. Zanier & Francesca Pischiutta & Loredana Riganti & Federica Marchesi & Elena Turola & Stefano Fumagalli & Carlo Perego & Emanuela Parotto & Paola Vinci & Pietro Veglianese & Giovanna D’Amico & Claudia Verderio & Maria-Grazia De Simoni
# The American Society for Experimental NeuroTherapeutics, Inc. 2014
Abstract Microglia/macrophages (M) are major contributors to postinjury inflammation, but they may also promote brain repair in response to specific environmental signals that drive classic (M1) or alternative (M2) polarization. We investigated the activation and functional changes of M in mice with traumatic brain injuries and receiving intracerebroventricular human bone marrow mesenchymal stromal cells (MSCs) or saline infusion. MSCs upregulated Ym1 and Arginase-1 mRNA (p
ORIGINAL ARTICLE
Bone Marrow Mesenchymal Stromal Cells Drive Protective M2 Microglia Polarization After Brain Trauma Elisa R. Zanier & Francesca Pischiutta & Loredana Riganti & Federica Marchesi & Elena Turola & Stefano Fumagalli & Carlo Perego & Emanuela Parotto & Paola Vinci & Pietro Veglianese & Giovanna D’Amico & Claudia Verderio & Maria-Grazia De Simoni
# The American Society for Experimental NeuroTherapeutics, Inc. 2014
Abstract Microglia/macrophages (M) are major contributors to postinjury inflammation, but they may also promote brain repair in response to specific environmental signals that drive classic (M1) or alternative (M2) polarization. We investigated the activation and functional changes of M in mice with traumatic brain injuries and receiving intracerebroventricular human bone marrow mesenchymal stromal cells (MSCs) or saline infusion. MSCs upregulated Ym1 and Arginase-1 mRNA (p
