Osteoporos Int (2015) 26:521–529 DOI 10.1007/s00198-014-2878-z
ORIGINAL ARTICLE
Bone mineral density after childhood cancer in 346 long-term adult survivors of childhood cancer M. A. H. den Hoed & B. C. Klap & M. L. te Winkel & R. Pieters & M. van Waas & S. J. C. M. M. Neggers & A. M. Boot & K. Blijdorp & W. van Dorp & S. M. F. Pluijm & M. M. van den Heuvel-Eibrink
Received: 1 March 2014 / Accepted: 27 August 2014 / Published online: 11 September 2014 # International Osteoporosis Foundation and National Osteoporosis Foundation 2014
Abstract Summary More than 45 % of long-term childhood cancer survivors (CCS) were diagnosed with osteopenia. Our data suggest that greater awareness for osteopenia is warranted in long-term CCS, especially in survivors M.A.H. den Hoed and B.C. Klap shared first authorship and S.M.F. Pluijm and M.M. van den Heuvel-Eibrink shared last authorship. Electronic supplementary material The online version of this article (doi:10.1007/s00198-014-2878-z) contains supplementary material, which is available to authorized users. M. A. H. den Hoed : B. C. Klap : M. L. te Winkel : M. van Waas : S. J. C. M. M. Neggers : K. Blijdorp : W. van Dorp : S. M. F. Pluijm : M. M. van den Heuvel-Eibrink (*) Department of Paediatric Oncology/Haematology, Erasmus University Medical Center (Erasmus MC)-Sophia Children’s Hospital, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands e-mail: [email protected] R. Pieters Princess Maxima Center for Paediatric Oncology, Utrecht, The Netherlands S. J. C. M. M. Neggers : K. Blijdorp Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center (Erasmus MC), Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands A. M. Boot Department of Paediatric Endocrinology, University Medical Centre Groningen (UMCG), Hanzeplein 1, 9700 RB Groningen, The Netherlands W. van Dorp Department of Gynaecology, Erasmus University Medical Center (Erasmus MC), Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
who are older than 30 years, male, and underweight and were treated with cranial-spinal radiotherapy and/or steroids. Introduction Osteopenia is a potential complication of childhood cancer treatment, but the magnitude of this problem in survivors is unknown. We examined (determinants of) bone mineral density (BMD) status in long-term survivors of adult childhood cancer. Methods This retrospective single-centre cohort study included 346 subjects with the most common types of childhood cancer. Subjects had a median age at diagnosis of 7.0 years (range 0.1–16.8 years), a median age at followup of 24.5 years (range 18.0–47.6 years) and a median follow-up time of 16.7 years (range 5.6–39.9 years). Total body BMD (BMD TB ) and BMD of the lumbar spine (BMDLS) were measured by dual X-ray absorptiometry. Osteopenia was defined as BMD standardized deviation score (SDS) below −1. Results Survivors had a lower BMDTB and BMDLS (mean SDS −0.55; p
ORIGINAL ARTICLE
Bone mineral density after childhood cancer in 346 long-term adult survivors of childhood cancer M. A. H. den Hoed & B. C. Klap & M. L. te Winkel & R. Pieters & M. van Waas & S. J. C. M. M. Neggers & A. M. Boot & K. Blijdorp & W. van Dorp & S. M. F. Pluijm & M. M. van den Heuvel-Eibrink
Received: 1 March 2014 / Accepted: 27 August 2014 / Published online: 11 September 2014 # International Osteoporosis Foundation and National Osteoporosis Foundation 2014
Abstract Summary More than 45 % of long-term childhood cancer survivors (CCS) were diagnosed with osteopenia. Our data suggest that greater awareness for osteopenia is warranted in long-term CCS, especially in survivors M.A.H. den Hoed and B.C. Klap shared first authorship and S.M.F. Pluijm and M.M. van den Heuvel-Eibrink shared last authorship. Electronic supplementary material The online version of this article (doi:10.1007/s00198-014-2878-z) contains supplementary material, which is available to authorized users. M. A. H. den Hoed : B. C. Klap : M. L. te Winkel : M. van Waas : S. J. C. M. M. Neggers : K. Blijdorp : W. van Dorp : S. M. F. Pluijm : M. M. van den Heuvel-Eibrink (*) Department of Paediatric Oncology/Haematology, Erasmus University Medical Center (Erasmus MC)-Sophia Children’s Hospital, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands e-mail: [email protected] R. Pieters Princess Maxima Center for Paediatric Oncology, Utrecht, The Netherlands S. J. C. M. M. Neggers : K. Blijdorp Department of Internal Medicine, Section Endocrinology, Erasmus University Medical Center (Erasmus MC), Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands A. M. Boot Department of Paediatric Endocrinology, University Medical Centre Groningen (UMCG), Hanzeplein 1, 9700 RB Groningen, The Netherlands W. van Dorp Department of Gynaecology, Erasmus University Medical Center (Erasmus MC), Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
who are older than 30 years, male, and underweight and were treated with cranial-spinal radiotherapy and/or steroids. Introduction Osteopenia is a potential complication of childhood cancer treatment, but the magnitude of this problem in survivors is unknown. We examined (determinants of) bone mineral density (BMD) status in long-term survivors of adult childhood cancer. Methods This retrospective single-centre cohort study included 346 subjects with the most common types of childhood cancer. Subjects had a median age at diagnosis of 7.0 years (range 0.1–16.8 years), a median age at followup of 24.5 years (range 18.0–47.6 years) and a median follow-up time of 16.7 years (range 5.6–39.9 years). Total body BMD (BMD TB ) and BMD of the lumbar spine (BMDLS) were measured by dual X-ray absorptiometry. Osteopenia was defined as BMD standardized deviation score (SDS) below −1. Results Survivors had a lower BMDTB and BMDLS (mean SDS −0.55; p
