HHS Public Access Author manuscript Author Manuscript
Cancer Causes Control. Author manuscript; available in PMC 2017 January 01. Published in final edited form as: Cancer Causes Control. 2016 January ; 27(1): 39–46. doi:10.1007/s10552-015-0680-7.
Bone mineral density and mammographic density in Mexican women Heidi Moseson1,*, Megan S. Rice3,*, Ruy López-Ridaura4, Kimberly A. Bertrand2,3, Gabriela Torres4, Margarita Blanco5, Juan Alfredo Tamayo-Orozco6, Martin Lajous2,4,7, and Isabelle Romieu8 1Department
Author Manuscript
of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA
2Department
of Epidemiology, Harvard School of Public Health, Boston, MA, USA
3Channing
Division of Network Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA, USA
4Center
for Research on Population Health, National Institute of Public Health, Mexico
5Medical
Direction, Social Security and Services Institute for the Employees of the State, Mexico City, Mexico
6Mexican
Committee for the Prevention of Osteoporosis, Mexico City, Mexico
7Inserm
Author Manuscript
(Institut National de la Santé et de la Recherche Médicale), Center for Research in Epidemiology and Population Health (CESP), U1018, Villejuif, France
8International
Agency for Research on Cancer, Lyon, France
Abstract Background—Bone mineral density (BMD) is a putative marker for lifetime exposure to estrogen. Studies that have explored whether BMD is a determinant of mammographic density (MD) have observed inconsistent results. Therefore, we examined this potential association in a sample of women (N=1,516) from the clinical sub-cohort in the Mexican Teachers’ Cohort (N=115,315).
Author Manuscript
Methods—We used multivariable linear regression to assess the association between quartiles of BMD and percent MD, as well as total dense and non-dense area of the breast, stratified by menopausal status. We also examined the associations by body mass index (BMI) (
Cancer Causes Control. Author manuscript; available in PMC 2017 January 01. Published in final edited form as: Cancer Causes Control. 2016 January ; 27(1): 39–46. doi:10.1007/s10552-015-0680-7.
Bone mineral density and mammographic density in Mexican women Heidi Moseson1,*, Megan S. Rice3,*, Ruy López-Ridaura4, Kimberly A. Bertrand2,3, Gabriela Torres4, Margarita Blanco5, Juan Alfredo Tamayo-Orozco6, Martin Lajous2,4,7, and Isabelle Romieu8 1Department
Author Manuscript
of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA
2Department
of Epidemiology, Harvard School of Public Health, Boston, MA, USA
3Channing
Division of Network Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA, USA
4Center
for Research on Population Health, National Institute of Public Health, Mexico
5Medical
Direction, Social Security and Services Institute for the Employees of the State, Mexico City, Mexico
6Mexican
Committee for the Prevention of Osteoporosis, Mexico City, Mexico
7Inserm
Author Manuscript
(Institut National de la Santé et de la Recherche Médicale), Center for Research in Epidemiology and Population Health (CESP), U1018, Villejuif, France
8International
Agency for Research on Cancer, Lyon, France
Abstract Background—Bone mineral density (BMD) is a putative marker for lifetime exposure to estrogen. Studies that have explored whether BMD is a determinant of mammographic density (MD) have observed inconsistent results. Therefore, we examined this potential association in a sample of women (N=1,516) from the clinical sub-cohort in the Mexican Teachers’ Cohort (N=115,315).
Author Manuscript
Methods—We used multivariable linear regression to assess the association between quartiles of BMD and percent MD, as well as total dense and non-dense area of the breast, stratified by menopausal status. We also examined the associations by body mass index (BMI) (
